Protein Alignment sti and ERC1

DIOPT Version :9

• Sequence 1: NP_001261768.1
• Gene: sti / 39429
• FlyBaseID: FBgn0002466
• Length: 1858
• Species: Drosophila melanogaster
• Sequence 2: XP_016874541.1
• Gene: ERC1 / 23085
• HGNCID: 17072
• Length: 1141
• Species: Homo sapiens
• Alignment Length: 1198
• Identity: 249/1198 - (20%)
• Similarity: 500/1198 - (41%)
• Gaps: 278/1198 - (23%)

  Fly   370 KRLSYERIK--NHPFFSEIPW-----GSIRSQVPPIIPTVRSDDDTSNFEDGIRHKTRREQGVAK 427
            |.||.|.|:  |..:.:..|.     .::.|:.|....|:.            |...|...||..
Human    52 KTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMTLG------------RSGGRLPYGVRM 104

  Fly   428 KSL--TTNMKSNDFSGKDLPFIGYSFVHMEKSAISATTDEKLQEKLKELLQKLKTRENEISMLKQ 490
            .::  :.|:.|   ||.....|.:...|:...::::|....|::.....:..|:|:..|: :.:.
Human   105 TAMGSSPNIAS---SGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEV-LREN 165

  Fly   491 DLLRAQQSLRK---TDNKSQVVADAKMEIKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEEMWS 552
            ||||....:::   :.:.:.:......|:||.:.:.|::..::|..|.|.:.:|..   ::.|..
Human   166 DLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEE---NQHMQM 227

  Fly   553 KKEATITDLLRLNR---QKYEEAKIA----------SEQRYEKQLADKKQE------LASTLQKL 598
            ..:| :.|.||:.|   |.:::...:          :|:.:::..|:.:::      |..||:::
Human   228 TIQA-LQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEM 291

  Fly   599 DARELEFNAKFEECKH-LSMKLQNYKDMLQQIKEQNLK---SETNHEEQRR-QMAELYEQKLTDL 658
            :.|       .|..|. |:.:.::.|.:|:.::.:.|.   :|.:||..|| ..||::...|..|
Human   292 ELR-------IETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESL 349

  Fly   659 RKKVRDSQDTNRRMTMEIKEIRTELDESISSSKSTQ---EAKNATERNIEEILRRLNEEI---AS 717
                .:.::....|..|....|.|.....:.:|:.|   |.|::...::|..||.|.|||   .|
Human   350 ----LEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKS 410

  Fly   718 NNELHAEKVKLETK-LQLKENETQEVRAECHRLERELQLAECRCQLAESSLATQVSPYETAPGSL 781
            |..|..|:.:.|.| :::..:.::.::.:..:|:.||...|.:.:
Human   411 NGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWE-------------------- 455

  Fly   782 TELNAIEDQLRADLLAAKESENHQKGRADQLQTLVTKLEQMLERFNE---------QSLSPTKSH 837
             ||......|:|::.|..:.:.....:..:|..|.||||.:..:|::         :||:..:..
Human   456 -ELKKKAAGLQAEVFAIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQR 519

  Fly   838 SS-----------RKQEGETVGDMLERQNEKLED----------KLAAVREQMIVERQAARTANL 881
            ::           |.:|.||   ||.::.::::|          ::..:::.:.|:.   |..|:
Human   520 AAILQTEVDALRLRLEEKET---MLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKE---RKVNV 578

  Fly   882 SLWKVEKQLEEALSEKKLLARRMELTEDRIKKVQNASDEAQRMLKTSQEETRQRESRIEELKQEL 946
            ...|:| .|:|.|.:|:   ::|...::|:|.:|..:......|.|.:|...::|..||.||::.
Human   579 LQKKIE-NLQEQLRDKE---KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQR 639

  Fly   947 AAAKRDVLKEHRQWEKAEQERMKCKSEIIEHLANVHRLEQQETELRQKLRQIQSRFDGVTLEQKN 1011
            ...:|:..:|...::| :.:.:|.|..:::     ..|.::|..|.. |::..|......|::.:
Human   640 DRDEREKQEEIDNYKK-DLKDLKEKVSLLQ-----GDLSEKEASLLD-LKEHASSLASSGLKKDS 697

  Fly  1012 TIRELQEEREKSRKANDSCLVLQKELKQLTDNFQRLKYACSITDSQLTEVETMLKSEQERNKSQK 1076
            .::.|:...|:.:   :.||.::.:||:..:.....:.:..::| ::..:|..:...::.:...:
Human   698 RLKTLEIALEQKK---EECLKMESQLKKAHEAALEARASPEMSD-RIQHLEREITRYKDESSKAQ 758

  Fly  1077 SQLDTLHEKLRERNDQLTDLRKQLTTVES--EKRLAEQRAQVLASEIDELRLNLKEQ-QKKLVAQ 1138
            :::|.|.|.|:|..::..|..|::..:||  .:::.:|..:|       ..|..||| :||..||
Human   759 AEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKV-------ANLKHKEQVEKKKSAQ 816

  Fly  1139 --------QDQLVEQT----NALFATQERAELLDGQNANYEAQTADSNREMVSLKEENAR----- 1186
                    :|.|.:.:    ::|....:|.|.|  :.|..|:....:.||||..:||:||
Human   817 MLEEARRREDNLNDSSQQLQDSLRKKDDRIEEL--EEALRESVQITAEREMVLAQEESARTNAEK 879

  Fly  1187 -ILSELFHKKE-------EVGNLQAEIRGLESAQANLHAEIDSLQDTLAEKEQFYVQRDIKSNAT 1243
             :|.|:.|:..       :|..|...:..::....::.|::.|.|.:|||||...      :|..
Human   880 QLLREILHETSYLNFKWFKVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHL------TNLR 938

  Fly  1244 LAQHKKLIDYLQLKVE----------------DLSAKKKKT------------------------ 1268
            ..:.|.|.:.|::|.|                :||:.||||
Human   939 AERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQN 1003

  Fly  1269 ----LADKL----FGSSHTNKEN--VSPNDVESSILYRALKEELKREQKMNSLLKEQLAQLNGTA 1323
                :||..    |.|||:|:.|  .||:.:...:|      ||.:.:   |.||..:..|....
Human  1004 RMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLL------ELDQNR---SKLKLYIGHLTTLC 1059

  Fly  1324 TLRSP------RKSAAVNGDSDAPKQRPVSIAALPRSPQK------QQQPLKRTTSQVELKTTAE 1376
            ..|.|      ...|:.|.|.|.        ||.....||      |.:..|......||:..|
Human  1060 HDRDPLILRGLTPPASYNLDDDQ--------AAWENELQKMTRGQLQDELEKGERDNAELQEFA- 1115

  Fly  1377 KPTKVTIENQAHHRFEL------ALQES 1398
               ...::..|.|..::      ||:||
Human  1116 ---NAILQQIADHCPDILEQVVNALEES 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	19/90 (21%)
		S_TKc	113..383	CDD:214567	6/14 (43%)
		Smc	487..1222	CDD:224117	167/826 (20%)
		CNH	1503..1774	CDD:279162
ERC1	XP_016874541.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910