DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sti and dgkk

DIOPT Version :9

Sequence 1:NP_001261768.1 Gene:sti / 39429 FlyBaseID:FBgn0002466 Length:1858 Species:Drosophila melanogaster
Sequence 2:XP_004916836.1 Gene:dgkk / 100496859 XenbaseID:XB-GENE-22063413 Length:1154 Species:Xenopus tropicalis


Alignment Length:1369 Identity:250/1369 - (18%)
Similarity:461/1369 - (33%) Gaps:442/1369 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 DTLKKRDRNIAEFVNKFR-PIIEETRKLRVNADDFLIKTLIGQGYFGNVHLVVER--QTNDIYAM 141
            |..|:|.|:....::..: |..|.|.:...:::        |:...|..|.::.:  .:..|.:.
 Frog     9 DAFKRRARDSVSSLDSDKLPTAEATGEESSDSE--------GEEQEGISHKLIRKVSTSGQIRSK 65

  Fly   142 KKIKKSVV---TTSQVKEERDIMSIRNSEWLINLQYAFQDNDNLYLVMEYMPGGDLLSLMSRHGP 203
            |.:|:.::   |:|..:.:|....:|..    .|.|| :|:.:|.                    
 Frog    66 KSVKEGILLKQTSSFQRWKRRYFKLRGR----TLYYA-KDSKSLI-------------------- 105

  Fly   204 FDE-DLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIKLADFGNAAALDRDGHVLSLS 267
            ||| ||:...:||.:.            ::|.....:|..|..:.|      .|.:|        
 Frog   106 FDEVDLSDASVAETST------------KNINNSFTVITPFRKLIL------CAENR-------- 144

  Fly   268 PVGTPDYIAPELLQTISTYKLSKSMHD-VSRIVSCDYWSMGIIGYELICETTPF---HEDNVHET 328
                                  |.|.| :..:.|...|.:.        |||.|   |...:|..
 Frog   145 ----------------------KEMEDWIGALKSVQKWELN--------ETTQFNMEHFSGMHNW 179

  Fly   329 YSKILSH--------CEE------SH--LKELISFPADLKVSVNYRN-------------LIESL 364
            |:  .||        |.|      ||  ..|:..|.|..:.:|...|             :||..
 Frog   180 YA--CSHARPTFCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASVGNDIIEDE 242

  Fly   365 --VTNPSKRL------------------SYERIKN----------HPFFSE-----IPWGSIR-S 393
              |:.|.:.|                  |..|:::          |....|     .|.|..| |
 Frog   243 DGVSMPHQWLEGNLPVSAKCEVCDKTCGSVRRLQDWRCLWCKAIVHTSCKEQLGKICPLGPCRVS 307

  Fly   394 QVPPIIPTVRSDDDTSNFEDGIRHKTRREQGVAKKSLTTNMKSNDFSGKDLPFIGYSFVHMEKSA 458
            .:|||  .:.|.|     .||....|......:...:..|.||.|..|                 
 Frog   308 IIPPI--ALNSID-----SDGFWKATSPASCASPLLVFVNSKSGDNQG----------------- 348

  Fly   459 ISATTDEKLQEKLKELLQKLKTRENEISMLKQDLLRA--QQSLR---KTDNKSQVV--ADAKM-- 514
                  .|...|.|:.|...:.         .||:..  |..||   |..|...:|  .|..:  
 Frog   349 ------VKFLRKFKQFLNPAQV---------FDLMNGGPQLGLRLFQKFSNFRILVCGGDGSVGW 398

  Fly   515 ---EIKK--LQQIIKEKTMELTT-------------CKTQIKTLQSSAKIDE------EMWSKKE 555
               ||.|  ||:..:...:.|.|             |....:.||...|::.      :.||   
 Frog   399 VLSEIDKLGLQKQCQLGVLPLGTGNDLARVLGWGSLCDDDAQLLQILEKLERATTKMLDRWS--- 460

  Fly   556 ATITDLLRLNRQKYEEAKIASEQ----RYEKQLADKKQELASTLQKLDARELEFNAKFEECKHLS 616
                 :|.....|:....|..|:    :::.|::.....:|..|.|:    ||.:...:......
 Frog   461 -----ILTYESPKHSPPAIREEENGEAKFQVQISQYADSVAFHLAKI----LESDKHCDVISSAK 516

  Fly   617 MKLQNYKDMLQQIKEQNLKSETNHEE--QRRQMAELYEQKLTDLRKKVRDSQDTNRRMTMEIKEI 679
            ....:..|.:.::.:...::..|.||  ...:...:..:||..|.:.:  ::::...:...::.:
 Frog   517 FLCLSVNDFITEVGKAYARAAENREEADNMARKCSMLNEKLESLVRSL--NEESQALLAPPLQSL 579

  Fly   680 RTELDESISSSKSTQEAKNATERNIEEILRRLNEEIASNNELHAEKVKLETKLQLKENETQEVRA 744
            ..:     |:.|...:..|..|.|:|::               |:..|.:.:|.|:.|..::.  
 Frog   580 HPD-----SALKENSKDVNEKENNMEDM---------------AKIFKSKEQLMLRANSLKKA-- 622

  Fly   745 ECHRLERELQLAECRCQLAESSLATQVSPYETAPGSLTELNAIEDQLRADLLAAKESENHQKGRA 809
                |::.::.||  ..:.|.:..|||  |.|     ..|:.|:.:...:.....||...::|..
 Frog   623 ----LKQIIEQAE--KAVDEQNKHTQV--YST-----PMLSPIQKESSEEFSKEGESLASRRGTI 674

  Fly   810 DQLQTLVTKLEQMLER--------FNEQSLSPTKSHSSRKQEGETVG----DMLERQNEKLEDKL 862
            ....:.:     :|:|        |:|.::..::..:.....|  :|    ..||..|::.|.. 
 Frog   675 SSTTSSI-----ILDRPYTFSPLHFSEDAIQFSERCTMNNYFG--IGLDAKISLEFNNKRDEHP- 731

  Fly   863 AAVREQMIVERQAARTANLSLWKVEKQLEEALSEKKLLARRMELTEDRIK------KVQNASDEA 921
                     ::.::||.|:..:.|       |..|:||.:..:..|.|:|      .:...|.:.
 Frog   732 ---------KKCSSRTRNMMWYGV-------LGTKELLQKTYKNLEQRVKLECDGEPISLPSLQG 780

  Fly   922 QRMLKT------------SQEETRQRESRIEELKQELAAAKRDVLKEHRQWEKAEQERMKCKSEI 974
            ..:|..            ::|:........::.|.|:.|....:             :|.....|
 Frog   781 IAVLNIPSYAGGINFWGGTKEDNNFGAPSFDDKKLEVVAVFGSI-------------QMAVSRVI 832

  Fly   975 -IEHLANVHRLEQ----QETELRQKLRQIQSRFDG---------VTLEQKNTIRELQEER----- 1020
             ::|    ||:.|    :.|.|.::...:|  .||         :.::.||..:.|..:|     
 Frog   833 NLQH----HRIAQCRVVKITILGEEGVPVQ--VDGEAWVQPPGILKIQHKNRAQMLTRDRAFENT 891

  Fly  1021 ----EKSRKANDSCLVL-------QKELKQLT-DNFQRLKYACSITDSQLTEVETMLK----SEQ 1069
                |..|| .||..|:       |:.::.|| :.|..|::..:.:::.::.:....|    .||
 Frog   892 LKSWEDKRK-GDSYRVMARPRLHSQQSMEYLTEEEFAHLQHLANTSENLISRIREAAKYHKAVEQ 955

  Fly  1070 ERNKSQKSQLDTLHEKLRERNDQLTDLRKQLTTVE---SEKRLAEQRAQVLASEIDELRLNLKEQ 1131
            |...:.......|:|....:.:...:|..:.|.|:   |.|.|..:....|.|          :|
 Frog   956 ELAHAVNGSFGVLNEAFSNKTNNSPELLSRNTAVDVAISVKALYTETKAFLES----------KQ 1010

  Fly  1132 QKKLVAQQDQLVEQTNALFATQERAELLDGQNANY------EAQTADSNREMVSLKEENARIL-- 1188
            |.:...:::.|:...||:....||  |.|....::      |..:...|:....|     ||:  
 Frog  1011 QWESPQEEEGLLCSLNAVGQDLER--LADIHWISHIIKPTEEESSGGGNKGSFKL-----RIIPK 1068

  Fly  1189 ----SELFHKKEEVGNLQAEIRGLESAQANLHAEIDSLQDTLAEKEQFYVQRDIK-SNATLAQHK 1248
                .|...|::...:|..:..|.|...|.|    |.|  .|.|.:..:::.||: |...|.:.:
 Frog  1069 PKKEKEKCQKQKSNSSLTVDKWGTEEVAAWL----DVL--GLGEYKDIFIRHDIQGSELVLLERR 1127

  Fly  1249 KLID 1252
            .|.|
 Frog  1128 DLKD 1131

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stiNP_001261768.1 PKc_like 111..452 CDD:304357 77/415 (19%)
S_TKc 113..383 CDD:214567 59/338 (17%)
Smc 487..1222 CDD:224117 153/853 (18%)
CNH 1503..1774 CDD:279162
dgkkXP_004916836.1 PH_DGK_type2 68..164 CDD:270093 28/176 (16%)
C1 177..226 CDD:237996 13/50 (26%)
C1 249..299 CDD:237996 5/49 (10%)
DAGKc 336..458 CDD:214487 29/153 (19%)
PS_II_S4 608..>662 CDD:132113 14/68 (21%)
DAGKa 706..863 CDD:214486 34/194 (18%)
SAM_superfamily 1087..1150 CDD:387673 14/51 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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