DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycA and ccna2

DIOPT Version :9

Sequence 1:	NP_524030.2	Gene:	CycA / 39340	FlyBaseID:	FBgn0000404	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_694481.1	Gene:	ccna2 / 192295	ZFINID:	ZDB-GENE-020418-1	Length:	428	Species:	Danio rerio

Alignment Length:	479	Identity:	171/479 - (35%)
Similarity:	251/479 - (52%)	Gaps:	95/479 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IH-QDMSNKENPGIKIPAGVKNTKQPLAVIGGKAEKNALAPRANFAVLNGNNNVPRPAGKVQVFR 69
            :| .|:.|:||              .|:.:.|.|.||.:..|.|   :|.|   |:.|....|..
Zfish     8 VHDSDIHNQEN--------------MLSRLRGAAAKNRVENREN---VNPN---PKAANNRTVLG 52

  Fly    70 DVRN---------------------LNVDENV-EYGAKKSNVVPVVEQFKTFSVYEDNND---TQ 109
            ::.|                     ...:||. .:|.:.||..|.     .|.::.|..|   ::
Zfish    53 ELENSQRRQLGLRGAKQGSGPQIIACKPEENARSFGERPSNRQPA-----AFQIHVDEPDGACSK 112

  Fly   110 VAPSGKSLASLVDKENHDVKFGAGQKELVDYDLDSTPM----SVTDVQSPM-SVDRSILGVIQS- 168
            .||..:|                        .:|.:|:    :||.::.|: ::|..:.....|
Zfish   113 KAPLQRS------------------------TMDCSPLTLNPTVTRLRQPLATIDLPLEASFDSP 153

  Fly   169 SDISVGTETGVSPTGRVKELPPRNDRQRFLEVVQYQMDILEYFRESEKKHRPKPLYMRRQKDISH 233
            .|:|| .:....||             ...||..|..:|..:.||.|.|.:||..|||:|.||::
Zfish   154 MDMSV-IDCEERPT-------------NVNEVSDYAAEIHTHLREMEVKSKPKAGYMRKQPDITN 204

  Fly   234 NMRSILIDWLVEVSEEYKLDTETLYLSVFYLDRFLSQMAVVRSKLQLVGTAAMYIAAKYEEIYPP 298
            :||:||:||||||.|||||..|||||:|.|:|||||.|:|:|.||||||||||.:|:|:||||||
Zfish   205 SMRAILVDWLVEVGEEYKLQNETLYLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPP 269

  Fly   299 EVGEFVFLTDDSYTKAQVLRMEQVILKILSFDLCTPTAYVFINTYAVLCDMPEKLKYMTLYISEL 363
            ||.|||::|||:|||.||||||.::|.:|||||..||...|:..|.:...:..|::.:::::.||
Zfish   270 EVAEFVYITDDTYTKKQVLRMEHLVLTVLSFDLAAPTINQFLTQYFLHQPVSSKVESLSMFLGEL 334

  Fly   364 SLMEGETYLQYLPSLMSSASVALARHILGMEMWTPRLEEITTYKLEDLKTVVLHLCHTHKTAKEL 428
            ||::.:.:|:||||.|::|:..||.|.|....|:..|.::|.|.||||...|..|..|:..|.:.
Zfish   335 SLIDCDPFLKYLPSQMAAAAFILANHTLASGSWSKSLVDLTGYSLEDLLPCVQDLHQTYLAASQH 399

  Fly   429 NTQAMREKYNRDTYKKVAMMESVE 452
            ..||:||||....|.:|:::|..|
Zfish   400 AQQAVREKYKGSKYHEVSLIEPPE 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycA	NP_524030.2	Cyclin_N	206..332	CDD:278560	83/125 (66%)
CycA	NP_524030.2	Cyclin_C	334..450	CDD:281044	40/115 (35%)
ccna2	NP_694481.1	Cyclin_N2	33..157	CDD:293109	28/158 (18%)
		Cyclin_N	177..303	CDD:278560	83/125 (66%)
		Cyclin_C	305..422	CDD:281044	41/116 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	180	1.000	Domainoid score	I3458
eggNOG	1	0.900	-	-		E1_COG5024
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55562
Inparanoid	1	1.050	245	1.000	Inparanoid score	I3265
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D520533at33208
OrthoFinder	1	1.000	-	-		FOG0000121
OrthoInspector	1	1.000	-	-		otm26218
orthoMCL	1	0.900	-	-		OOG6_100199
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X94
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.830