Protein Alignment CAH2 and CA5A

DIOPT Version :10

• Sequence 1: NP_648555.1
• Gene: CAH2 / 39390
• FlyBaseID: FBgn0027843
• Length: 335
• Species: Drosophila melanogaster
• Sequence 2: NP_001730.1
• Gene: CA5A / 763
• HGNCID: 1377
• Length: 305
• Species: Homo sapiens
• Alignment Length: 262
• Identity: 82/262 - (31%)
• Similarity: 132/262 - (50%)
• Gaps: 31/262 - (11%)

  Fly    39 WSEDYARCSGKHQSPINI---DQVSAVEKKFPKLEFFNFKVVPDNLQMTNNGHTVLVKMSYNEDE 100
            |:...:...|..||||||   |.|...:.|..::.:    .....|.:.|.|:...|:.. :..|
Human    52 WTVPVSVPGGTRQSPINIQWRDSVYDPQLKPLRVSY----EAASCLYIWNTGYLFQVEFD-DATE 111

  Fly   101 IPSVRGGPLAEKTPLGYQFEQFHFHWGENDTIGSEDLINNRAYPAELHVVLRN-LEYPDFASALD 164
            ...:.||||...    |:.:|||||||..:..|||..::..|||||||:|..| ::|.::..|:.
Human   112 ASGISGGPLENH----YRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVV 172

  Fly   165 KDHGIAVMAFFFQVGDKSTGGYEGFTNLLSQIDRKGKSVNM-----TNPLPLGEYISKSVESYFS 224
            .::|:||:..|.::|.... ..:...::|.:|..|.....|     :..||       :...|::
Human   173 GENGLAVIGVFLKLGAHHQ-TLQRLVDILPEIKHKDARAAMRPFDPSTLLP-------TCWDYWT 229

  Fly   225 YTGSLTTPPCSEEVTWIDFTTPIDITEKQLNAFRLLT-----ANDDHLKNNFRPIQPLNDRTLYK 284
            |.|||||||.:|.||||....|:::...||:|||.|.     ..:..:.||:||:|||.:|.::.
Human   230 YAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWA 294

  Fly   285 NY 286
            ::
Human   295 SF 296

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH2	NP_648555.1	Carb_anhydrase	34..286	CDD:459707	82/260 (32%)
CA5A	NP_001730.1	alpha_CA_V	61..296	CDD:239392	81/251 (32%)