DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment APP-BP1 and UBA6

DIOPT Version :9

Sequence 1:	NP_001261699.1	Gene:	APP-BP1 / 39244	FlyBaseID:	FBgn0261112	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_060697.4	Gene:	UBA6 / 55236	HGNCID:	25581	Length:	1052	Species:	Homo sapiens

Alignment Length:	510	Identity:	101/510 - (19%)
Similarity:	177/510 - (34%)	Gaps:	143/510 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SPELSDKSKKYDRQIRLWGEHGQTLLEAATVCLVNVTAVGCETAKGLVLPGIGGFTVADGSTVKE 72
            |.|:.|  ..|.||..:.|:.....:..:.|.|..:..:|.|.||.|||.||...|:.|....:.
Human    36 SVEIDD--ALYSRQRYVLGDTAMQKMAKSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQA 98

  Fly    73 EDLGNNFFL--DSSYLGKSKALACMQLLQELNPDVNGDYVDESADFLLANRPNFFDSFDLVIASN 135
            .|||.||||  |.....:::|.|.::.:.||||.|:  ....|..|......:|.|.:..|:
Human    99 WDLGTNFFLSEDDVVNKRNRAEAVLKHIAELNPYVH--VTSSSVPFNETTDLSFLDKYQCVV--- 158

  Fly   136 LNEQTLLLLAERLWELNVPLIYCRSLGMLGTIRLQIREHCIVEAHPDNRQFDLRLEHPFDALREH 200
                        |.|:.:||            :.:|.:.|..:..|..          |.:...|
Human   159 ------------LTEMKLPL------------QKKINDFCRSQCPPIK----------FISADVH 189

  Fly   201 LDGTEVTSKVPWLLVLHKYLNVWQKQQADGTQTPRNYKEKNQLKETIREEMKADEENYEEAIKAV 265
                                .:|.:...|       :.::.::.:|..||.|   |.:...|...
Human   190 --------------------GIWSRLFCD-------FGDEFEVLDTTGEEPK---EIFISNITQA 224

  Fly   266 NTAFGAGQVPKSLKAIFEDDACEQLNKKSNVFWIMAKALKHFVIHENEGHLPLPGVLPDMTANTD 330
            |        |..:..:                             ||..|          ...|.
Human   225 N--------PGIVTCL-----------------------------ENHPH----------KLETG 242

  Fly   331 SYIALQHIYRQQALQDADQVYHKCQEYLKQLALPAD---SIDERSVRLICKEAAGLAVIRGTRIA 392
            .::..:.|.....|..:          ::|:.:.:.   ||.: :..|......|:||...|...
Human   243 QFLTFREINGMTGLNGS----------IQQITVISPFSFSIGD-TTELEPYLHGGIAVQVKTPKT 296

  Fly   393 EEYEKSSRLLP-----LVEDNELQGNLTAYNFALRAYERFLSECGNIPG-ECIVEQDIGRLKSIA 451
            ..:|...|.|.     :|:.:..:..|..:. |:.|.::|..:....|. .|  :||...|..:|
Human   297 VFFESLERQLKHPKCLIVDFSNPEAPLEIHT-AMLALDQFQEKYSRKPNVGC--QQDSEELLKLA 358

  Fly   452 AKMLSDLGMHATISDDVLHEICRYGGAELHAVSAFIGGCAAQEVIKIITKQYKPI 506
            ..:...|.....::.|::|.:.......|..::|.:||.|:|||:|.:|.::.|:
Human   359 TSISETLEEKPDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPL 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
APP-BP1	NP_001261699.1	APPBP1_RUB	16..522	CDD:238770	98/502 (20%)
APP-BP1	NP_001261699.1	ThiF	17..>171	CDD:223552	41/155 (26%)
UBA6	NP_060697.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Ube1	38..1046	CDD:273603	100/508 (20%)
		Ube1_repeat1	43..432	CDD:238768	98/501 (20%)
		E1_4HB	299..361	CDD:292809	14/64 (22%)
		Ube1_repeat2	462..1005	CDD:238767
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810