DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10809 and ankrd54

DIOPT Version :9

Sequence 1:	NP_001163403.1	Gene:	CG10809 / 39159	FlyBaseID:	FBgn0036052	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_001002578.1	Gene:	ankrd54 / 436851	ZFINID:	ZDB-GENE-040718-318	Length:	315	Species:	Danio rerio

Alignment Length:	306	Identity:	100/306 - (32%)
Similarity:	151/306 - (49%)	Gaps:	39/306 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 PTPTSSPNTHGEWPHMNINLNLNMSSNPSTNASFQLSRDRGEHFALPHLPPLPLNPNASNAE--- 122
            |:...:....||.|         |.:..:....|.:||       |..|..|.||.....|:
Zfish    30 PSAGDTEKREGESP---------MEAAGAGTVGFSISR-------LDTLSALRLNRTRPAADTEL 78

  Fly   123 -YLPSLIHPSTLPSGSKSFKMR---PRMQRLKHSYSYSNIIVQS--NGRKLRTAASTCNIELLNR 181
             ||..|..|..|....:|...:   .|::||..:......|.:.  ..::||.||::.:|:.:.|
Zfish    79 RYLHLLWKPGELLQAGRSTPGKITSSRVRRLARARRNMGPIGKDLHAVKRLREAANSNDIDTVRR 143

  Fly   182 ILEGGANPNAADEYNRSPLHLAACRGYIPIVQQLLKYGANPNVVDSLGNTPLHLAVISASSNNFN 246
            :||...:|.|||:..|:.||.::|.|...|||.||.|||:||..|||||||||||   |.:|:..
Zfish   144 LLEDDTDPCAADDKGRTALHFSSCNGNETIVQLLLSYGADPNQRDSLGNTPLHLA---ACTNHVP 205

  Fly   247 VVVGVLLQGGASVHMYDRSNKSPLELAEAKLRLLRNRYDHPTPETAKILEDMCMLTTLILRYM-- 309
            |:. .||:|||.|...||:.::||.||.:||.:|:.. |..:.||.:  .::..:..::..|:
Zfish   206 VIT-TLLRGGARVDALDRAGRTPLHLARSKLNILQEG-DSRSLETLR--GEVTQIIQMLREYLNI 266

  Fly   310 VKQQRELEDLSALEKRLQNLSTSDDQEQVVSQTADELLASVERLSI 355
            :.|..|.|.|..:..:|||..|.:..::|.     :||||...|||
Zfish   267 MGQSEEREKLEHISTQLQNTRTREQVDEVT-----DLLASFTSLSI 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10809	NP_001163403.1	Ank_2	167..263	CDD:289560	47/95 (49%)
		ANK repeat	167..193	CDD:293786	10/25 (40%)
		ANK	170..276	CDD:238125	51/105 (49%)
		ANK repeat	195..226	CDD:293786	15/30 (50%)
		ANK repeat	228..263	CDD:293786	18/34 (53%)
ankrd54	NP_001002578.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49		5/27 (19%)
		ANK 1	124..153		9/28 (32%)
		ANK	129..237	CDD:238125	55/111 (50%)
		Ank_2	129..221	CDD:289560	47/95 (49%)
		ANK repeat	129..155	CDD:293786	10/25 (40%)
		ANK repeat	157..188	CDD:293786	15/30 (50%)
		ANK 2	157..186		14/28 (50%)
		ANK repeat	190..221	CDD:293786	18/34 (53%)
		ANK 3	190..219		18/32 (56%)
		BAR	216..>291	CDD:299863	22/77 (29%)
		ANK 4	223..255		10/34 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BJ6N
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	116	1.000	Inparanoid score	I4798
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1559479at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto41493
orthoMCL	1	0.900	-	-		OOG6_108203
Panther	1	1.100	-	-	LDO	PTHR24197
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5638
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.860