Protein Alignment Gem3 and DDX20

DIOPT Version :10

• Sequence 1: NP_524019.1
• Gene: Gem3 / 39195
• FlyBaseID: FBgn0011802
• Length: 1028
• Species: Drosophila melanogaster
• Sequence 2: NP_009135.4
• Gene: DDX20 / 11218
• HGNCID: 2743
• Length: 824
• Species: Homo sapiens
• Alignment Length: 786
• Identity: 206/786 - (26%)
• Similarity: 347/786 - (44%)
• Gaps: 132/786 - (16%)

  Fly     6 AHSLAGGEERSSDVAPGQVKTFEELRLYRNLLNGLKRNNFVTPTKIQAAAIPMALAKMDLIIQSK 70
            |..|:....|:.||...:...||.|.|.|.:|.||:...|..|:.:|..|||:....:|||:|:|
Human    43 AQDLSSPRTRTGDVLLAEPADFESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAK 107

  Fly    71 SGTGKTLIYVIAVVQSFNPNINQPHAMIVVPTRELAIQVQDTFFHLCKSFRDFKCSAFIGGTDVA 135
            ||||||.::....:.|..........:|:.||||:|:|:......:.......:|..|||||.::
Human   108 SGTGKTCVFSTIALDSLVLENLSTQILILAPTREIAVQIHSVITAIGIKMEGLECHVFIGGTPLS 172

  Fly   136 KDRKRMNESRVIIGTPGRLLHLYENRVFDVSKLRLLVLDEADQLYQTKSLQHTVSKLIEAMPKNR 200
            :|:.|:.:..:.:|:|||:..|.|....:...:||.:|||||:|.:..|.|..::.:..::|.::
Human   173 QDKTRLKKCHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGSFQEQINWIYSSLPASK 237

  Fly   201 QIIACSATYDQNLDERLAKVMDKPMLISNSERATVLLGIRQF---VYELPQQNNSVEEMRLKLQI 262
            |::|.||||.:.|...|.|.|..|..:..:.....|:|::|:   |...|..:...||   |.|.
Human   238 QMLAVSATYPEFLANALTKYMRDPTFVRLNSSDPSLIGLKQYYKVVNSYPLAHKVFEE---KTQH 299

  Fly   263 LGQIFNQLPYEQAIIFASSQMRADSYKNYLTASGIDCHLISGAMEQSERLHVFEGYRNFTMRILV 327
            |.::|:::|:.||::|::...||....:.|::.|.....|||.|.|::||......::|..|:|:
Human   300 LQELFSRIPFNQALVFSNLHSRAQHLADILSSKGFPAECISGNMNQNQRLDAMAKLKHFHCRVLI 364

  Fly   328 ATDLMARGVDSPHANLVINIDPPQDHVTYLHRIGRAGRFGSKGIAITFIASKKESQRFREMSKKI 392
            :|||.:||:|:...|||:|:|.|.|..||:||||||||||:.|:.:|:....:|......:::|.
Human   365 STDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYCCRGEEENMMMRIAQKC 429

  Fly   393 ATAWSVLEFPKEPMPN----EFNFWDFE-KYNFDYYIKEENPLQEMPMPIKENRSKENVDASSVD 452
            ..  ::|..| :|:|:    |...||.| |.....|.....|.|    |:|:...|..   .::.
Human   430 NI--NLLPLP-DPIPSGLMEECVDWDVEVKAAVHTYGIASVPNQ----PLKKQIQKIE---RTLQ 484

  Fly   453 LENLQKDQDGKRRDPDKLPVALENVETQKELELENLPESSHNNKNLRVKEKEIVRQGKLKETNSK 517
            ::....|.....|:.....:::::....|    :.||..||:       |..|:.    |.|:.|
Human   485 IQKAHGDHMASSRNNSVSGLSVKSKNNTK----QKLPVKSHS-------ECGIIE----KATSPK 534

  Fly   518 AGGSKTNKTERRKKS-NTP----SKLQKQITE-----VQQTPEITVNK----------------- 555
            ..|......|:.|.| .||    :..|.|:.|     :.|.|.::..|
Human   535 ELGCDRQSEEQMKNSVQTPVENSTNSQHQVKEALPVSLPQIPCLSSFKIHQPYTLTFAELVEDYE 599

  Fly   556 YYMQEDIQR--------TADGKE-YHPVNGAGNHQV----------------------------- 582
            :|::|.:::        |..|.: .:|.||...::|
Human   600 HYIKEGLEKPVEIIRHYTGPGDQTVNPQNGFVRNKVIEQRVPVLASSSQSGDSESDSDSYSSRTS 664

  Fly   583 -PSKSNQKPVEFIS------PELTPTLTPLELTQEPSPTTVTPPAPPANS--INNKTYCLAAPTQ 638
             .||.|:..:|..|      .|.||....:.|.|.|:.:....|.....|  |..||......:|
Human   665 SQSKGNKSYLEGSSDNQLKDSESTPVDDRISLEQPPNGSDTPNPEKYQESPGIQMKTRLKEGASQ 729

  Fly   639 TSSMTIQNMVISNTVDDASSISSDSMVVCGYHSD--------------------RSYDTYYATSD 683
            .:..:.:|:...::....:....|....|  |.:                    |::..|||.:.
Human   730 RAKQSRRNLPRRSSFRLQTEAQEDDWYDC--HREIRLSFSDTYQDYEEYWRAYYRAWQEYYAAAS 792

  Fly   684 EEEIWN 689
            ....||
Human   793 HSYYWN 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gem3	NP_524019.1	SrmB	26..409	CDD:440279	131/389 (34%)
DDX20	NP_009135.4	Q motif	62..90		10/27 (37%)
		DEADc_DDX20	73..265	CDD:350701	64/191 (34%)
		DEAD box	211..214		2/2 (100%)
		SF2_C_DEAD	276..413	CDD:350174	54/139 (39%)
		SMN interacting domain	396..488		28/101 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	535..559		6/23 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	642..745		18/102 (18%)