DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10809 and tp53bp2b

DIOPT Version :9

Sequence 1:	NP_001163403.1	Gene:	CG10809 / 39159	FlyBaseID:	FBgn0036052	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	XP_005161866.1	Gene:	tp53bp2b / 568138	ZFINID:	ZDB-GENE-050208-453	Length:	1063	Species:	Danio rerio

Alignment Length:	299	Identity:	77/299 - (25%)
Similarity:	116/299 - (38%)	Gaps:	76/299 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 ITPPPPAMPPTPTSSPNTHGEWPHMNINLNLNMSSNPSTNASFQLSRDR---GEHFALPHL---P 110
            :||||  :||..          |.::.|.|.:...|..     ||..::   |.....|::   |
Zfish   754 LTPPP--LPPRS----------PILDDNSNFSTGLNEP-----QLKEEQEVYGPAAPEPYVEEYP 801

  Fly   111 PLPLNPNASNAEY-----------LPSLIHPSTLPSGSKSFKMRPRMQRLKHSYSYSNIIVQSNG 164
            |.|..|..|..|.           .|.:.....||.|.::...:...:|:.|     .:.|:.|.
Zfish   802 PYPPPPYPSMTEQEGPGEDSINMKAPEVTGQVMLPPGKRTNLRKTGSERINH-----GMRVRFNP 861

  Fly   165 RKLRTAAS-TCNIELLNRILEGGANPNAADEYNRSPLHLAACRGYIPIVQQLLKYGANPNVVDSL 228
            ..|...:| ....:|:.||:....:|:..::...:.||.|.|.|:..||:.|::||.|.|..||.
Zfish   862 LALLLDSSLEGEYDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQYGVNVNAADSD 926

  Fly   229 GNTPLHLAVISASSNNFNVVVGVLLQGGASVHMYDRSNKSPLELAEAKLRLLR------------ 281
            |.||||.|   ||.||.. |...|::.||:|:....|:   |:.|..|...:.
Zfish   927 GWTPLHCA---ASCNNVQ-VCKFLVESGAAVYAMTYSD---LQTAADKCEEMEEGYAQCSQFLYG 984

  Fly   282 --------NR--------YDHPTPETAKILEDMCMLTTL 304
                    ||        ||..:|:.....|..| ||.|
Zfish   985 VQEKMGIMNRGVVYALWDYDGESPDELSFKEGDC-LTVL 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10809	NP_001163403.1	Ank_2	167..263	CDD:289560	35/96 (36%)
		ANK repeat	167..193	CDD:293786	6/26 (23%)
		ANK	170..276	CDD:238125	37/106 (35%)
		ANK repeat	195..226	CDD:293786	12/30 (40%)
		ANK repeat	228..263	CDD:293786	15/34 (44%)
tp53bp2b	XP_005161866.1	RA	<20..82	CDD:214612
		RILP-like	<173..310	CDD:304877
		Ank_2	865..951	CDD:289560	31/89 (35%)
		ANK repeat	865..891	CDD:293786	5/25 (20%)
		ANK	871..982	CDD:238125	37/117 (32%)
		ANK repeat	893..924	CDD:293786	12/30 (40%)
		ANK repeat	926..955	CDD:293786	15/32 (47%)
		SH3_ASPP2	995..1051	CDD:212886	8/29 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910