Protein Alignment simj and GATAD2A

DIOPT Version :10

• Sequence 1: NP_001261685.1
• Gene: simj / 39212
• FlyBaseID: FBgn0010762
• Length: 937
• Species: Drosophila melanogaster
• Sequence 2: NP_001371466.1
• Gene: GATAD2A / 54815
• HGNCID: 29989
• Length: 685
• Species: Homo sapiens
• Alignment Length: 707
• Identity: 207/707 - (29%)
• Similarity: 281/707 - (39%)
• Gaps: 241/707 - (34%)

  Fly   112 GATSGSIGGGQDENKVQRRVLRPRTEPKSYAEAPDIVLLPARTNGRQQNGNIDSETDDEEMP--- 173
            |...|.:|.|..:.:.....::....|.|    ||:::|                 .|.|.|
Human    72 GRGEGLVGDGPVDMRTSHSDMKSERRPPS----PDVIVL-----------------SDNEQPSSP 115

  Fly   174 -----PYVPIKELSHAEL-----KEREKSLRKLRQDLRNEETKLMLLKKLKQSQQVMKENLVVTP 228
                 ..|.:||.|...|     :|||:.:::|:::||.||.||:|||||:|| |:.||.....|
Human   116 RVNGLTTVALKETSTEALMKSSPEERERMIKQLKEELRLEEAKLVLLKKLRQS-QIQKEATAQKP 179

  Fly   229 TSVSPNNPLSAIPAALTSKGSLSVTPTSAVPLPAHSKGSRSSLSGSGGPAVSISATNSRTGSSSS 293
            |                  ||:..|.|:..||   .:|:::..:|.  |::..|
Human   180 T------------------GSVGSTVTTPPPL---VRGTQNIPAGK--PSLQTS----------- 210

  Fly   294 AAAAASAIAAAAMSGQHRSGSNSILPPP------RSSLPAGATLAAGTTITPATSSS-------- 344
                     :|.|.|       |::|||      ::|...|...::...:.|....:
Human   211 ---------SARMPG-------SVIPPPLVRGGQQASSKLGPQASSQVVMPPLVRGAQQIHSIRQ 259

  Fly   345 HRSSNLPPRTNLPNLTITPSVTITPTSAPPSSL-KPRNVPGTISNSVSITPALPLSQSHQNQHND 408
            |.|:..||....|..:: |||.|.........| :..|||.| |..|:|....|.|.......:.
Human   260 HSSTGPPPLLLAPRASV-PSVQIQGQRIIQQGLIRVANVPNT-SLLVNIPQPTPASLKGTTATSA 322

  Fly   409 QKNDRSTPRE------DAQTPAQRQAAAKMALRKQLEKTLLQIPPPKPPPPEMHFIPNPSNTDFV 467
            |.|  |||..      .|::||.||||||:|||||||||||:|||||||.|||:|:|:.:|.:|:
Human   323 QAN--STPTSVASVVTSAESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFI 385

  Fly   468 YLLGLETVVDYL--------------------------------------------------TVN 482
            ||:|||.||..|                                                  .|.
Human   386 YLVGLEEVVQNLLETQGPHCGRDFEPCWRHLLTPPRAPSLAPCLVLAPLTLAMGWTCARRCAVVT 450

  Fly   483 KKANAVAA-------PFRCAQCKIDFTPVWKWEKQTNKDPKVICEQCVTSNVKKALKAEHTNRLK 540
            :.:..::|       |:.|||||.|||..|:.|    |...::||.|:|:|.|||||.|||:|||
Human   451 RASGRMSAATVLSREPYMCAQCKTDFTCRWREE----KSGAIMCENCMTTNQKKALKVEHTSRLK 511

  Fly   541 QAFVKALQQEQEIEQRLASQ------------SSPSPVDNH---------GSSGGGNSLSVSAVS 584
            .||||||||||||||||..|            ::|.||...         ..||.....|..||.
Human   512 AAFVKALQQEQEIEQRLLQQGTAPAQAKAEPTAAPHPVLKQVIKPRRKLAFRSGEARDWSNGAVL 576

  Fly   585 SNSSSSHMQREREQLQASHASAAAALVNLPPSVTVIPTKCQTPTPATPR-------PTPPPPQS- 641
            ..||           |.|..||                       .|||       |:|....|
Human   577 QASS-----------QLSRGSA-----------------------TTPRGVLHTFSPSPKLQNSA 607

  Fly   642 QATPPPSSGGSRSSRAAATAAAAAIAAQQAGILSPG-------PSPAHHHEPTTSSR 691
            .||...|..|..|.|..:....:|.:..:...||.|       ||.|.|...:...|
Human   608 SATALVSRTGRHSERTVSAGKGSATSNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDR 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
simj	NP_001261685.1	P66_CC	185..225	CDD:465178	21/44 (48%)
GATAD2A	NP_001371466.1	Med21	<98..167	CDD:463241	28/89 (31%)
		P66_CC	137..176	CDD:465178	20/39 (51%)
		GATA	469..503	CDD:425605	19/37 (51%)
		ser_rich_anae_1	<565..>672	CDD:468206	31/134 (23%)