Protein Alignment sti and Pdk1

DIOPT Version :10

• Sequence 1: NP_001261768.1
• Gene: sti / 39429
• FlyBaseID: FBgn0002466
• Length: 1858
• Species: Drosophila melanogaster
• Sequence 2: NP_728471.2
• Gene: Pdk1 / 38017
• FlyBaseID: FBgn0020386
• Length: 836
• Species: Drosophila melanogaster
• Alignment Length: 558
• Identity: 143/558 - (25%)
• Similarity: 221/558 - (39%)
• Gaps: 157/558 - (28%)

  Fly   107 RVNADDFLIKTLIGQGYFGNVHLVVERQTNDIYAMKKIKKSVVTTSQ----VKEERDIM-SIRNS 166
            |.:.:||:....||:|.:..|:|.|:..:...||:|..:|.::...:    :|.||::| .:.|.
  Fly   240 RRSPNDFIFGRYIGEGSYSIVYLAVDIHSRREYAIKVCEKRLILRERKQDYIKREREVMHQMTNV 304

  Fly   167 EWLINLQYAFQDNDNLYLVMEYMPGGDLLSLMSRHGPFDEDLARFYLAELTVALHTLHEMGYVHR 231
            ...:||...|||..:||.||.|...||:|..::|.|.||....|.|.|||.:|...:|....|||
  Fly   305 PGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRVGSFDVACTRHYAAELLLACEHMHRRNVVHR 369

  Fly   232 DIKPENILIDRFGHIKLADFGNAAAL--------------------------------------D 258
            |:||||||:|...|..:||||:|..:                                      |
  Fly   370 DLKPENILLDEDMHTLIADFGSAKVMTAHERALATEHCSEQRRSNSDEDDEDSDRLENEDEDFYD 434

  Fly   259 RDGHVL--------------------------SLSPVGTPDYIAPELLQT--ISTYKLSKSMHDV 295
            ||...|                          ..|.|||..|::||:||.  |:.
  Fly   435 RDSEELDDGDDEQQQEEMDSPRHRQRRYNRHRKASFVGTAQYVSPEVLQNGPITP---------- 489

  Fly   296 SRIVSCDYWSMGIIGYELICETTPFHEDNVHETYSKILSHCEESHLKELISFPADLKVSVNYRNL 360
                :.|.|::|.|.|::|....||...|.:..:.:||. |       .:.||...  ..:..:|
  Fly   490 ----AADLWALGCIVYQMIAGLPPFRGSNDYVIFKEILD-C-------AVDFPQGF--DKDAEDL 540

  Fly   361 IESLV-TNPSKRLS-------YERIKNHPFFSEIPWGSIRSQVP----PIIPTVRSDDDTSNFED 413
            :..|: .:|..||.       ||.|:.||||:.|.|.::|.|.|    |.:|.|..|:|   |..
  Fly   541 VRKLLRVDPRDRLGAQDEFGYYESIRAHPFFAGIDWQTLRQQTPPPIYPYLPGVSQDED---FRS 602

  Fly   414 GIRHKTRREQGVAKKSLTTNMKSNDFSGKDLPFIGYSFVHMEKSAISATTDEKLQEKLKELLQKL 478
            ........|.|:.::.::..:.:....|..:.      :.:::|....:.|....|||:.|.|
  Fly   603 SYTVPGDLEPGLDERQISRLLSAELGVGSSVA------MPVKRSTAKNSFDLNDAEKLQRLEQ-- 659

  Fly   479 KTRENEISMLKQDLLRAQQSLRKTDNKSQVVADAKMEIK-----KLQQIIKEKTMELTTCKTQIK 538
                                 :||| |..|.||.::.:|     |.:.:...|.|.|.|...::.
  Fly   660 ---------------------QKTD-KWHVFADGEVILKKGFVNKRKGLFARKRMLLLTTGPRLI 702

  Fly   539 TLQ--SSAKIDEEMWSKKEATITDLLRLNRQKYEEAKI 574
            .:.  ...|..|..||      .||    |.:|:..||
  Fly   703 YIDPVQMIKKGEIPWS------PDL----RAEYKNFKI 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	Protein Kinases, catalytic domain	111..452	CDD:473864	112/423 (26%)
		SMC_prok_B	481..1254	CDD:274008	23/101 (23%)
		C1	1389..1440	CDD:410341
		CNH	1509..1779	CDD:459938
Pdk1	NP_728471.2	STKc_PDK1	244..571	CDD:270733	96/350 (27%)
		PH_PDK1	658..764	CDD:241293	24/107 (22%)