Protein Alignment Lmx1a and LHX3

DIOPT Version :10

• Sequence 1: NP_729801.1
• Gene: Lmx1a / 39406
• FlyBaseID: FBgn0052105
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_055379.1
• Gene: LHX3 / 8022
• HGNCID: 6595
• Length: 402
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 105/321 - (32%)
• Similarity: 156/321 - (48%)
• Gaps: 56/321 - (17%)

  Fly   270 KNFELCEGCGQKIHDRFLMNVGDANWHEQCLACCYCGMQLHHTCYVRNSKLYCKMDYDRLFGVKC 334
            :...||.||.|.|.|||::...|.:||.:||.|..|...|...|:.|...:|||.|:.:.||.||
Human    31 REIPLCAGCDQHILDRFILKALDRHWHSKCLKCSDCHTPLAERCFSRGESVYCKDDFFKRFGTKC 95

  Fly   335 SSCCHAILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQF-MLRDGQLFCYRHDLEKEMFLAA 398
            ::|...|.|.::|.| ..:||:||.||.|..|:..|..|::| ::.|.:|.| :.|.|
Human    96 AACQLGIPPTQVVRR-AQDFVYHLHCFACVVCKRQLATGDEFYLMEDSRLVC-KADYE------- 151

  Fly   399 AAAQHCGFVGLDEEDLLRPRDGRRGPKRPRTILTSQQRKQFKASFDQSPKPCRKVREALAKDTGL 463
                           ..:.|:.....|||||.:|::|.:..|::::.||||.|.|||.|:.:|||
Human   152 ---------------TAKQREAEATAKRPRTTITAKQLETLKSAYNTSPKPARHVREQLSSETGL 201

  Fly   464 SVRVVQVWFQNQRAKMKKIQRKA-KQNGG--------SGGGSGSGRGTGNSSATDDKDTNDKEDK 519
            .:|||||||||:|||.|::::.| :|..|        |.|||.|.:.:.......|.:.:..::.
Human   202 DMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRGGSKSDKDSVQEGQDSDAEVSFPDEP 266

  Fly   520 CVKQ---------ELG------GDSSGYL-------GGLDSTFASQPLNPNLPFSPDDYPA 558
            .:.:         .||      |..||.|       |||......:.|.|..|:.....||
Human   267 SLAEMGPANGLYGSLGEPTQALGRPSGALGNFSLEHGGLAGPEQYRELRPGSPYGVPPSPA 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	22/51 (43%)
		LIM	333..388	CDD:413332	21/55 (38%)
		Homeodomain	425..481	CDD:459649	32/55 (58%)
LHX3	NP_055379.1	LIM1_Lhx3b	33..87	CDD:188851	22/53 (42%)
		LIM2_Lhx3_Lhx4	95..150	CDD:188762	20/56 (36%)
		Homeodomain	163..219	CDD:459649	32/55 (58%)