DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6071 and AgaP_AGAP004808

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_554544.3	Gene:	AgaP_AGAP004808 / 3289852	VectorBaseID:	AGAP004808	Length:	867	Species:	Anopheles gambiae

Alignment Length:	945	Identity:	212/945 - (22%)
Similarity:	356/945 - (37%)	Gaps:	232/945 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LAESFVKPLRYNLTILTRLGSEDEQNQFEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWA 81
            :.||:|..|..|:        ..|...::|.|:|.:...|.||.|.|:||.
Mosquito    72 IPESYVLELSSNV--------HAEDFSYDGSVAIRVRVLQTTRSIVLHSLY-------------- 114

  Fly    82 SGRKIGALQIKRIIKKTSLIKIVIELP------------LRSGEIYTLNMLFSGNLDRSQQYGYF 134
              .|:..::::...:....|..|.|.|            |:.| ||.|.:||...| |....|::
Mosquito   115 --SKLVKVEVRNANQLNIPISTVEEDPALETLTIRTDHELQRG-IYQLTILFENTL-RDDFGGFY 175

  Fly   135 AGYYDKTPRVFYSA-TRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKE 198
            ...|:....|.||| |:.:|..|.|.|||:|:|..|..:.|::.........||||
Mosquito   176 RTSYNSGNEVRYSAVTQFQPVDARTAFPCYDEPGIRATFTISITSGVGTKVYSNMP--------- 231

  Fly   199 IENYVSTTFMG----------SPPLATQQVMWTLHQLEKVYSGPAAAGENITVWSRP-HLAEKLA 252
               ..|||..|          :|.:.|..|.:.:..        ..|...:::...| .:..:|.
Mosquito   232 ---IKSTTITGNGLKQTRFHTTPSMPTYLVAFAITD--------NFASTRLSLRGPPSSINMELI 285

  Fly   253 KVPEMTPNLFSKYETLFAYPLPKGADWGG-----------------KVDHVVLPR-YTEMYSGQG 299
            ..|.:|       :|...|    |.|.||                 |:|.:.:|. |.......|
Mosquito   286 APPTVT-------DTAQTY----GLDLGGQIIRTVEQYFNQSYDLPKLDQLAVPDFYFAAMENWG 339

  Fly   300 IMVYGE-----DIVDSGQNGLESLQETLAELVARQWNGLLVNLEDSDEEYVRNGI----NYYLS- 354
            :::|.|     |.:.|.....|::..|:......|:.|.|:......:..:..|.    .||||
Mosquito   340 LVIYEERYLLYDELTSTNRDKENVIATVVHEFVHQFLGNLLTPHWWSDLSLSEGFATFYEYYLSS 404

  Fly   355 -VQVMAMDKEAYNTTHLSKTRLDVLYHDSLAKVKSIA------TDVKESGHQKLRKKKMCLLIHM 412
             |:.....||.:....|.    ..|..|....|:.|:      ||: |.....:..:|...:..|
Mosquito   405 MVEPSIRFKEKFTVEALQ----PALLFDCDINVRPISYSVETRTDI-ERMFDIISYQKGGSIFRM 464

  Fly   413 LKVALGDKLFLKGLQEFFKRYANSSASSKELWEEFQRGARRSHQLPTGVSLPTVMESWMKQPGFP 477
            ...|||:..|:||::.:.......|.:...|:|..|..|.....||..:.:.|:|..|:.|.|:|
Mosquito   465 FHYALGELTFVKGIRRYISVNKGRSVTPDILFESLQVAASEDAVLPLSLDVGTIMRPWIFQSGYP 529

  Fly   478 LLTVQRDDAKQIVTITQSRYYQKYLDNSSNDCWWVPVAYIVR---NLTLPQVEWLGCQKNSRDIL 539
            ::||...:.:  :|..|..:..:....:|:..||:|:.|.|.   .....|..|:. |..|:..|
Mosquito   530 VVTVTLSNGE--LTFMQEHFLYRGSVVTSDRTWWIPITYHVHQSVGTVQSQQFWMP-QGTSQVSL 591

  Fly   540 ELSHIANPEDWLLINVDAAVPLRVFYDSYNL--QLISEALRQDFTQIPELSRIQLVDDALSLSWS 602
            |...:.  :.::::|.......||.||. ||  :||:: |..|.:.:..:||.||:||...|.:|
Mosquito   592 EQGDLM--DGFIVVNPQQTGYYRVNYDE-NLWIRLIAK-LSSDPSIVSPISRGQLLDDCFKLYYS 652

  Fly   603 GRLPYNVTLNVISYLSNETSVLVWETALL--NLEKLQS---IMRMTTGFRIFKLYMQKLIEPAFK 662
            ||:..|:..::::|..||...:.|..|..  ||..||.   :.||  .|..|..::..|....|
Mosquito   653 GRVGSNIIYSLLTYAENEIDAIPWTVAFANDNLGVLQGALVVERM--AFEAFSRFVTGLTANVF- 714

  Fly   663 TTLNSLSTKARTGSEIPINTKSPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESS 727
               |::...|     :|                                               |
Mosquito   715 ---NAVGFDA-----LP-----------------------------------------------S 724

  Fly   728 DTTESPDTTKSDLSLSAILYRLACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIR 792
            |..|:.       .|.:.:...:|:....||.|:|..|.  ..|....:.:|..::..|.|.|..
Mosquito   725 DEHETQ-------QLRSAVIEWSCRSGSSECRTEALARM--LNDLNGLTPLPMYLKYSVYCGGAT 780

  Fly   793 ----NGLEVHWIMVRDMFFESEND-KERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMT--- 849
                :.|:..|..:     :|.|| .:|..::.:|:|:..    ::.|...|||     ..|
Mosquito   781 IASPDVLQTLWASL-----QSVNDYGQRLNVIEALACSES----EQFLDDFLDS-----VFTNPI 831

  Fly   850 ----ASLLSAVL-RSPLGYYVGKQFLIDHSKEILR 879
                |::|.||. :|..||....:::..::.:|::
Mosquito   832 AGEWANILRAVYQKSAAGYEAYNRWIARNALQIVQ 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	116/510 (23%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	76/349 (22%)
AgaP_AGAP004808	XP_554544.3	Peptidase_M1	66..458	CDD:279741	99/447 (22%)
		M1_APN_2	74..529	CDD:189008	119/516 (23%)
		ERAP1_C	601..867	CDD:288671	76/349 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920