Protein Alignment Plod and PLOD2

DIOPT Version :10

• Sequence 1: NP_648451.1
• Gene: Plod / 39265
• FlyBaseID: FBgn0036147
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_891988.1
• Gene: PLOD2 / 5352
• HGNCID: 9082
• Length: 758
• Species: Homo sapiens
• Alignment Length: 761
• Identity: 323/761 - (42%)
• Similarity: 480/761 - (63%)
• Gaps: 61/761 - (8%)

  Fly    10 LLLLAVTSQGDAESNWN---------------DKIKVFTVATEPTDGYTRYIRSARVYDIEVTTL 59
            |||||:...     .||               ||:.|.||||:.:||:.|:::||:.::..|..|
Human    10 LLLLALVLH-----PWNPCLGADSEKPSSIPTDKLLVITVATKESDGFHRFMQSAKYFNYTVKVL 69

  Fly    60 GLGEEWKGGD-MQKPGGGFKLNLLREAIAPYKNEPETIILFTDSYDVIITTTLDEIFEKFKESGA 123
            |.||||:||| :...|||.|:.|::|.:..|.::.:.:::||:.:|||.....:|:.:||:::..
Human    70 GQGEEWRGGDGINSIGGGQKVRLMKEVMEHYADQDDLVVMFTECFDVIFAGGPEEVLKKFQKANH 134

  Fly   124 KILFSAEKYCWPDKSLANDYPEVE-GKASRFLNSGAFIGYAPQVFALLVD-PIEDTADDQLYFTK 186
            |::|:|:...||||.||:.||.|. ||  |:||||.||||||.|..::.. .::|..||||::||
Human   135 KVVFAADGILWPDKRLADKYPVVHIGK--RYLNSGGFIGYAPYVNRIVQQWNLQDNDDDQLFYTK 197

  Fly   187 IFLDETKRAKLGLKLDVQSRLFQNLHGAKNDVKLKVDLESNQGVLQNVDFMTTPSIIHGNGLSKV 251
            :::|..||..:.:.||.:.::||.|:||.::|.||  .|:.:...:|..:.|.|..|:|||.:|:
Human   198 VYIDPLKREAINITLDHKCKIFQTLNGAVDEVVLK--FENGKARAKNTFYETLPVAINGNGPTKI 260

  Fly   252 DLNAYGNYLARTF---NGVCLLCQENLLDLEETNL-PVISLALMVTQPVPFFDQFLEGIESLNYP 312
            .||.:|||:..::   || |.||:.:.:||...:: |.:|:.:.:.||.||..:||:.:.:|:||
Human   261 LLNYFGNYVPNSWTQDNG-CTLCEFDTVDLSAVDVHPNVSIGVFIEQPTPFLPRFLDILLTLDYP 324

  Fly   313 KEKLHLLIYSNVAFHDDDIKSFVNKHAKEYATAKFALSTDELDERQGRQLALDKARLHQS-DYIF 376
            ||.|.|.|::...:|:.|||.|.:|...|..|.|.....:.|.:.:.|.:.:|..|..:. ||.|
Human   325 KEALKLFIHNKEVYHEKDIKVFFDKAKHEIKTIKIVGPEENLSQAEARNMGMDFCRQDEKCDYYF 389

  Fly   377 FVDADAHIDDGEVLRELLRLNKQFVAPIFSKHKELWSNFWGALSEGGYYARSHDYVDIVKRELIG 441
            .||||..:.:...|:.|:..|::.:||:.::|.:||||||||||..||||||.||||||:...:|
Human   390 SVDADVVLTNPRTLKILIEQNRKIIAPLVTRHGKLWSNFWGALSPDGYYARSEDYVDIVQGNRVG 454

  Fly   442 MFNVPHVTSIYLVK-KTAFDAIS----FKHKEFDPDMAMCESLRN-------------------- 481
            ::|||::.::||:| ||....::    |...:.|||||:|.:.|.
Human   455 VWNVPYMANVYLIKGKTLRSEMNERNYFVRDKLDPDMALCRNAREMTLQREKDSPTPETFQMLSP 519

  Fly   482 -AGIFMYASNLRIFGHLVNADDFNTTVTRPDFYTLFSNEIDWTEKYIHPNYSLQLNESNKIQQPC 545
             .|:|||.||...||.|::..::||:....|.:.:|.|.:||.||||:.:||....| |.::|||
Human   520 PKGVFMYISNRHEFGRLLSTANYNTSHYNNDLWQIFENPVDWKEKYINRDYSKIFTE-NIVEQPC 583

  Fly   546 PDVYWFQIVSDAFCDDLVAIMEAHNGWSDGSNNDNRLEGGYEAVPTRDIHMKQVGLERLYLKFLQ 610
            |||:||.|.|:..||:||..||.:..||.|.::|:|:.||||.|||.|||||||.||.::|.|::
Human   584 PDVFWFPIFSEKACDELVEEMEHYGKWSGGKHHDSRISGGYENVPTDDIHMKQVDLENVWLHFIR 648

  Fly   611 MFVRPLQERAFTGYFHNPPRALMNFMVRYRPDEQPSLRPHHDSSTYTINIAMNRAGIDYQGGGCR 675
            .|:.|:..:.|.||: ....||:||:|:|.|:.|.|||||||:||:|||||:|..|.|:|||||:
Human   649 EFIAPVTLKVFAGYY-TKGFALLNFVVKYSPERQRSLRPHHDASTFTINIALNNVGEDFQGGGCK 712

  Fly   676 FIRYNCSVTDTKKGWMLMHPGRLTHYHEGLLVTNGTRYIMISFIDP 721
            |:|||||:...:|||..||||||||.||||.|.||||||.:|||||
Human   713 FLRYNCSIESPRKGWSFMHPGRLTHLHEGLPVKNGTRYIAVSFIDP 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plod	NP_648451.1	GT_LH	27..257	CDD:459235	94/232 (41%)
		Glyco_tranf_GTA_type	303..>395	CDD:472172	31/92 (34%)
		P4Hc	555..719	CDD:214780	94/163 (58%)
PLOD2	NP_891988.1	GT_LH2	37..266	CDD:438559	94/232 (41%)
		P4Hc	593..756	CDD:214780	94/163 (58%)