Protein Alignment sti and DMPK

DIOPT Version :10

• Sequence 1: NP_001261768.1
• Gene: sti / 39429
• FlyBaseID: FBgn0002466
• Length: 1858
• Species: Drosophila melanogaster
• Sequence 2: NP_001411092.1
• Gene: DMPK / 1760
• HGNCID: 2933
• Length: 656
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 198/633 - (31%)
• Similarity: 303/633 - (47%)
• Gaps: 133/633 - (21%)

  Fly    23 GAGVCAKPA-GSASGSGI----PASTRRSIVPVSTTSAAVAEAICREGLLDAFCLLYNECDKDTL 82
            |||..|:|: |...|:|.    |...|..::.|...| .|.:::.:|
Human    27 GAGAPARPSPGRPPGAGRLRTGPGQVRGRLLAVGPKS-RVFQSVVQE------------------ 72

  Fly    83 KKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGYFGNVHLVVERQTNDIYAMKKIKK- 146
            .....:.||      ||:...:::|:..|||.|..:||:|.|..|.:|..:||..:||||.:.|
Human    73 PPASESRAE------PIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKW 131

  Fly   147 SVVTTSQV---KEERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYMPGGDLLSLMSRHGP-FDED 207
            .::...:|   :||||::...:..|:..|.:||||.:.|||||||..|||||:|:|:.|. ...:
Human   132 DMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAE 196

  Fly   208 LARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLADFGNAAALDRDGHVLSLSPVGTP 272
            :|||||||:.:|:.::|.:|||||||||:|||:||.|||:|||||:...|..||.|.||..||||
Human   197 MARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTP 261

  Fly   273 DYIAPELLQTISTYKLSKSMHDVSRIVSCDYWSMGIIGYELICETTPFHEDNVHETYSKILSHCE 337
            ||::||:||.:.....:.|...     .||:|::|:..||:....|||:.|:..|||.||:
Human   262 DYLSPEILQAVGGGPGTGSYGP-----ECDWWALGVFAYEMFYGQTPFYADSTAETYGKIV---- 317

  Fly   338 ESHLKELISFP-ADLKVSVNYRNLIESLVTNPSKRL---SYERIKNHPFFSEIPWGSIRSQVPPI 398
              |.||.:|.| .|..|....|:.|:.|:..|..||   .....:.||||..:.|..:|..|||.
Human   318 --HYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDSVPPF 380

  Fly   399 IPTVRSDDDTSNF---EDGIRHKTRREQGVAKKSLTTNMKSNDFSGKDLPFIGYSF--VHMEKSA 458
            .|......||.||   |||:   |....|..:  ..::::.....|..|||:|||:  :.:..|.
Human   381 TPDFEGATDTCNFDLVEDGL---TAMVSGGGE--TLSDIREGAPLGVHLPFVGYSYSCMALRDSE 440

  Fly   459 ISATTDEKLQEKLKELLQKLKTRENEISMLKQDLLRAQQSLRKTDNKSQVV---------ADAKM 514
            :...|..:|:.:     |.|:......|:        :.|:...|..::|.         |:|::
Human   441 VPGPTPMELEAE-----QLLEPHVQAPSL--------EPSVSPQDETAEVAVPAAVPAAEAEAEV 492

  Fly   515 EIKKLQQIIKEKTMELTTCKTQIKTLQSSAKIDEEMWSKKEATITDLLRLNRQKYEEAKIASEQR 579
            .:::||:.::|          ::.|.||   :..||    ||..||
Human   493 TLRELQEALEE----------EVLTRQS---LSREM----EAIRTD------------------- 521

  Fly   580 YEKQLADKKQELASTLQKLDARELEFNAKFEECKHLSMKLQNYKDMLQ 627
                    .|..||.|::.:||..:..|...:       ||...::||
Human   522 --------NQNFASQLREAEARNRDLEAHVRQ-------LQERMELLQ 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	Protein Kinases, catalytic domain	111..452	CDD:473864	145/354 (41%)
		SMC_prok_B	481..1254	CDD:274008	29/156 (19%)
		C1	1389..1440	CDD:410341
		CNH	1509..1779	CDD:459938
DMPK	NP_001411092.1	STKc_DMPK_like	95..432	CDD:270748	145/352 (41%)
		DMPK_coil	496..556	CDD:117396	23/110 (21%)