Protein Alignment Plod and Plod3

DIOPT Version :10

• Sequence 1: NP_648451.1
• Gene: Plod / 39265
• FlyBaseID: FBgn0036147
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_835202.2
• Gene: Plod3 / 288583
• RGDID: 631339
• Length: 741
• Species: Rattus norvegicus
• Alignment Length: 741
• Identity: 337/741 - (45%)
• Similarity: 484/741 - (65%)
• Gaps: 26/741 - (3%)

  Fly     3 IQQSALLLLLL-------AVTSQGDAESNWN----DKIKVFTVATEPTDGYTRYIRSARVYDIEV 56
            :.:..||||||       .|||..|.....|    ||:.|.||||..|:||.|:::||..::..|
  Rat     5 VPEPRLLLLLLLLLPPLPPVTSASDRPRGANPVNPDKLLVITVATAETEGYRRFLQSAEFFNYTV 69

  Fly    57 TTLGLGEEWKGGDMQKP-GGGFKLNLLREAIAPYKNEPETIILFTDSYDVIITTTLDEIFEKFKE 120
            .|||||:||:|||:.:. |||.|:..|::.:..|.::.:.||:|.||||||:.::..|:.:||.:
  Rat    70 RTLGLGQEWRGGDVARTVGGGQKVRWLKKEMEKYASQEDMIIMFVDSYDVILASSPTELLKKFVQ 134

  Fly   121 SGAKILFSAEKYCWPDKSLANDYPEVEGKASRFLNSGAFIGYAPQVFALLVD-PIEDTADDQLYF 184
            ||:.:|||||.:||||..||..|||| |...||||||.|||:||.:..::.. ..:|..||||::
  Rat   135 SGSHLLFSAESFCWPDWGLAEQYPEV-GVGKRFLNSGGFIGFAPTIHRIVRQWKYKDDDDDQLFY 198

  Fly   185 TKIFLDETKRAKLGLKLDVQSRLFQNLHGAKNDVKLKVDLESNQGVLQNVDFMTTPSIIHGNGLS 249
            |:::||...|.||.|.||.:||:||||:||.::|.||.|  .|:..::||.:.|.|.::||||.:
  Rat   199 TQLYLDPGLREKLKLSLDHKSRIFQNLNGALDEVVLKFD--QNRVRIRNVAYDTLPVVVHGNGPT 261

  Fly   250 KVDLNAYGNYLAR--TFNGVCLLCQENLLDLEETNLPV-ISLALMVTQPVPFFDQFLEGIESLNY 311
            |:.||..|||:..  |..|.|..|..|...|.....|. :.||:.|.||.||..:||:.:..|:|
  Rat   262 KLQLNYLGNYVPNGWTPQGGCGFCNLNRRTLPGGQPPPRVLLAVFVEQPTPFLPRFLQRLLLLDY 326

  Fly   312 PKEKLHLLIYSNVAFHDDDIKSFVNKHAKEYATAKFALSTDELDERQGRQLALDKARLH-QSDYI 375
            |.:::.|.:::|..:|:..|.....:....::..|.....:.|...:.|.:|:|..|.: :.::.
  Rat   327 PPDRISLFLHNNEVYHEPHIADAWPQLQDHFSAVKLVGPEEALSSGEARDMAMDSCRQNPECEFY 391

  Fly   376 FFVDADAHIDDGEVLRELLRLNKQFVAPIFSKHKELWSNFWGALSEGGYYARSHDYVDIVKRELI 440
            |.:||||.:.:.|.||.|:..|::.:||:.|:|.:||||||||||...|||||.|||::|:|:.:
  Rat   392 FSLDADAVLTNPETLRILIEQNRKVIAPMLSRHGKLWSNFWGALSPDEYYARSEDYVELVQRKRV 456

  Fly   441 GMFNVPHVTSIYLVKKTAF-----DAISFKHKEFDPDMAMCESLRNAGIFMYASNLRIFGHLVNA 500
            |::|||:::..|:::....     :...|...:.|||||.|.|:|:.|||::.||...||.|::.
  Rat   457 GLWNVPYISQAYVIRGETLRTELPEKEVFSSSDTDPDMAFCRSVRDKGIFLHLSNQHEFGRLLST 521

  Fly   501 DDFNTTVTRPDFYTLFSNEIDWTEKYIHPNYSLQLNESNKIQQPCPDVYWFQIVSDAFCDDLVAI 565
            ..::|....||.:.:|.|.:||.|:|||.|||..|:....::|||||||||.::::..||:||..
  Rat   522 SHYDTDHLHPDLWQIFDNPVDWREQYIHENYSRALDGEGLVEQPCPDVYWFPLLTEQMCDELVEE 586

  Fly   566 MEAHNGWSDGSNNDNRLEGGYEAVPTRDIHMKQVGLERLYLKFLQMFVRPLQERAFTGYFHNPPR 630
            ||.:..||.|.:.|:||.||||.|||.||||||||.|..:|:.|:.:|.|:.|..|.|| |...|
  Rat   587 MEHYGQWSGGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTEHLFPGY-HTKTR 650

  Fly   631 ALMNFMVRYRPDEQPSLRPHHDSSTYTINIAMNRAGIDYQGGGCRFIRYNCSVTDTKKGWMLMHP 695
            |:|||:|||||||||||||||||||:|:|:|:|..|:||:||||||:||:|.|:..:|||.|:||
  Rat   651 AVMNFVVRYRPDEQPSLRPHHDSSTFTLNVALNHKGVDYEGGGCRFLRYDCRVSSPRKGWALLHP 715

  Fly   696 GRLTHYHEGLLVTNGTRYIMISFIDP 721
            ||||||||||..|.||||||:||:||
  Rat   716 GRLTHYHEGLPTTRGTRYIMVSFVDP 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plod	NP_648451.1	GT_LH	27..257	CDD:459235	109/231 (47%)
		Glyco_tranf_GTA_type	303..>395	CDD:472172	23/92 (25%)
		P4Hc	555..719	CDD:214780	102/163 (63%)
Plod3	NP_835202.2	Required for glycosyltransferase activity. /evidence=ECO:0000250|UniProtKB:O60568	28..293		119/267 (45%)
		GT_LH3	40..269	CDD:438558	109/231 (47%)
		Accessory region. /evidence=ECO:0000250|UniProtKB:O60568	298..523		79/224 (35%)
		Glyco_tranf_2_3	298..>443	CDD:433372	49/144 (34%)
		P4Hc	576..739	CDD:214780	102/163 (63%)
		Important for dimerization. /evidence=ECO:0000250|UniProtKB:O60568	675..718		25/42 (60%)