Protein Alignment CAH2 and CA8

DIOPT Version :10

• Sequence 1: NP_648555.1
• Gene: CAH2 / 39390
• FlyBaseID: FBgn0027843
• Length: 335
• Species: Drosophila melanogaster
• Sequence 2: NP_001399060.1
• Gene: CA8 / 767
• HGNCID: 1382
• Length: 306
• Species: Homo sapiens
• Alignment Length: 297
• Identity: 100/297 - (33%)
• Similarity: 146/297 - (49%)
• Gaps: 64/297 - (21%)

  Fly    27 DFGYEGRHGPEHWSEDYARCSGKHQSPINIDQVSAVEKKFPKLEFFNFKVVPD-----NLQMTNN 86
            ::|||  .|.| |...:...:|::|||||::...|  :..|.|  .:.::.|:     :.::||:
Human    28 EWGYE--EGVE-WGLVFPDANGEYQSPINLNSREA--RYDPSL--LDVRLSPNYVVCRDCEVTND 85

  Fly    87 GHTVLVKMSYNEDEIPSVRGGPLAEKTPLGYQFE--QFHFHWGENDTIGSEDLINNRAYPAELHV 149
            |||:.|.:....    .:.||||    |.|::||  :..||||..:..|||..:|.:|:|.|||:
Human    86 GHTIQVILKSKS----VLSGGPL----PQGHEFELYEVRFHWGRENQRGSEHTVNFKAFPMELHL 142

  Fly   150 VLRNLE-YPDFASALDKDHGIAVMAFFFQVGDKSTGGYEGFTNLLSQIDRKGKS-------VNMT 206
            :..|.. :.....|:.|.||||::|.|.|:| |...|.:..|.:|..|..||||       .|..
Human   143 IHWNSTLFGSIDEAVGKPHGIAIIALFVQIG-KEHVGLKAVTEILQDIQYKGKSKTIPCFNPNTL 206

  Fly   207 NPLPLGEYISKSVESYFSYTGSLTTPPCSEEVTWIDFTTPIDITEKQ----------------LN 255
            .|.||       :..|:.|.||||.|||||.||||.|..|:.|::.|                :.
Human   207 LPDPL-------LRDYWVYEGSLTIPPCSEGVTWILFRYPLTISQLQVWRMESGRKVGMPVISIE 264

  Fly   256 AFRLLTAN----------DDHLKNNFRPIQPLNDRTL 282
            .||.|..:          |..|.:||||.|||:||.:
Human   265 EFRRLRTHVKGAELVEGCDGILGDNFRPTQPLSDRVI 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH2	NP_648555.1	Carb_anhydrase	34..286	CDD:459707	97/290 (33%)
CA8	NP_001399060.1	alpha_CARP_VIII	35..305	CDD:239394	96/288 (33%)