Protein Alignment RasGAP1 and RASAL2

DIOPT Version :10

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: XP_016858338.1
• Gene: RASAL2 / 9462
• HGNCID: 9874
• Length: 1419
• Species: Homo sapiens
• Alignment Length: 1404
• Identity: 279/1404 - (19%)
• Similarity: 464/1404 - (33%)
• Gaps: 435/1404 - (30%)

  Fly     3 LKKKRYMFDERDD---NNINSPVAV-----EPS----SNNNKMADTREVRIEEQLKVKIGEAKNL 55
            :|.||    :::|   :|:..|:..     .||    .|..:...:.:..:.|:.:.|:...| :
Human    42 VKSKR----KKNDSAVSNLGKPLGAYRWQRHPSFRWKGNKRERLQSNKGDLVERQQQKVILPK-M 101

  Fly    56 SSRNAANTSCSTQGT-------------RDVYCTIALDQEEICRTPTIE---RTLTPFFGEEHQF 104
            .|.||::::....||             |..:.....:.|..|..|.:.   .:|.....|:..:
Human   102 VSNNASSSADEVLGTSTEKPHLVNSRSLRAPFTRSVSEPEPRCSIPFVRLWPTSLGSVESEQQGY 166

  Fly   105 KIPRRF--------RYLTIYLWDRDMKQDKPIGKIAIKREELHM-------YNHKDHWFSLRPVD 154
            .|...|        |.|.:    :....::|: :..:|....|.       |.....|.....:.
Human   167 FIRGIFSTLSNGFSRMLNL----KGESTNEPV-REDVKGPPTHRLSCGQSPYTETTTWERKYCIL 226

  Fly   155 QDSEVQGMVNVE----VAFTEAQQTQSL------------SEGIDLGQHTLRHHQNLPHHSHQQR 203
            .||::. ::|.|    |...:.|||.|.            |||            ..|.:..:..
Human   227 TDSQLV-LLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEG------------QFPEYPPEGA 278

  Fly   204 AHLNDYKENSELSNIQRASAAAASSSSAAMTLKT------RAAGLF-----GHVHHPPSQTQ--- 254
            ..|....|.|.    :|.|.:..|:|....::.|      :..|.|     |.:....||::
Human   279 TKLEVPAERSP----RRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDR 339

  Fly   255 ----HFPIINTTSTSS---DQLSNWKSHGRFVGVTIKVPACVDLAKKQGTCDPFVVCTAHYS--- 309
                ..|.:.:|...|   .:|...:||...:.....| .|:||    |..:|..|...|.|
Human   340 NTSFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTV-ECLDL----GRGEPVSVKPLHSSILG 399

  Fly   310 ----------------NKHQVTRRTK---QRKKTVDPEFD---------------------EAMY 334
                            :.:..:.|.|   ..::||.|..|                     :..|
Human   400 QDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKY 464

  Fly   335 F-DLHIDADAGSTNTTGSNKSAGSLESSANKGYSIYPVGGADLVEIVVSVWHDAH-GAMSDK-VF 396
            | :|.:| |.....||...|:.........:.:|:.|     |..|.|.::.|.. ....|| .:
Human   465 FCELCLD-DTLFARTTSKTKADNIFWGEHFEFFSLPP-----LHSITVHIYKDVEKKKKKDKNNY 523

  Fly   397 LGEVRLPMLNKQEQQAVNPSAWYYLQPRSMTHSSRSLNATPRSCATPPGTRLSVDSTIG-SLRLN 460
            :|.|.:|..:...:|.|  ..||                 |.|..||     :...|.| |:|:.
Human   524 VGLVNIPTASVTGRQFV--EKWY-----------------PVSTPTP-----NKGKTGGPSIRIK 564

  Fly   461 LNYTADHVFPLATYDDLMNLLLESVDQRPITVSAVSILGELVS--GKTEVAQPLVRLFTHTERIA 523
            ..:....:.|:..|.:....:..:.      ....|:|..::|  .|.|:|..||.:...|.|..
Human   565 SRFQTITILPMEQYKEFAEFVTSNY------TMLCSVLEPVISVRNKEELACALVHILQSTGRAK 623

  Fly   524 PIIKALADHEISHLTD-PTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEID 587
            ..:..|...|:....: ...|||.||:.:|.::|.::|.|..|||..|...:..:....:.||:|
Human   624 DFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVD 688

  Fly   588 PSKIKDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDLR-ECAGEHFPSNREVRYSV 651
            |||......:| :..||:...|..|..|..|....|:.|.::|...: :|...   ..:::...:
Human   689 PSKCSSSELID-HQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR---GKQDISERL 749

  Fly   652 VSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTVE 716
            :|..:||||..|||:.|.||:|..|..|.:||||||||:|.||:|.|.....:     |||:...
Human   750 ISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGN-----KEEYMAF 809

  Fly   717 L----------YKKFCTE--------------QHVD-----AVKHFL--EVISTPSHASSSVHPA 750
            :          .|:|..|              .::|     :|.|.|  ||:|......:|...|
Human   810 MNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQA 874

  Fly   751 AAAAT-PLEPVLLKEGLMTKYPTSRKRFGRQFKQRHFRLTTH----SLSYAKSKGKQPICDIPLQ 810
            ..|.. ||..||..   :||..|:.....:|.:    |.|.|    ::|.:.|.|.|.|.:.|..
Human   875 TVAKLGPLPRVLAD---ITKSLTNPTPIQQQLR----RFTEHNSSPNVSGSLSSGLQKIFEDPTD 932

  Fly   811 EIASVEQLKDKSFKMQNCFKIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFV 875
              :.:.:||..|  ..|..........|:||..                  :|..|.|
Human   933 --SDLHKLKSPS--QDNTDSYFRGKTLLLVQQA------------------SSQSMTY------- 968

  Fly   876 SGFYSCCGRSDENS---PGCKKVLDKTMDYFQMDLVTALDPALDLQRIHTLIMSNMSVLESL--- 934
                   ...||..   |..:.|                 ..:|||..|...:.:.||:..:
Human   969 -------SEKDERESSLPNGRSV-----------------SLMDLQDTHAAQVEHASVMLDVPIR 1009

  Fly   935 -------------LDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSPQAF---------------- 970
                         :..|...||..|:..|...||.|.........|.:|
Human  1010 LTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPK 1074

  Fly   971 AEFKRTIEKLREKAYAIDRDHRDYK----------------------------------QGITRQ 1001
            |....::|.|...:.....:..|:|                                  ..:.||
Human  1075 ASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQ 1139

  Fly  1002 LKYGSRQAPIGDDN-------------YWHMMRAAGQL-------------NQQHHQQQQHQQQQ 1040
            ...|..|....|..             :...:|:.|.:             |....:||....::
Human  1140 NSTGQAQIRKVDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRE 1204

  Fly  1041 ---------QQQQQQQLQQFQPQPVLPQMQNVRAYPYQPAT----SNMNAYCLHNMQYQ------ 1086
                     |:||.||:|.                |...||    ....|:.|:|.||:
Human  1205 SPVPKVRAIQRQQTQQVQS----------------PVDSATMSPVERTAAWVLNNGQYEEDVEET 1253

  Fly  1087 QQRLPFHQQQQQHHQQLQQQQSQFQPLRSHQLQRHNNNL 1125
            :|.|...:..:::.|::.:.:.:.: :.|.:|:.:...|
Human  1254 EQNLDEAKHAEKYEQEITKLKERLR-VSSRRLEEYERRL 1291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	27/159 (17%)
		C2B_RasA3	280..462	CDD:175977	46/228 (20%)
		RasGAP_GAP1_like	473..740	CDD:213330	83/301 (28%)
		PH_GAP1-like	763..867	CDD:269950	21/107 (20%)
		BTK	862..897	CDD:128417	7/37 (19%)
RASAL2	XP_016858338.1	PH-like	311..494	CDD:473070	34/188 (18%)
		C2_SynGAP_like	436..575	CDD:175980	33/168 (20%)
		RasGAP_DAB2IP	566..896	CDD:213338	94/347 (27%)
		DUF3498	886..1362	CDD:463427	79/483 (16%)