Protein Alignment sti and citk-1

DIOPT Version :10

• Sequence 1: NP_001261768.1
• Gene: sti / 39429
• FlyBaseID: FBgn0002466
• Length: 1858
• Species: Drosophila melanogaster
• Sequence 2: NP_496914.1
• Gene: citk-1 / 175043
• WormBaseID: WBGene00012198
• Length: 1256
• Species: Caenorhabditis elegans
• Alignment Length: 1327
• Identity: 272/1327 - (20%)
• Similarity: 510/1327 - (38%)
• Gaps: 342/1327 - (25%)

  Fly   635 KSETNHEEQRRQMAELYEQKLTDLRKKVRDSQDTNRRMTMEIKEIRTELD---ESISSSKSTQEA 696
            ||::.......|:.:|..:...||:.::.::::.       |:::|:|.|   ||:.......|:
 Worm    16 KSKSARYSSPYQVIDLNNESQEDLKTRLLEAENI-------IQDLRSERDALHESLVDKAGLNES 73

  Fly   697 KNATERNIEEILRRLNEEIASNNELHAEKVK-LETKLQLKENETQEVRAECHRLERELQLAECRC 760
                     .|:.|.|:.......::...|. ||..|:.||::.:.::..|.|||.|.|
 Worm    74 ---------VIIERSNKVSTQETRIYRRDVTLLEDDLKQKESQIRILQNRCLRLETEKQ------ 123

  Fly   761 QLAESSLATQVSPYETAPGSLTELNAIEDQLRADLLAAKESENHQKGRADQLQTLVTKLEQML-- 823
                 .:...:|.|:            ||        .||:|.    |.:.|.:.:.|||..|
 Worm   124 -----KMQDTISGYQ------------ED--------LKENEI----RIENLNSRLHKLEDELSA 159

  Fly   824 ---ERFN--EQSLSPTKSHSSRKQEGETVGDMLERQNEKLEDKLAAVREQMIVERQAARTANLSL 883
               |.|:  |:..:.|...:.:..:.:|....:..:|..||.|:...||::||:.|    .:|.:
 Worm   160 KTHEIFSIGEELKNKTMKLNEKNSQFQTKLAEISSENRNLERKVQKFREELIVKDQ----RSLEV 220

  Fly   884 WKVEKQLEEALSEKKLLARRME-LTEDR--IKKVQNASDEAQ---RMLKTSQEETRQRESRIE-E 941
            .:.::..::.|.|.|.|:.|:: ||..|  :.:::...|..|   ::::.:..|.:.:.:|:| |
 Worm   221 HQDQENTQKVLKEVKQLSDRLDYLTPKRKDVSRIKERDDFLQFSAKIIEETMSELKLKNARLERE 285

  Fly   942 L--KQELAAAKRDVLKEHRQWEKAEQERMKCKSEIIEHL-ANVHRLEQQETELRQKLRQIQSRFD 1003
            |  |:||....::.|:|   .:|...:.|....:..::| |...:|.:|:.::|..|
 Worm   286 LSEKEELVKVTKEELQE---LQKTVTQAMGDSEQATKYLHAENMKLTRQKADIRCDL-------- 339

  Fly  1004 GVTLEQKNTIRELQEEREKSRKANDSCLVLQKELKQLTDN----FQRLKYACSITDSQLTEVET- 1063
               ||.:..::...|:||:..|..|..|...:.:.:|..|    .:.||......:.|:.|:::
 Worm   340 ---LEARRNLKGFDEKREELEKQRDEALEDVRRITELKKNVEIELRSLKLLAEEREEQIDELKSR 401

  Fly  1064 -----MLKSEQERNKSQKSQLDTLHEKLRERNDQLTDLRKQLT-------TVESEKRLAEQRAQV 1116
                 :|:.:.|   :.|::|....|||.:....|....||.:       |.|..:|.|.::...
 Worm   402 VAGYEVLRRDHE---AVKNELAKAEEKLNKMGAHLVMADKQSSHFKTLKETAEGSRRRAIEQCNE 463

  Fly  1117 LASEIDELRLNLKEQQKKLVAQQDQLVEQTNALFATQERAELLDGQNANYEAQTADSNREMVSLK 1181
            :.:.|..|..:|:.|:|         |||                              |:..:|
 Worm   464 MVARIRGLEASLENQRK---------VEQ------------------------------ELEMVK 489

  Fly  1182 EENARILSELFHKKEEVGNLQAEIR----------GLESAQANLHAEIDSLQDTLAEKEQFYVQR 1236
            .||.|...::...|||:.....:.|          |...|.:...:|:.|.:.|:.|     |:.
 Worm   490 AENVRQAKKIEFMKEEIQETHLDYREELSKLAKGGGSHEADSQRDSELRSAKKTIQE-----VKA 549

  Fly  1237 DIKSNATLAQHKKLIDYLQLKVEDLSAKKKKTLADKL-----FGSS-HTNKE-----NVSPNDVE 1290
            |   |..|.|..:.:...|.||.:.:.|.:|.:|:.:     |..: |:::|     .:...:.|
 Worm   550 D---NKKLQQILEEVRQNQSKVLEENVKLRKGMAEAIEKIEEFKRNWHSSREAGERLQLEAKENE 611

  Fly  1291 SSILYRALKEELKREQKMNSLLKEQL-----AQLNGTATLRSP---RKSAAVNGDSDAPKQRPVS 1347
            ..:|  .::||| :|:::..|.||:|     :|:| |...:.|   |:|..::..|:......|.
 Worm   612 EKVL--KVEEEL-QEKRLEVLEKEELVNYLQSQIN-TKQTKQPKLSRRSTLMSTISEVDTSTYVR 672

  Fly  1348 IAALPRSPQKQQQPLK---------------RTTSQVELKTTAEKPTKV------------TIEN 1385
            .....|:.::|::.|:               |:|:......|:...|:|            |:.:
 Worm   673 EVEEVRALEEQREELQAYLAEKRKMADLQKSRSTANTTTLITSTTATEVSKSACELSYPPATMRH 737

  Fly  1386 QAHHRFELALQESKVDAVNCVVCEKAVVAGSPFWKCKECKDVTHRKCRSNVQSHCGSTKPTAPSA 1450
            ...|:: |..:...|.::.|.:|...:...:...||..|....|..|...|.:.||.....|...
 Worm   738 DIPHKW-LEFRHYSVLSMKCSLCFVGITFFTKANKCSHCDVRVHASCAPRVNNTCGIPAQCATYY 801

  Fly  1451 DDLSSIQSVSSLT---------------------LDSVDVAGGTTSGGEYIGSLVYSSD------ 1488
            .|..::..:..:.                     :||..|.....:|.:.:.:..::.|
 Worm   802 QDAQAVGGIGRMNGWLRVYRDDLPESTWTSLWAMMDSNHVKFYRDAGADNLENPYFTIDLNKEQW 866

  Fly  1489 ----GAE----------------------------------------DQARKEIEVNCAFEVAEQ 1509
                |.|                                        .|.|:.::.:....:||.
 Worm   867 ILRTGQEVAIPGDVMRNVLTIKLQTRSVHIVAPTPKSAERWAACLQNAQTRRMMKNSKPSSIAEY 931

  Fly  1510 QIL---------------------LLGCNTGLYAYHLDSQR-LVHISGLESVSCMSICKRLAKAI 1552
            ..|                     |....|||:...:...| ...|:|..||:.:.:...:....
 Worm   932 SCLLTLSLPNNLKIFKAHTIEDWILFATQTGLFFTSISQPRNPTRIAGPSSVTSLEVMSEINCVA 996

  Fly  1553 MVGTVGEKLYQCDYRQLESRCQSSSSCHKPVLETSAIELPFANRTPSEKW------KLVLISDEA 1611
            |:.....:|...   .|:|...:..|.|..:   .|..||......:.::      :.:|:||:
 Worm   997 MITNSNRQLALI---PLDSLTLAMQSTHPSI---RAEVLPEFGHVHTIRYHQQDGQRFLLVSDD- 1054

  Fly  1612 ENALDSVAIAATSTRIVILKYDLKLHMFKPVRALDTATPVTSIFFTRHSAIVSSDKFYEIDLDNY 1676
                         |::.|.||:....:|.....|....||:.|..|....|.:||.||.:.||:.
 Worm  1055 -------------TQLHIRKYNSTRDVFAHFAKLVVPEPVSFIESTPAGFIFASDTFYYVPLDHQ 1106

  Fly  1677 AAEEFVDLS-DKSMESTAKCQPLTAVRISRQEYLLCFAEYGVFVDEFGCRSRPYDLNWVYAPTGF 1740
            :..   |:| .|.|.......|::|..|:..|.||.:..:|:||:.:|.:||...:.|...|..|
 Worm  1107 SPS---DVSARKLMPPRRSDYPVSAHAITANEILLAYQNHGIFVNLYGEQSRNQIIEWEKMPIEF 1168

  Fly  1741 VYRDPFLFISHYQSVQIVRLHRSFSKE 1767
            .|..|.|:|.|..|::||::.:| |||
 Worm  1169 AYTSPLLYIVHDDSIEIVQISKS-SKE 1194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	Protein Kinases, catalytic domain	111..452	CDD:473864
		SMC_prok_B	481..1254	CDD:274008	140/666 (21%)
		C1	1389..1440	CDD:410341	11/50 (22%)
		CNH	1509..1779	CDD:459938	70/288 (24%)
citk-1	NP_496914.1	SMC_prok_B	91..>699	CDD:274008	154/714 (22%)
		CRIK	737..794	CDD:410364	13/57 (23%)
		PH	813..915	CDD:214574	7/101 (7%)
		CNH	941..1222	CDD:214481	69/278 (25%)