Protein Alignment Plod and Plod3

DIOPT Version :10

• Sequence 1: NP_648451.1
• Gene: Plod / 39265
• FlyBaseID: FBgn0036147
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_036092.1
• Gene: Plod3 / 26433
• MGIID: 1347008
• Length: 741
• Species: Mus musculus
• Alignment Length: 733
• Identity: 335/733 - (45%)
• Similarity: 484/733 - (66%)
• Gaps: 23/733 - (3%)

  Fly     8 LLLLLL----AVTSQGDAESNWN----DKIKVFTVATEPTDGYTRYIRSARVYDIEVTTLGLGEE 64
            ||||||    .|||..|.....|    ||:.|.||||..|:||.|:::||..::..|.|||||:|
Mouse    13 LLLLLLPPLPPVTSASDRPRGANAVNPDKLLVITVATAETEGYRRFLQSAEFFNYTVRTLGLGQE 77

  Fly    65 WKGGDMQKP-GGGFKLNLLREAIAPYKNEPETIILFTDSYDVIITTTLDEIFEKFKESGAKILFS 128
            |:|||:.:. |||.|:..|::.:..|.::.:.||:|.||||||:.::..|:.:||.:||:.:|||
Mouse    78 WRGGDVARTVGGGQKVRWLKKEMEKYADQKDMIIMFVDSYDVILASSPTELLKKFVQSGSHLLFS 142

  Fly   129 AEKYCWPDKSLANDYPEVEGKASRFLNSGAFIGYAPQVFALLVD-PIEDTADDQLYFTKIFLDET 192
            ||.:|||:..||..|||| |...||||||.|||:||.:..::.. ..:|..||||::|:::||..
Mouse   143 AESFCWPEWGLAEQYPEV-GMGKRFLNSGGFIGFAPTIHQIVRQWNYKDDDDDQLFYTQLYLDPG 206

  Fly   193 KRAKLGLKLDVQSRLFQNLHGAKNDVKLKVDLESNQGVLQNVDFMTTPSIIHGNGLSKVDLNAYG 257
            .|.||.|.||.:||:||||:||.::|.||.|  .|:..::||.:.|.|.::||||.:|:.||..|
Mouse   207 LREKLKLSLDHKSRIFQNLNGALDEVILKFD--QNRVRIRNVAYDTLPVVVHGNGPTKLQLNYLG 269

  Fly   258 NYLAR--TFNGVCLLCQENLLDLEETNLPV-ISLALMVTQPVPFFDQFLEGIESLNYPKEKLHLL 319
            ||:..  |..|.|..|.:.|..|.....|. :.||:.|.||.||..:||:.:..|:||.:::.|.
Mouse   270 NYVPNGWTPQGGCGFCNQTLRTLPGGQPPPRVLLAVFVEQPTPFLPRFLQRLLLLDYPPDRISLF 334

  Fly   320 IYSNVAFHDDDIKSFVNKHAKEYATAKFALSTDELDERQGRQLALDKARLH-QSDYIFFVDADAH 383
            ::::..:|:..|.....:....::..|.....:.|...:.|.:|:|..|.: :.::.|.:||||.
Mouse   335 LHNSEVYHEPHIADAWPQLQDHFSAVKLVGPEEALSAGEARDMAMDSCRQNPECEFYFSLDADAV 399

  Fly   384 IDDGEVLRELLRLNKQFVAPIFSKHKELWSNFWGALSEGGYYARSHDYVDIVKRELIGMFNVPHV 448
            :.:.|.||.|:..|::.:||:.|:|.:||||||||||...|||||.|||::|:|:.:|::|||::
Mouse   400 LTNPETLRVLIEQNRKVIAPMLSRHGKLWSNFWGALSPNEYYARSEDYVELVQRKRVGVWNVPYI 464

  Fly   449 TSIYLVK----KTAFDAIS-FKHKEFDPDMAMCESLRNAGIFMYASNLRIFGHLVNADDFNTTVT 508
            :..|:::    :|...... |...:.|||||.|:|:|:.|||::.||...||.|:....::|...
Mouse   465 SQAYVIRGETLRTELPQKEVFSSSDTDPDMAFCKSVRDKGIFLHLSNQHEFGRLLATSRYDTDHL 529

  Fly   509 RPDFYTLFSNEIDWTEKYIHPNYSLQLNESNKIQQPCPDVYWFQIVSDAFCDDLVAIMEAHNGWS 573
            .||.:.:|.|.:||.|:|||.|||..|:....::|||||||||.::::..||:||..||.:..||
Mouse   530 HPDLWQIFDNPVDWREQYIHENYSRALDGEGLVEQPCPDVYWFPLLTEQMCDELVEEMEHYGQWS 594

  Fly   574 DGSNNDNRLEGGYEAVPTRDIHMKQVGLERLYLKFLQMFVRPLQERAFTGYFHNPPRALMNFMVR 638
            .|.:.|:||.||||.|||.||||||||.|..:|:.|:.:|.|:.|..|.|| |...||:|||:||
Mouse   595 GGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTEYLFPGY-HTKTRAVMNFVVR 658

  Fly   639 YRPDEQPSLRPHHDSSTYTINIAMNRAGIDYQGGGCRFIRYNCSVTDTKKGWMLMHPGRLTHYHE 703
            |||||||||||||||||:|:|:|:|..|:||:||||||:||:|.::..:|||.|:||||||||||
Mouse   659 YRPDEQPSLRPHHDSSTFTLNVALNHKGVDYEGGGCRFLRYDCRISSPRKGWALLHPGRLTHYHE 723

  Fly   704 GLLVTNGTRYIMISFIDP 721
            ||..|.||||||:||:||
Mouse   724 GLPTTRGTRYIMVSFVDP 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plod	NP_648451.1	GT_LH	27..257	CDD:459235	108/231 (47%)
		Glyco_tranf_GTA_type	303..>395	CDD:472172	22/92 (24%)
		P4Hc	555..719	CDD:214780	101/163 (62%)
Plod3	NP_036092.1	Required for glycosyltransferase activity. /evidence=ECO:0000250|UniProtKB:O60568	28..293		118/267 (44%)
		GT_LH3	40..269	CDD:438558	108/231 (47%)
		Accessory region. /evidence=ECO:0000250|UniProtKB:O60568	298..523		79/224 (35%)
		Glyco_tranf_2_3	298..>458	CDD:433372	56/159 (35%)
		P4Hc	576..739	CDD:214780	101/163 (62%)
		Important for dimerization. /evidence=ECO:0000250|UniProtKB:O60568	675..718		24/42 (57%)