Protein Alignment Gem3 and Eif4a2

DIOPT Version :10

• Sequence 1: NP_524019.1
• Gene: Gem3 / 39195
• FlyBaseID: FBgn0011802
• Length: 1028
• Species: Drosophila melanogaster
• Sequence 2: NP_001334108.1
• Gene: Eif4a2 / 13682
• MGIID: 106906
• Length: 408
• Species: Mus musculus
• Alignment Length: 419
• Identity: 125/419 - (29%)
• Similarity: 205/419 - (48%)
• Gaps: 48/419 - (11%)

  Fly    24 VKTFEELRLYRNLLNGLKRNNFVTPTKIQAAAIPMALAKMDLIIQSKSGTGKTLIYVIAVVQSFN 88
            |..|:::.|..:||.|:....|..|:.||..||...:...|:|.|::||||||..:.|:::|...
Mouse    33 VDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLE 97

  Fly    89 PNINQPHAMIVVPTRELAIQVQDTFFHLCKSFRDFKCSAFIGGTDVAKDRKRMNES--RVIIGTP 151
            ....:..|:::.||||||.|:|.....| ..:....|.|.||||:|..:.:::...  .:::|||
Mouse    98 IEFKETQALVLAPTRELAQQIQKVILAL-GDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTP 161

  Fly   152 GRLLHLYENRVFDVSKLRLLVLDEADQLYQTKSLQHTVSKLIEAMPKNRQIIACSATYDQNLDER 216
            ||:..:...|......:::.||||||::. ::..:..:.::.:.:..:.|::..|||...::.|.
Mouse   162 GRVFDMLNRRYLSPKWIKMFVLDEADEML-SRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEV 225

  Fly   217 LAKVMDKPMLISNSERATVLLGIRQFVYELPQQNNSVEEMRLKLQILGQIFNQLPYEQAIIFASS 281
            ..|.|..|:.|...:....|.||:||..       :||....||..|..::..|...||:||.::
Mouse   226 TKKFMRDPIRILVKKEELTLEGIKQFYI-------NVEREEWKLDTLCDLYETLTITQAVIFLNT 283

  Fly   282 QMRADSYKNYLTASGIDCHLISGAMEQSERLHVFEGYRNFTMRILVATDLMARGVDSPHANLVIN 346
            :.:.|.....:.|.......:.|.|:|.||..:...:|:.:.|:|:.|||:|||:|....:||||
Mouse   284 RRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVIN 348

  Fly   347 IDPPQDHVTYLHRIGRAGRFGSKGIAITFIASKKESQRFREMSKKIATAWSVLEFPKEPMPNEFN 411
            .|.|.:...|:|||||.||||.||:||.|:.         |..|:|..
Mouse   349 YDLPTNRENYIHRIGRGGRFGRKGVAINFVT---------EEDKRILR----------------- 387

  Fly   412 FWDFEK-YNFDYYIKEENPLQEMPMPIKE 439
              |.|. ||        ..::||||.:.:
Mouse   388 --DIETFYN--------TTVEEMPMNVAD 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gem3	NP_524019.1	SrmB	26..409	CDD:440279	116/384 (30%)
Eif4a2	NP_001334108.1	DEAD-like_helicase_N	9..408	CDD:475120	125/419 (30%)
		Q motif	34..62		8/27 (30%)
		DEAD box	184..187		2/2 (100%)