DRSC/TRiP Functional Genomics Resources

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Protein Alignment CAH2 and PTPRG

DIOPT Version :10

Sequence 1:NP_648555.1 Gene:CAH2 / 39390 FlyBaseID:FBgn0027843 Length:335 Species:Drosophila melanogaster
Sequence 2:XP_016862450.1 Gene:PTPRG / 5793 HGNCID:9671 Length:1485 Species:Homo sapiens


Alignment Length:314 Identity:101/314 - (32%)
Similarity:142/314 - (45%) Gaps:65/314 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 FGYEGRHGPEHWSEDYARCSGKHQSPINI-DQVSAVEKKFPKLEFFNFKVVPDN-LQMTNNGHTV 90
            :.|.|.:|||||......|.|:|||||:| ||.:.|.:::.:|:...|.....| ..|.|.|.||
Human    60 WAYSGAYGPEHWVTSSVSCGGRHQSPIDILDQYARVGEEYQELQLDGFDNESSNKTWMKNTGKTV 124

  Fly    91 --LVKMSYNEDEIPSVRGGPLAEKTPLGYQFEQFHFHWG-ENDTIGSEDLINNRAYPAE------ 146
              |:|..|      .|.|..|    |..::.|:..|||| .|.:.|||..||.|.:|.|      
Human   125 AILLKDDY------FVSGAGL----PGRFKAEKVEFHWGHSNGSAGSEHSINGRRFPVEAEDARG 179

  Fly   147 ----------LHVVLRNL-------------------------EYPDFASALDKDHGIAVMAFFF 176
                      :..:|..|                         ::..|.:|:.::..|..||.||
Human   180 GDIMLMLSQGMRFILLGLKKEQFEERKSWTTYQSMQIFFYNPDDFDSFQTAISENRIIGAMAIFF 244

  Fly   177 QVGDKSTGGYEGFTNLLSQIDRKGKSVNMTNPLPLGEYISKSVESYFSYTGSLTTPPCSEEVTWI 241
            ||..:.....:...:.|..:....|. ...:|..|.:.:..|:.||:.||||||||||||.|.||
Human   245 QVSPRDNSALDPIIHGLKGVVHHEKE-TFLDPFVLRDLLPASLGSYYRYTGSLTTPPCSEIVEWI 308

  Fly   242 DFTTPIDITEKQLNAFRLL--TANDDH------LKNNFRPIQPLNDRTLYKNYI 287
            .|..|:.|:..||.||..:  |...||      |:|||||.|.|:||.:.|:.:
Human   309 VFRRPVPISYHQLEAFYSIFTTEQQDHVKSVEYLRNNFRPQQRLHDRVVSKSAV 362

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CAH2NP_648555.1 Carb_anhydrase 34..286 CDD:459707 99/305 (32%)
PTPRGXP_016862450.1 alpha_CARP_receptor_like 67..359 CDD:239396 98/302 (32%)
FN3 388..478 CDD:238020
PHA03169 <584..>742 CDD:223003
R-PTPc-G-1 888..1161 CDD:350505
R-PTP-G-2 1245..1449 CDD:350508
Blue background indicates that the domain is not in the aligned region.

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