DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10809 and FPGT-TNNI3K

DIOPT Version :9

Sequence 1:	NP_001163403.1	Gene:	CG10809 / 39159	FlyBaseID:	FBgn0036052	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_001106279.3	Gene:	FPGT-TNNI3K / 100526835	HGNCID:	42952	Length:	936	Species:	Homo sapiens

Alignment Length:	200	Identity:	52/200 - (26%)
Similarity:	89/200 - (44%)	Gaps:	52/200 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 NAEYLPSLIHPSTLPSGSKSFKMRPRMQRLKHSYSYSNIIVQSNGRKLRTAASTCNIELLNRILE 184
            |||.:.||:|     ||:.       :|::    .|..:..      |..|....::|..:.:|:
Human   214 NAELITSLLH-----SGAD-------IQQV----GYGGLTA------LHIATIAGHLEAADVLLQ 256

  Fly   185 GGANPNAADEYNRSPLHLAACRGYIPIVQQLLKYGANPNVVDSLGNTPLHLAVISASSNNFNVVV 249
            .|||.|..|....:|||:||..|:..:.:.|||:||:.||...:|:.||||    ||:..|..:.
Human   257 HGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHL----ASAKGFLNIA 317

  Fly   250 GVLLQGG--ASVHMYDRSNKSPLELAEAKLRLLRNRYDHPTPETAKILEDMCMLTTLILRYMVKQ 312
            .:|::.|  |.|:..|..:..||...        :|:.|..                |::|:::.
Human   318 KLLMEEGSKADVNAQDNEDHVPLHFC--------SRFGHHD----------------IVKYLLQS 358

  Fly   313 QRELE 317
            ..|::
Human   359 DLEVQ 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10809	NP_001163403.1	Ank_2	167..263	CDD:289560	34/97 (35%)
		ANK repeat	167..193	CDD:293786	8/25 (32%)
		ANK	170..276	CDD:238125	36/107 (34%)
		ANK repeat	195..226	CDD:293786	13/30 (43%)
		ANK repeat	228..263	CDD:293786	12/36 (33%)
FPGT-TNNI3K	NP_001106279.3	ANK repeat	167..199	CDD:293786
		Ank_2	172..265	CDD:403870	18/72 (25%)
		ANK repeat	201..232	CDD:293786	9/33 (27%)
		PHA03095	221..>515	CDD:222980	48/192 (25%)
		ANK repeat	235..265	CDD:293786	8/35 (23%)
		ANK repeat	267..298	CDD:293786	13/30 (43%)
		ANK repeat	300..333	CDD:293786	12/36 (33%)
		ANK repeat	335..363	CDD:293786	7/51 (14%)
		ANK repeat	370..403	CDD:293786
		ANK repeat	405..438	CDD:293786
		ANK repeat	440..470	CDD:293786
		PKc_TNNI3K	570..823	CDD:270966
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910