DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10809 and ANKRD27

DIOPT Version :9

Sequence 1:	NP_001163403.1	Gene:	CG10809 / 39159	FlyBaseID:	FBgn0036052	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_115515.2	Gene:	ANKRD27 / 84079	HGNCID:	25310	Length:	1050	Species:	Homo sapiens

Alignment Length:	286	Identity:	70/286 - (24%)
Similarity:	114/286 - (39%)	Gaps:	43/286 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 PTSSPNTHGEWPHMNINLNLNMSSNPSTNASFQLSRDRGEHFALPHLPPLPLNPNASNAEYL--- 124
            |..||....:    :|:...:.||..|.:||.:....:.::..:..|.....:.:.....||
Human   631 PVQSPQRSVD----SISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAVADGDLEMVRYLLEW 691

  Fly   125 ----------------PSLIHPSTLPSGSKSFKMRPRMQRLKHSYSYSNIIVQSNGRKLRTAAST 173
                            |...||  |....|....:.|:.::..|....|:..|.....|..||..
Human   692 TEEDLEDAEDTVSAADPEFCHP--LCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALH 754

  Fly   174 CNIELLNRILEGGANPNAADEYNRSPLHLAACRGYIPIVQQLLKYGANPNVVDSLGNTPLHLAVI 238
            ...:|:..:|:.|||..|.:.....|||||..:|:..:|:.||...|.||..|..|||||    |
Human   755 GRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPL----I 815

  Fly   239 SASSNNFNVVVGVLLQGGASVHMYDRSNKSPLELAEAKLRLLRNRYDHPTPETAKILEDMCMLTT 303
            .|.|...:.:|.:|||.|||::.  .:||....|.||.:            |....:.::.:|..
Human   816 YACSGGHHELVALLLQHGASINA--SNNKGNTALHEAVI------------EKHVFVVELLLLHG 866

  Fly   304 LILRYMVKQQRELEDLSALEKRLQNL 329
            ..::.:.|:||...|.:....::..|
Human   867 ASVQVLNKRQRTAVDCAEQNSKIMEL 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10809	NP_001163403.1	Ank_2	167..263	CDD:289560	37/95 (39%)
		ANK repeat	167..193	CDD:293786	9/25 (36%)
		ANK	170..276	CDD:238125	40/105 (38%)
		ANK repeat	195..226	CDD:293786	12/30 (40%)
		ANK repeat	228..263	CDD:293786	15/34 (44%)
ANKRD27	NP_115515.2	Sufficient for GEF activity towards RAB21. /evidence=ECO:0000269\|PubMed:16525121	1..372
		VPS9	264..363	CDD:308039
		Sufficient for interaction with VPS29. /evidence=ECO:0000269\|PubMed:24856514	396..460
		Interaction with RAB32. /evidence=ECO:0000250\|UniProtKB:Q3UMR0	451..730		18/104 (17%)
		Interaction with RAB38. /evidence=ECO:0000250\|UniProtKB:Q3UMR0, ECO:0000269\|PubMed:18477474	451..600
		ANK	458..585	CDD:238125
		ANK repeat	462..493	CDD:293786
		ANK repeat	495..526	CDD:293786
		ANK repeat	564..595	CDD:293786
		Ank_2	<567..>896	CDD:330894	70/286 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	625..665		9/37 (24%)
		Required for interaction with VAMP7. /evidence=ECO:0000250\|UniProtKB:Q3UMR0, ECO:0000269\|PubMed:19745841, ECO:0000269\|PubMed:23104059	658..707		3/48 (6%)
		ANK repeat	673..741	CDD:293786	11/69 (16%)
		Sufficient for interaction with VPS29. /evidence=ECO:0000269\|PubMed:24856514	692..746		9/55 (16%)
		ANK	738..863	CDD:238125	45/142 (32%)
		ANK repeat	743..774	CDD:293786	9/30 (30%)
		ANK 8	743..772		8/28 (29%)
		ANK 9	776..805		11/28 (39%)
		ANK repeat	780..807	CDD:293786	12/26 (46%)
		ANK repeat	809..840	CDD:293786	15/36 (42%)
		ANK 10	809..838		15/32 (47%)
		ANK repeat	842..873	CDD:293786	6/42 (14%)
		ANK 11	842..871		6/40 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	987..1050
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910