Protein Alignment Plod and PLOD1

DIOPT Version :10

• Sequence 1: NP_648451.1
• Gene: Plod / 39265
• FlyBaseID: FBgn0036147
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001303249.1
• Gene: PLOD1 / 5351
• HGNCID: 9081
• Length: 774
• Species: Homo sapiens
• Alignment Length: 711
• Identity: 316/711 - (44%)
• Similarity: 460/711 - (64%)
• Gaps: 23/711 - (3%)

  Fly    26 NDKIKVFTVATEPTDGYTRYIRSARVYDIEVTTLGLGEEWKGGDMQKPGGGFKLNLLREAIAPYK 90
            :|.:.|.||||:.|:|:.|:.|||:.::.::..|||||:|........|||.|:.||::|:..:.
Human    72 SDNLLVLTVATKETEGFRRFKRSAQFFNYKIQALGLGEDWNVEKGTSAGGGQKVRLLKKALEKHA 136

  Fly    91 NEPETIILFTDSYDVIITTTLDEIFEKFKESGAKILFSAEKYCWPDKSLANDYPEV-EGKASRFL 154
            ::.:.:|||.|||||:..:...|:.:||:::.::::||||:..:||:.|...||.| :||  |||
Human   137 DKEDLVILFADSYDVLFASGPRELLKKFRQARSQVVFSAEELIYPDRRLETKYPVVSDGK--RFL 199

  Fly   155 NSGAFIGYAPQVFALLVD-PIEDTADDQLYFTKIFLDETKRAKLGLKLDVQSRLFQNLHGAKNDV 218
            .||.||||||.:..|:.: ..:|:..|||::||||||..||.::.:.||.:.|:||||.||.::|
Human   200 GSGGFIGYAPNLSKLVAEWEGQDSDSDQLFYTKIFLDPEKREQINITLDHRCRIFQNLDGALDEV 264

  Fly   219 KLKVDLESNQGVLQNVDFMTTPSIIHGNGLSKVDLNAYGNYLAR--TFNGVCLLCQENLLDLE-- 279
            .||.::...:.  :|:.:.|.|.:|||||.:|:.||..|||:.|  ||...|.:|.|.|..|:
Human   265 VLKFEMGHVRA--RNLAYDTLPVLIHGNGPTKLQLNYLGNYIPRFWTFETGCTVCDEGLRSLKGI 327

  Fly   280 -ETNLPVISLALMVTQPVPFFDQFLEGIESLNYPKEKLHLLIYSNVAFHDDDIKSFVNKHAKEYA 343
             :..||.:.:.:.:.||.||...|.:.:..|:||::.:.|.|:::...|...::.|:.:|..||.
Human   328 GDEALPTVLVGVFIEQPTPFVSLFFQRLLRLHYPQKHMRLFIHNHEQHHKAQVEEFLAQHGSEYQ 392

  Fly   344 TAKFALSTDELDERQGRQLALDKARLHQS-DYIFFVDADAHIDDGEVLRELLRLNKQFVAPIFSK 407
            :.|.......:.....|.:..|..|..:| .|.|.||||..:.:...||.|::.||..:||:.::
Human   393 SVKLVGPEVRMANADARNMGADLCRQDRSCTYYFSVDADVALTEPNSLRLLIQQNKNVIAPLMTR 457

  Fly   408 HKELWSNFWGALSEGGYYARSHDYVDIVKRELIGMFNVPHVTSIYLVKKTAF-----DAISFKHK 467
            |..||||||||||..||||||.||||||:...:|::|||::::|||:|.:|.     .:..|.|.
Human   458 HGRLWSNFWGALSADGYYARSEDYVDIVQGRRVGVWNVPYISNIYLIKGSALRGELQSSDLFHHS 522

  Fly   468 EFDPDMAMCESLRNAGIFMYASNLRIFGHLVNADDFNTTVTRPDFYTLFSNEIDWTEKYIHPNYS 532
            :.|||||.|.::|...:||:.:|....|||::.|.:.||....|.:.:|||..||.|||||.||:
Human   523 KLDPDMAFCANIRQQDVFMFLTNRHTLGHLLSLDSYRTTHLHNDLWEVFSNPEDWKEKYIHQNYT 587

  Fly   533 LQLNESNKIQQPCPDVYWFQIVSDAFCDDLVAIMEAHNGWSDGSNNDNRLEGGYEAVPTRDIHMK 597
            ..| ....::.||||||||.|.::..||:||..||....||.|:|.|||::||||.|||.||||.
Human   588 KAL-AGKLVETPCPDVYWFPIFTEVACDELVEEMEHFGQWSLGNNKDNRIQGGYENVPTIDIHMN 651

  Fly   598 QVGLERLYLKFLQMFVRPLQERAFTGYFHNPPRALMN--FMVRYRPDEQPSLRPHHDSSTYTINI 660
            |:|.||.:.|||..::.|:.|:.:.||:   .||..:  |:|||:|||||||.||||:||:||||
Human   652 QIGFEREWHKFLLEYIAPMTEKLYPGYY---TRAQFDLAFVVRYKPDEQPSLMPHHDASTFTINI 713

  Fly   661 AMNRAGIDYQGGGCRFIRYNCSVTDTKKGWMLMHPGRLTHYHEGLLVTNGTRYIMISFIDP 721
            |:||.|:||:||||||:|||||:...:|||.||||||||||||||..|.|||||.:||:||
Human   714 ALNRVGVDYEGGGCRFLRYNCSIRAPRKGWTLMHPGRLTHYHEGLPTTRGTRYIAVSFVDP 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plod	NP_648451.1	GT_LH	27..257	CDD:459235	95/231 (41%)
		Glyco_tranf_GTA_type	303..>395	CDD:472172	24/92 (26%)
		P4Hc	555..719	CDD:214780	99/165 (60%)
PLOD1	NP_001303249.1	GT_LH1	73..301	CDD:438560	95/231 (41%)
		P4Hc	609..772	CDD:214780	99/165 (60%)