Protein Alignment sti and LAMA2

DIOPT Version :9

• Sequence 1: NP_001261768.1
• Gene: sti / 39429
• FlyBaseID: FBgn0002466
• Length: 1858
• Species: Drosophila melanogaster
• Sequence 2: XP_016866340.1
• Gene: LAMA2 / 3908
• HGNCID: 6482
• Length: 3212
• Species: Homo sapiens
• Alignment Length: 1198
• Identity: 245/1198 - (20%)
• Similarity: 414/1198 - (34%)
• Gaps: 411/1198 - (34%)

  Fly   736 ENETQEVRAECHRL------ERELQLAECRCQLAESSLATQVSPYETAPGSLTELNAIEDQLRAD 794
            ||.|||::   |.|      ||.:||||
Human  1703 ENMTQELK---HLLSPQRAPERLIQLAE------------------------------------- 1727

  Fly   795 LLAAKESENHQKGRADQLQTLVTKLEQMLERFNEQSLSPTKSHSSRKQEGETVGDMLERQNEKLE 859
                           ..|.||||::.::|.|..:.:           .:||..|...||.|.:.:
Human  1728 ---------------GNLNTLVTEMNELLTRATKVT-----------ADGEQTGQDAERTNTRAK 1766

  Fly   860 DKLAAVREQMIVERQAARTANLSLWKVEKQLEEALSEKKLLARRMELTEDRIKKVQNASDEAQRM 924
            .....::|       .||.|       |...|:|:...:.|..|.|..|..::.:|...|:..:.
Human  1767 SLGEFIKE-------LARDA-------EAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKE 1817

  Fly   925 LKTSQEETRQRESRIEELKQELAAAKRDVLKEHRQWEKAEQERMKCKSEIIEHLANVHRLEQQET 989
            |:....||::     |..:.||.||:..:.|..:.:.::..|.                 |:.|.
Human  1818 LRRKNLETQK-----EIAEDELVAAEALLKKVKKLFGESRGEN-----------------EEMEK 1860

  Fly   990 ELRQKLRQIQSRFDGVTLEQKNTIRELQEEREKSRKANDSCLVLQKELKQLTDNFQRLKYACSIT 1054
            :||:||...:::.|       :....|:|..:|.|:||....|.||.:
Human  1861 DLREKLADYKNKVD-------DAWDLLREATDKIREANRLFAVNQKNM----------------- 1901

  Fly  1055 DSQLTEVETMLKSEQERNKSQKSQLD-TLHEK---LRERNDQLTDLRKQLTTVESEKRLAEQRAQ 1115
                    |.|:.::|..:|.|.|:: ||.|.   |.|.|....::...:..||..:......::
Human  1902 --------TALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSE 1958

  Fly  1116 VLASEIDELRLNLKEQQ-KKLVAQQDQLVEQTNALFATQERAELLDG-----QNANYEAQTA--- 1171
            .|..:||:|...:|::: .:.|:|.:....|.|      :.:.:|||     :|.::.|..|
Human  1959 ELNDKIDDLSQEIKDRKLAEKVSQAESHAAQLN------DSSAVLDGILDEAKNISFNATAAFKA 2017

  Fly  1172 -DSNREMVSLKEENARILSELFHKKEEVGNLQAEIRGL--ESAQANLHAEIDSLQDTLAEKEQFY 1233
             .:.::.:...|:.|:...:|.|   |...|....|||  |.|:..|......|.:  |:|
Human  2018 YSNIKDYIDEAEKVAKEAKDLAH---EATKLATGPRGLLKEDAKGCLQKSFRILNE--AKK---- 2073

  Fly  1234 VQRDIKSNATLAQHKKLIDYLQLKVEDLSAKK---KKTLADKLFGSSHTNKENVSPNDVESSILY 1295
            :..|:|.|   ..|   ::.|:.::|:..|:.   .:||.|.|      .|.:..|||..:.:
Human  2074 LANDVKEN---EDH---LNGLKTRIENADARNGDLLRTLNDTL------GKLSAIPNDTAAKL-- 2124

  Fly  1296 RALKEELKREQKMNSLLKEQLAQ-------LNG---------------TATLRSPRKSAAVNGDS 1338
            :|:|:   :.::.|...|:.|||       |:|               .|.::.|.|:..: .|:
Human  2125 QAVKD---KARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKII-ADA 2185

  Fly  1339 DA-------------PKQRPVSIAALPRSPQKQQQPLKRTTSQV-ELKTTAEKPT---KVTIEN- 1385
            ||             .|.:|:         ::.:..||:..|:: ||...|.|..   ||::.:
Human  2186 DATVKNLEQEADRLIDKLKPI---------KELEDNLKKNISEIKELINQARKQANSIKVSVSSG 2241

  Fly  1386 -QAHHRFELALQESKVDAVNCVVCEKAVVAGSPFWKCKECKDVTHRKCRSNVQSHCGSTKPTAPS 1449
             .....::..:::...:  |.||..|..||                   .|:..:.||.|
Human  2242 GDCIRTYKPEIKKGSYN--NIVVNVKTAVA-------------------DNLLFYLGSAK----- 2280

  Fly  1450 ADDLSSIQ----SVSSLTLDSVDVAGGT--------TSGGEYIGSLVYSSDG--------AEDQA 1494
            ..|..:|:    .||.|.    ||..|.        |....|...:|.|..|        |.|..
Human  2281 FIDFLAIEMRKGKVSFLW----DVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGP 2341

  Fly  1495 RKEIEVNCAFEVAEQQILLLGCNTGLYAYHLDSQRLVHISGLESVSCMSICKRLAKAIMV----- 1554
            :..|..:.....:.....:|         .:|:..::.:.||..        :|.||..|
Human  2342 KASIVPSTHHSTSPPGYTIL---------DVDANAMLFVGGLTG--------KLKKADAVRVITF 2389

  Fly  1555 -GTVGEKLYQ------CDYRQLESRCQSSSSCHKPVLETS------------AIELP-------- 1592
             |.:||..:.      .::|:.|..|:..:.  .|.:|.|            .:..|
Human  2390 TGCMGETYFDNKPIGLWNFREKEGDCKGCTV--SPQVEDSEGTIQFDGEGYALVSRPIRWYPNIS 2452

  Fly  1593 ---FANRTPSEKWKLVLISDEAENALDSVAIAATSTRIVILKYDL----------------KLHM 1638
               |..||.|....|:.::  ..:..|.:::..|...|.: .|||                |...
Human  2453 TVMFKFRTFSSSALLMYLA--TRDLRDFMSVELTDGHIKV-SYDLGSGMASVVSNQNHNDGKWKS 2514

  Fly  1639 FKPVRALDTAT-PVTSIFFTRHSAIVSSDKFYEIDLDNYAAEEFV-----DLSDKSMESTAKCQP 1697
            |...|....|. .:..|...:...|.:|.......||..|.::..     .|.:.||    |.:|
Human  2515 FTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLSM----KARP 2575

  Fly  1698 ----------LTAVRISRQEY-LLCFAEY-GVFVDEFGCRSRPYDLNWVYAPT----GFVYRDPF 1746
                      |..:.|||..| :|...:| ||   ..||     .|..||..:    |||...|
Human  2576 EVNLKKYSGCLKDIEISRTPYNILSSPDYVGV---TKGC-----SLENVYTVSFPKPGFVELSP- 2631

  Fly  1747 LFISHYQSVQI---VRLHRSFSKEMASG 1771
                    |.|   ..::.|||.:..||
Human  2632 --------VPIDVGTEINLSFSTKNESG 2651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357
		S_TKc	113..383	CDD:214567
		Smc	487..1222	CDD:224117	106/507 (21%)
		CNH	1503..1774	CDD:279162	69/345 (20%)
LAMA2	XP_016866340.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910