DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sti and AgaP_AGAP003618

DIOPT Version :9

Sequence 1:	NP_001261768.1	Gene:	sti / 39429	FlyBaseID:	FBgn0002466	Length:	1858	Species:	Drosophila melanogaster
Sequence 2:	XP_003436539.1	Gene:	AgaP_AGAP003618 / 1274280	VectorBaseID:	AGAP003618	Length:	1430	Species:	Anopheles gambiae

Alignment Length:	475	Identity:	159/475 - (33%)
Similarity:	233/475 - (49%)	Gaps:	108/475 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GKGAGVCAKPAGSASGSGIPASTRR----SIVPVSTTSAAVAEAICREGLL-----DAFCLLYNE 76
            |.|||      ||..|.|...:.|:    |.:|.....:...||...|..:     .|:.....:
Mosquito   914 GGGAG------GSGGGGGGEDNPRKIKHQSPIPERKNLSKEKEAERSECKVKHYSPQAYKFFMEQ 972

  Fly    77 CDKDTLK---KRDRNIAEFVNKFR--PIIEET----RKL------------RVNADDFL---IKT 117
            ..::.||   :|:..|.:..::..  .:.|||    |||            |...|..:   |||
Mosquito   973 HIENVLKSYSQRNFRIKQLESEMSKLDLPEETKIEMRKLLCQKESNYIRLKRAKMDKSMFAKIKT 1037

  Fly   118 LIGQGYFGNVHLVVE-RQTNDIYAMKKIKKSVV----TTSQVKEERDIMSIRNSEWLINLQYAFQ 177
             ||.|.||.|.||.: ..||.:||||.::|:.|    ..:.||.||||::..::||::.|.|:||
Mosquito  1038 -IGVGAFGEVTLVKKIDTTNHLYAMKTLRKADVLKRNQVAHVKAERDILAEADNEWVVKLYYSFQ 1101

  Fly   178 DNDNLYLVMEYMPGGDLLSLMSRHGPFDEDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDR 242
            |.||||.||:|:|||||:||:.:.|.|:|||||||:||||.|:.::|:||::||||||:|:||||
Mosquito  1102 DKDNLYFVMDYIPGGDLMSLLIKKGIFEEDLARFYIAELTCAIDSVHKMGFIHRDIKPDNVLIDR 1166

  Fly   243 FGHIKLADFG--------------------NAAALD----------------------RDGHVLS 265
            .|||||.|||                    |.|..|                      ......:
Mosquito  1167 KGHIKLTDFGLCTGFRWTHDSKYYQKNGMLNHARQDSMEAWSKFGPDIPPPLERRKFREKNRAKA 1231

  Fly   266 LSPVGTPDYIAPELLQTISTYKLSKSMHDVSRIVSCDYWSMGIIGYELICETTPFHEDNVHETYS 330
            .|.||||:|||||:|......:|            ||:||:|:|.||::....||..:...||..
Mosquito  1232 HSIVGTPNYIAPEVLMRSGYTQL------------CDWWSVGVILYEMLVGQPPFLANTAEETQI 1284

  Fly   331 KILSHCEESHLKELISFPADLKVSVNYRNLIESLVTNPSKRL--SYERIKNHPFFSEIPW-GSIR 392
            |::      :.::.:..|.|..::....::|..|..|..:|:  :.:.||:||||..|.: ..:|
Mosquito  1285 KVI------NWRQTLRIPVDAHLTPEAMDIILRLCKNEDERIGRNVDEIKSHPFFRTIDFTKDLR 1343

  Fly   393 SQVPPIIPTVRSDDDTSNFE 412
            ||.....|.::...|||||:
Mosquito  1344 SQQALYEPKIKYPTDTSNFD 1363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	133/355 (37%)
		S_TKc	113..383	CDD:214567	120/321 (37%)
		Smc	487..1222	CDD:224117
		CNH	1503..1774	CDD:279162
AgaP_AGAP003618	XP_003436539.1	STKc_LATS	1030..1382	CDD:270749	132/353 (37%)
AgaP_AGAP003618	XP_003436539.1	S_TKc	1032..1333	CDD:214567	120/319 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920