Protein Alignment Lmx1a and Scr

DIOPT Version :10

• Sequence 1: NP_729801.1
• Gene: Lmx1a / 39406
• FlyBaseID: FBgn0052105
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 711
• Identity: 143/711 - (20%)
• Similarity: 197/711 - (27%)
• Gaps: 321/711 - (45%)

  Fly     8 PTNLNPVGGSLYSLQQNHGGARFLDNPNPGSMTASSGNS-------------------------- 46
            |..:||        ||||.||   .|.:.|.....:|.|
  Fly    22 PQQMNP--------QQNHPGA---GNSSAGGSGGGAGGSGGVVPSGGTNGGQGSAGAATPGANDY 75

  Fly    47 -----LHLSNSNNNLP-------TSISGNNSPTAT--------ASLTGQHQQHQQQQH------- 84
                 .:..|...|.|       .:..|..:|...        ..|..|.||.|||||
  Fly    76 FPAAAAYTPNLYPNTPQAHYANQAAYGGQGNPDMVDYTQLQPQRLLLQQQQQQQQQQHAHAAAAV 140

  Fly    85 --QQQQQHPHQQH-QQHQQQHAASTTPVPINSCPTPTGHSPLSSSSSNSNHNNNNNNNNGGSSSN 146
              |||||...||| ||.|||..|:.:....|...||.|......|.||:|:|:.|:|||   :|.
  Fly   141 AAQQQQQLAQQQHPQQQQQQQQANISCKYANDPVTPGGSGGGGVSGSNNNNNSANSNNN---NSQ 202

  Fly   147 NLHSACNTLTAAAVAAASAAAVAAPSPAGTSVATSQLGGAVAAAIAAAAAAAAAATTPTSTGPAA 211
            :|.|..:      ::....:...:||....|||.|...|.:..::|||||||..
  Fly   203 SLASPQD------LSTRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGL----------- 250

  Fly   212 TGSGNANGSGNGNGNGNGNGNGNGNGNGGGAATASAAAASKLSADCSGRTEVGHIKCEKNFELCE 276
                |.|.||:|...|.||.|...:..|||              |....::.|:   |.......
  Fly   251 ----NNNHSGSGVSGGPGNVNVPMHSPGGG--------------DSDSESDSGN---EAGSSQNS 294

  Fly   277 GCGQKIHDRFLMNVGDANWHEQCLACCYCGMQLHHTCYVRNSKLYCKMDYDRLFGVKCSSCCHAI 341
            |.|:|                                  ...::|..|
  Fly   295 GNGKK----------------------------------NPPQIYPWM----------------- 308

  Fly   342 LPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFMLRDGQLFCYRHDLEKEMFLAAAAAQHCGF 406
                                                              |.:.|..:.....|
  Fly   309 --------------------------------------------------KRVHLGTSTVNANG- 322

  Fly   407 VGLDEEDLLRPRDGRRGPKRPRTILTSQQRKQFKASFDQSPKPCRKVREALAKDTGLSVRVVQVW 471
                            ..||.||..|..|..:.:..|..:....|:.|..:|....|:.|.:::|
  Fly   323 ----------------ETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIW 371

  Fly   472 FQNQRAKMKKIQRKAKQN----------------------------------------------- 489
            |||:|.|.||..:.|..|
  Fly   372 FQNRRMKWKKEHKMASMNIVPYHMGPYGHPYHQFDIHPSQFAHLSAXDAWHFSGTGXRLNQLYQE 436

  Fly   490 -------------------GGSGGGS-GSGRGTGNSSATDDKDTNDKEDKCVKQELGGDSSGYLG 534
                               |..|||| |.|.|.|...:.                ..|.|:|  .
  Fly   437 PYQTAAAASAASGYQSQDGGPIGGGSVGVGGGAGGPGSL----------------ANGGSNG--S 483

  Fly   535 GLDSTFASQPLNPNLPFSPD--DYPANSNDSFCSSDLSLDGSNFDQLDDDADSLSLNNLEL 593
            |.:|.|||...:..   :||  .||..     . |.:.:...:..|.|:..|.....:|:|
  Fly   484 GPNSLFASAASSSQ---APDCIKYPQE-----FXSQVIIRQQHQQQQDNSMDRNQERDLKL 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	5/51 (10%)
		LIM	333..388	CDD:413332	0/54 (0%)
		Homeodomain	425..481	CDD:459649	18/55 (33%)
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	18/55 (33%)