Protein Alignment Lmx1a and lhx1b

DIOPT Version :10

• Sequence 1: NP_729801.1
• Gene: Lmx1a / 39406
• FlyBaseID: FBgn0052105
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_571282.1
• Gene: lhx1b / 30454
• ZFINID: ZDB-GENE-980526-116
• Length: 402
• Species: Danio rerio
• Alignment Length: 414
• Identity: 122/414 - (29%)
• Similarity: 169/414 - (40%)
• Gaps: 108/414 - (26%)

  Fly   275 CEGCGQKIHDRFLMNVGDANWHEQCLACCYCGMQLHHTCYVRNSKLYCKMDYDRLFGVKCSSCCH 339
            |.||.:.|.||||::|.|..||.:|:.||.|...|...|:.|..:||||.|:.|.:|.||..|..
Zfish     4 CAGCERPILDRFLLSVLDRAWHAKCVQCCDCKCSLTDRCFSREGRLYCKNDFFRRYGTKCGGCAQ 68

  Fly   340 AILPQELVMRPIPNFVFHLPCFVCYACRLPLQKGEQFMLRDGQLF-CYRHDLEKEMFLAAAAAQH 403
            .|.|.:|| |...:.||||.||.|..|...|..||:..:.|...| |      ||.:|..:..:.
Zfish    69 GISPSDLV-RKARSKVFHLNCFTCIMCNKQLSTGEELYILDEYKFVC------KEDYLNNSNGKD 126

  Fly   404 CGFVGLD--EEDLLRP---------RDGRRGP------------------KR--PRTILTSQQRK 437
            ...:.:.  .:..|.|         :|...||                  ||  |||.:.::|.:
Zfish   127 TNLLSITTCSDPSLSPESQDPQDDYKDSESGPMSDKETCNNENDEQNLGGKRRGPRTTIKAKQLE 191

  Fly   438 QFKASFDQSPKPCRKVREALAKDTGLSVRVVQVWFQNQRAKMKKIQRKAKQNGGSGG-------- 494
            ..||:|..:|||.|.:||.||::|||::||:||||||:|:|    :|:.||....|.
Zfish   192 TLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSK----ERRMKQLSALGARRHMFFRS 252

  Fly   495 -----------GSGSGRGTGNSSATDDKDTNDKEDKCVKQELGGDSSGYLGGLDSTFASQPLNP- 547
                       ..|.....|:.|...|          .:.|..|..|.|........:||...|
Zfish   253 PRRMRALGDRMEPGELMANGHFSFYGD----------YQSEYYGPGSNYDYFPQGPPSSQAHTPG 307

  Fly   548 NLPFSPDDYPAN---------------SNDSFCSSDL-----------------SLDGSNFDQLD 580
            :|.|.|...||.               |||:.|.|::                 |:...:.|..|
Zfish   308 DLGFMPSSGPAGTPLGNMDPHHGAHHPSNDTQCFSEMISHHPGDSPSPEPSAPASIHSISTDMCD 372

  Fly   581 DDADSLSLNNLELQSTSSSGNQHS 604
            ......|||:|   |.:...||.|
Zfish   373 STPPFTSLNSL---SANGYSNQLS 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lmx1a	NP_729801.1	LIM1_Lmx1b	275..327	CDD:188757	24/51 (47%)
		LIM	333..388	CDD:413332	22/55 (40%)
		Homeodomain	425..481	CDD:459649	30/57 (53%)
lhx1b	NP_571282.1	LIM1_Lhx1_Lhx5	4..55	CDD:188753	23/50 (46%)
		LIM2_Lhx1_Lhx5	63..118	CDD:188761	23/61 (38%)
		Homeodomain	179..235	CDD:459649	28/59 (47%)