DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10809 and tp53bp2a

DIOPT Version :9

Sequence 1:	NP_001163403.1	Gene:	CG10809 / 39159	FlyBaseID:	FBgn0036052	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_999979.1	Gene:	tp53bp2a / 407983	ZFINID:	ZDB-GENE-040516-8	Length:	1060	Species:	Danio rerio

Alignment Length:	344	Identity:	83/344 - (24%)
Similarity:	133/344 - (38%)	Gaps:	71/344 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GVESAKEEV-EMSMPPSPMSMAMVLAKSTPMPMPTSASK---GIMITPPPPAMPPTPTSSPNTHG 71
            |.::...|| |.::|..|::..:......|.|.|..|.|   .|:|.||.|..|| |...|::..
Zfish   732 GYDAETPEVPEETLPEFPIAPEVEAEDVPPPPPPHPAPKIDASIIIPPPQPESPP-PPPPPDSFM 795

  Fly    72 EWPHMNINLNLNMSSNPSTNASFQLSRDRGEHFALPHLPPLPLNPNASNAEY----------LPS 126
            |                                   ..||.|..|..|:||.          .|.
Zfish   796 E-----------------------------------DFPPYPPPPYPSSAEQDNPDDTFNMKPPE 825

  Fly   127 LIHPSTLPSGSKSFKMRPRMQRLKHSYSYSNIIVQSNGRKLRTAAS-TCNIELLNRILEGGANPN 190
            :......|.|.::...:...:|:.||     :.|:.|...|...:| ....:|:.|::....:|:
Zfish   826 VTGQVPFPPGKRTNLRKSGSERIDHS-----MRVRFNPLALLLDSSLEGEFDLVQRVIYEVEDPS 885

  Fly   191 AADEYNRSPLHLAACRGYIPIVQQLLKYGANPNVVDSLGNTPLHLAVISASSNNFNVVVGVLLQG 255
            ..::...:.||.|.|.|:..||:.|::||.|.|..||.|.||||.|   ||.||.. |...|::.
Zfish   886 QPNDEGITALHNAVCAGHTEIVKFLVQYGVNVNAADSDGWTPLHCA---ASCNNVQ-VCKFLVES 946

  Fly   256 GASVHMYDRSNKSPLELAEAKLRLLRNRYDHPTPETAKILEDMCMLTTLIL----RYMVKQQREL 316
            ||:|.....|:   ::.|..|...:...|...:.....:.|.|.::...::    .|...|:.|.
Zfish   947 GAAVFAMTYSD---MQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNRGVVYGLWDYEAAQEDEC 1008

  Fly   317 E----DLSALEKRLQNLST 331
            .    |..::.:|...|.|
Zfish  1009 SFREGDCMSVIRREDELET 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10809	NP_001163403.1	Ank_2	167..263	CDD:289560	34/96 (35%)
		ANK repeat	167..193	CDD:293786	5/26 (19%)
		ANK	170..276	CDD:238125	35/106 (33%)
		ANK repeat	195..226	CDD:293786	12/30 (40%)
		ANK repeat	228..263	CDD:293786	15/34 (44%)
tp53bp2a	NP_999979.1	UBQ	<22..83	CDD:294102
		RILP-like	<170..301	CDD:304877
		Ank_2	862..948	CDD:289560	30/89 (34%)
		ANK repeat	862..888	CDD:293786	4/25 (16%)
		ANK	868..979	CDD:238125	36/117 (31%)
		ANK repeat	890..921	CDD:293786	12/30 (40%)
		ANK repeat	923..952	CDD:293786	15/32 (47%)
		SH3	992..1048	CDD:302595	7/36 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910