DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6071 and AgaP_AGAP013188

DIOPT Version :9

Sequence 1:	NP_648488.1	Gene:	CG6071 / 39308	FlyBaseID:	FBgn0036186	Length:	962	Species:	Drosophila melanogaster
Sequence 2:	XP_003436573.1	Gene:	AgaP_AGAP013188 / 11175889	VectorBaseID:	AGAP013188	Length:	935	Species:	Anopheles gambiae

Alignment Length:	989	Identity:	198/989 - (20%)
Similarity:	366/989 - (37%)	Gaps:	213/989 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VKPLRYNLTILTRLGSEDEQNQ--FEGIVSIDIEATQPTRVIYLNSLNITISRQRTWIYRWASGR 84
            |.|..|::.|...|..|..:.|  |:|...|.: :||..     |.:.|.:...|..|..|:..|
Mosquito    51 VWPTHYDIEIKPYLEQEGNKAQFTFDGSAKITV-STQKQ-----NVMQIKLHMARMDISAWSVTR 109

  Fly    85 KIGALQIKRI----IKKTSLIKIVIELPLRSGEIYTLNMLFSGNLDRSQQYGYFAGYY-DKTPRV 144
            |.....|..:    .::|.::.:.:...|::...|.|:..:.||:| ...:|::..|| :...:|
Mosquito   110 KSDNTIIPTLPQTYDQETQILTLPLSSALQANVEYVLSFTYVGNMD-DDMHGFYRSYYWEDGVKV 173

  Fly   145 FYSATRLEPDYAHTVFPCFDDPRFRTPYNITLVHDRKYVALSNMPPVEEKPYKEIENYVSTTFMG 209
            :..:|:.:..:|...|||||:|||:..:.:.:.|..:|...|| ..:......|:...: |||..
Mosquito   174 WMGSTQFQQTHARRAFPCFDEPRFKATFQLKINHKTQYNVYSN-TAIVGTAVAEVGRSL-TTFGV 236

  Fly   210 SPPLATQQVMWTL--HQLEKVYSGPAAAGENITVWSRPHLAEKLAKVPEMTPNLFSKYETLFAYP 272
            :|.:::..:.:.:  :|:..        .:.:.:.:||....:.....::...|....|....||
Mosquito   237 TPSMSSYLIAFIVAPYQIND--------RDGMGILARPQAQNQTQYSLDVGIKLLKALEEWIDYP 293

  Fly   273 LPKGADWGGKVDHVVLPRYTEMY------------SGQGIMVYGEDIVDSGQNGLESLQE----- 320
                        :..:...|.||            ...|::.|.|..:....:...|:|:
Mosquito   294 ------------YASVAGMTRMYMAAVPDFSAGAMENWGLLTYRETNILYRSDDSTSMQQHRIAA 346

  Fly   321 TLAELVARQWNGLLVNLEDSDEEYVRNGINYYLSVQVMAMDKEAYNTTH--LSKTRLDVLYHDSL 383
            .::..:|.||.|.||..|..|..::..|...|......|:.:..::..|  :.:....|:..|||
Mosquito   347 VISHEIAHQWFGDLVTCEWWDVTWLNEGFARYYQYYGTALVETEWDLDHQFVVEQLQGVMQMDSL 411

  Fly   384 AK----VKSIATDVKESG-HQKLRKKKMCLLIHMLKVALGDKLFLKGLQEFFKRYANSSASSKEL 443
            ..    ...:.|..:.|| ...:...|..:::.|::..|..:.|...|:.:.|..|..:...::|
Mosquito   412 RSTHPMTHPVYTQAQASGIFDNISYNKGAVMLRMMEHYLTTETFKTALRAYIKDRAFKTTRPEDL 476

  Fly   444 WEEFQR---GARRSHQLPTGVSLPTVMESWMKQPGFPLLTVQRDDAKQIVTITQSRYYQKYLDNS 505
            :....|   .||            :.||.|..|||:||:||...|..  .||||.|:.....|::
Mosquito   477 FSALNRYDPNAR------------SYMEPWTIQPGYPLVTVTSHDTG--FTITQKRFLVNEPDHN 527

  Fly   506 SNDCWWVPVAYIVR----NLTLP--------QVEWLGCQKNSRDILELSHIANPEDWLLINVDAA 558
            ....|.:|:.:..:    ::|.|        ::...|              |:..::.::|....
Mosquito   528 EQTAWPLPITFATKASEFSITRPAFYTGMTFEIPMQG--------------ASDVEYFILNNQQV 578

  Fly   559 VPLRVFYDSYNLQLISEALRQD-FTQIPELSRIQLVDDALSLSWSGRLPYNVTLNVISYLSNETS 622
            ...||.||:.....||:||..: |..|..|:|.|:|||..:|:....:||...|.::.||..||.
Mosquito   579 GYYRVNYDAILWGKISKALHSEGFGGIHVLNRAQIVDDLFNLARGDVVPYGTALEILEYLKEETE 643

  Fly   623 VLVWETALLNLEKLQSIMRMTTGFRIF----KLYMQKLIEPAFKTTLNSLSTKARTGSEIPINTK 683
            ...|..|:..|..|..        ||.    ||:...::: .|....:.:..:|.|.:|..|.|
Mosquito   644 YAPWLAAVNGLTTLSR--------RIHADDEKLFTAHILD-IFSKAYDIVKFQAPTATERRIFT- 698

  Fly   684 SPVTTESSGTTESPDTTESPDTAESPDTTESSNTTESPDTTESSDTTESPDTTKSDLSLSAILYR 748
                                                                     .:...:.:
Mosquito   699 ---------------------------------------------------------YMRQNVLQ 706

  Fly   749 LACQFEIKECLTDAQQRFQAAMDQKSSSSIPEEIREIVLCRGIRNGLEVHWIMVRDMFFESENDK 813
            .||.:..:||...|...|. ...|..|..:..::|::|.|.|||.|....:..:.:.:..:....
Mosquito   707 WACNYGHEECSKAAVAEFH-RYHQNPSVKVHPDLRQVVYCEGIRKGSTEEFEFLWNQYLTTNVAT 770

  Fly   814 ERSILLNSLSCTTEYWAMQKLLSWALDSKKVPRTMTASLLSAVLRS-----PLGYYVGKQFLIDH 873
            |:.::|..|.|              :.|.::...|...:.|..:||     ...|.:...:.:.|
Mosquito   771 EQILILQGLGC--------------VSSSELITDMLNGIASPHVRSQDKNNAFTYVINNPYTLPH 821

  Fly   874 SKEILRSKDVKLILTPFINAMSTKAEF----SALNDHLHRNLPSSMVSGLSSTLESGLDRVNWRN 934
            ....|:....        |..::...:    ||.|:.|.|....|....:|:.:||   ..|...
Mosquito   822 VSRYLQQNHA--------NWAASHGSYTNVASAFNNVLARLKSDSERDAISAFIES---NKNILG 875

  Fly   935 NLYFDLLKA-IRDF 947
            ...:|.:|: :.|:
Mosquito   876 QAAYDSIKSGLEDY 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6071	NP_648488.1	GluZincin	25..477	CDD:301352	99/487 (20%)
CG6071	NP_648488.1	ERAP1_C	551..929	CDD:288671	76/391 (19%)
AgaP_AGAP013188	XP_003436573.1	Peptidase_M1	46..439	CDD:279741	84/416 (20%)
		M1_APN_2	54..501	CDD:189008	99/487 (20%)
		ERAP1_C	571..888	CDD:288671	79/409 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0308
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920