DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sti and tpa-1

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	NP_001379590.1	Gene:	tpa-1 / 176825	WormBaseID:	WBGene00006599	Length:	704	Species:	Caenorhabditis elegans

Alignment Length:	357	Identity:	117/357 - (32%)
Similarity:	178/357 - (49%)	Gaps:	40/357 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 FLIKTLIGQGYFGNVHLVVERQTNDIYAMKKIKKSVV-----TTSQVKEERDIMSIRNSEWLINL 172
            |.:..::|:|.||.|.||..:..|:.||||.:||.|:     |.....|.|.::......:|..|
Worm   375 FNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTYIERRVLILASQCPFLCQL 439

  Fly   173 QYAFQDNDNLYLVMEYMPGGDLLSLMSRHGPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPEN 237
            ..:||.|:.|:.||||:.||||:..:.:...|||...|||..|:.|||..||....::||:|.:|
Worm   440 FCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDEARTRFYACEIVVALQFLHTNNIIYRDLKLDN 504

  Fly   238 ILIDRFGHIKLADFGNA-AALDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSMHDVSRIVSC 301
            :|:|..|||||||||.| ..::|:..:.| :..||||||:||:::. ..|.           .:.
Worm   505 VLLDCDGHIKLADFGMAKTEMNRENGMAS-TFCGTPDYISPEIIKG-QLYN-----------EAV 556

  Fly   302 DYWSMGIIGYELICETTPFHEDNVHETYSKILSHCEESHLKELISFPADLKVSVNYRNLIESLVT 366
            |:||.|::.||::...:|||.:...|.:..||:  |..:..:.||..|...:|..:..
Worm   557 DFWSFGVLMYEMLVGQSPFHGEGEDELFDSILN--ERPYFPKTISKEAAKCLSALFDR------- 612

  Fly   367 NPSKRLSYER-----IKNHPFFSEIPWGSI--RSQVPPIIPTVRSDDDTSNFEDGIRHKTRREQG 424
            ||:.||....     |:.|.||..:.|...  |...||..|.::|:.|.|||:|...::......
Worm   613 NPNTRLGMPECPDGPIRQHCFFRGVDWKRFENRQVPPPFKPNIKSNSDASNFDDDFTNEKAALTP 677

  Fly   425 VAKKSLTTNMKSNDFSGKDLPFIGYSFVHMEK 456
            |..|:|..::....|    |.| .|:..|..|
Worm   678 VHDKNLLASIDPEAF----LNF-SYTNPHFSK 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	115/351 (33%)
		S_TKc	113..383	CDD:214567	95/280 (34%)
		Smc	487..1222	CDD:224117
		CNH	1503..1774	CDD:279162
tpa-1	NP_001379590.1	C1_nPKC_theta-like_rpt1	159..219	CDD:410384
		C1_nPKC_theta-like_rpt2	238..287	CDD:410387
		STKc_nPKC_theta_like	379..700	CDD:270744	114/347 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910