Protein Alignment Gem3 and mel-46

DIOPT Version :10

• Sequence 1: NP_524019.1
• Gene: Gem3 / 39195
• FlyBaseID: FBgn0011802
• Length: 1028
• Species: Drosophila melanogaster
• Sequence 2: NP_001255909.1
• Gene: mel-46 / 178469
• WormBaseID: WBGene00020284
• Length: 973
• Species: Caenorhabditis elegans
• Alignment Length: 1038
• Identity: 241/1038 - (23%)
• Similarity: 434/1038 - (41%)
• Gaps: 213/1038 - (20%)

  Fly    14 ERSSDVAPGQVKTFEELRLYRNLLNGLKRNNFVTPTKIQAAAIPMALAKMDLIIQSKSGTGKTLI 78
            :|.|.:......|||.|.:.:..|..||.:.|..|:.:||.|||:.|...|:::|:||||||||:
 Worm    11 DRGSSIDVQSNCTFESLMIGQKTLERLKNSQFDRPSPVQARAIPVGLLGRDMLVQAKSGTGKTLV 75

  Fly    79 YVIAVVQSFNPNINQPHAMIVVPTRELAIQVQDTFFHLCKSFRDFKCSAFIGGT-------DVAK 136
            :.:..|::.:...:....:||.||||:::|:::|...:..:  ..:.|.::||:       |:.:
 Worm    76 FSVLAVENLDSRSSHIQKVIVTPTREISVQIKETVRKVAPT--GARTSVYVGGSAHKLNLIDLKQ 138

  Fly   137 DRKRMNESRVIIGTPGRLLHLYENRVFDVSKLRLLVLDEADQLYQTKSLQHTVSKLIEAMPKNRQ 201
            .|     .:::||||||:..|.:....::|.:...||||||:| ..:..:..::.:|.::|:.||
 Worm   139 TR-----PQIVIGTPGRIAQLVKLGAMNMSHVDFFVLDEADKL-MDEVFRDDINIIINSLPQIRQ 197

  Fly   202 IIACSATYDQNLDERLAKVMDKPMLISNSERATVLLGIRQFVYELPQQNNSVEEMRLKLQILGQI 266
            :...||||.:|||..|:..:....|:..:.....|.||:|:|         |.:....|:.|..:
 Worm   198 VAVFSATYPRNLDNLLSTFLRDAALVRFNADDVQLFGIKQYV---------VAKCSPMLEKLTHV 253

  Fly   267 FNQLPYEQAIIFASSQMRADSYKNYLTASGIDCHLISGAMEQSERLHVFEGYRNFTMRILVATDL 331
            ...:.|.||::|.....:.:....:|.:||:|...:|.||.|.:|....:..|...::|||::||
 Worm   254 LKSIRYVQALVFCDQISKCEPIATHLKSSGLDVTFVSSAMSQKDRQLAVDQLRAKRVKILVSSDL 318

  Fly   332 MARGVDSPHANLVINIDPPQDHVTYLHRIGRAGRFGSKGIAITFIASKKESQRFREMS------- 389
            .|||:|:.:.|||:|||...:..||.||||||.|||:.|.|:|.:..::..:.|..::
 Worm   319 TARGIDADNVNLVVNIDAAANEETYFHRIGRAARFGAHGAAVTLLEDERALKGFTALAYRGKVTV 383

  Fly   390 KKIATAWSVLEFPKEPMPNEFNFWDFEKYNFDYYIKEENPLQEMPMPIKENRSKENVDASSVDLE 454
            |::..  .|.|.|.:.:.|: .||.    :..|:|..|.|      |...|...:..|..|. :|
 Worm   384 KRVVE--GVHELPGDLVKNQ-EFWK----DLPYFIDFETP------PTGPNDLNKVPDRQSA-VE 434

  Fly   455 NLQKDQD--------GKRRDPDKLPVALENVETQKELE-----LENLPESSHNNKNLRVKEKEIV 506
            :|:.:::        .|:...|::.....:.:.::.:|     :|||...:..::...|.|.:..
 Worm   435 SLKSEREASGIVTSSSKKYTRDEMMAMRSDTKNEQSVEEISAKIENLSVETETDEKENVVEVKKT 499

  Fly   507 RQGKLKETNSKAGGSKTNKTERRKKSNTPSKLQKQITEVQQTPEITVNKYYMQEDIQRTADG--- 568
            .:.:|.|..:....:|:.......||...||.     :...|.|....||||:.::|...:.
 Worm   500 FKERLAELKAAKAAAKSQTEPEAPKSEPKSKF-----KFVPTREKAKKKYYMRGELQHIREAFTS 559

  Fly   569 ---KEY--------------HPV--NGAGNHQVPSKSNQKPVEFISPELTPTLTPLELTQEPSPT 614
               :.|              .||  ..|.|.|:.|..:....|.        |..:|.|::..|.
 Worm   560 EQWRAYAETKFDFTEEPFLGGPVESKSAENSQISSSGDVGKAEI--------LENVEKTEQNPPK 616

  Fly   615 TVTPPAPPANS---INNKTYCLAAPTQTS--SMTIQNMVISNTVD--DASSISSDSMVVCGYHSD 672
            .:........|   :.|.......|.:.|  |...:|..||::.|  .|..:.:....|......
 Worm   617 IIKSRNVQIGSQEDVGNSKNAEKTPLRGSEASKNAENSQISSSGDIGKAEILENGENPVKNPPKT 681

  Fly   673 RSYDTYYATSDEEEI------------WN-----------------RLMSKQRRQLKSKRGHGKR 708
            ..|:.:.....::|:            ||                 ..:.:||::.|.:|    |
 Worm   682 IKYNRFEMKKIQKEVPKDSWIPYVKSKWNTTEEPWELDQWLRCPFEERLRRQRKREKDER----R 742

  Fly   709 RVILYKKVFPKLKANVKRKLKKR--MSSSCRSKKAHHLRKRHVYKNISLLPHMNLCHLLQKFTNQ 771
            :||..:|         ||:.:.|  :.||.|..|...:|:                      |:.
 Worm   743 KVIEDRK---------KRRDEDRQELVSSGRITKVVEIRE----------------------TSW 776

  Fly   772 ERFLKRLHK-------YAKNQFIDNA-----RVGFLLDK-----LYKSILEMYYNSAKERKKHFK 819
            :.:..|:.:       ..:....:.|     |:|.::.:     :|:..::||.....|:..:.:
 Worm   777 QDYQARVRREFEEATEKRRKMMTEGAAEVLRRIGPVVPQRTPPLIYRYRVDMYKRRLDEQDAYLQ 841

  Fly   820 EAMKESLKSIDNYESQESSESEEEEEEEKDLKNKLSVHVTNQMDIPPMPQAAVEIGSGSESDTED 884
            ...|.....:...|:|.::|:.|:..|        .|.:..|.|......|..|.....|...|:
 Worm   842 HQNKLDDGILKETEAQTTAENPEKSME--------MVEIECQTDEIQEELAEDEEYWDEEYWDEE 898

  Fly   885 SQEYGEGEEIIVDD------EDDGSDGGPNSS-------------SGFVES---QESVSSGID 925
            ..|..||.:.|.||      |.:||:|...:|             :|::.:   |.:..|.||
 Worm   899 ELEGSEGSQEIFDDFPDVVEELEGSEGSEEASEAAPRAPQLEHLAAGYLRNMNFQAATQSYID 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gem3	NP_524019.1	SrmB	26..409	CDD:440279	123/396 (31%)
mel-46	NP_001255909.1	DEADc_DDX20	33..224	CDD:350701	63/198 (32%)
		SF2_C_DEAD	235..363	CDD:350174	49/136 (36%)
		PTZ00121	<429..>882	CDD:173412	86/509 (17%)