Protein Alignment CAH2 and CA13

DIOPT Version :10

• Sequence 1: NP_648555.1
• Gene: CAH2 / 39390
• FlyBaseID: FBgn0027843
• Length: 335
• Species: Drosophila melanogaster
• Sequence 2: NP_940986.1
• Gene: CA13 / 377677
• HGNCID: 14914
• Length: 262
• Species: Homo sapiens
• Alignment Length: 268
• Identity: 97/268 - (36%)
• Similarity: 141/268 - (52%)
• Gaps: 21/268 - (7%)

  Fly    28 FGYEGRHGPEHWSEDYARCSGKHQSPINIDQVSAVEKKF-PKLEFFNFKVVPDNLQ-MTNNGHTV 90
            :||...:||.||.|.:....|..||||   ::...|.|: ..|...:.|..|.:.: ::|:||:
Human     6 WGYREHNGPIHWKEFFPIADGDQQSPI---EIKTKEVKYDSSLRPLSIKYDPSSAKIISNSGHS- 66

  Fly    91 LVKMSYNEDEIPSV-RGGPLAEKTPLGYQFEQFHFHWGENDTIGSEDLINNRAYPAELHVVLRNL 154
             ..:.:::.|..|| |||||..    .|:..|.|.|||..|..|||.:::..:|.||||||..|.
Human    67 -FNVDFDDTENKSVLRGGPLTG----SYRLRQVHLHWGSADDHGSEHIVDGVSYAAELHVVHWNS 126

  Fly   155 E-YPDFASALDKDHGIAVMAFFFQVGDKSTGGYEGFTNLLSQIDRKGKSVNMTNPLPLGEYISKS 218
            : ||.|..|..:..|:||:..|.|:|:.:: ..:..|:.|..|..|||....|| ..|...:..|
Human   127 DKYPSFVEAAHEPDGLAVLGVFLQIGEPNS-QLQKITDTLDSIKEKGKQTRFTN-FDLLSLLPPS 189

  Fly   219 VESYFSYTGSLTTPPCSEEVTWIDFTTPIDITEKQLNAFR--LLTANDD---HLKNNFRPIQPLN 278
            .: |::|.||||.||..|.||||....||:|:.:||..||  |.||..:   .|.:|.||.|||.
Human   190 WD-YWTYPGSLTVPPLLESVTWIVLKQPINISSQQLAKFRSLLCTAEGEAAAFLVSNHRPPQPLK 253

  Fly   279 DRTLYKNY 286
            .|.:..::
Human   254 GRKVRASF 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH2	NP_648555.1	Carb_anhydrase	34..286	CDD:459707	95/260 (37%)
CA13	NP_940986.1	alpha_CA_I_II_III_XIII	2..261	CDD:239393	97/266 (36%)