Protein Alignment RasGAP1 and IRA2

DIOPT Version :10

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: NP_014560.1
• Gene: IRA2 / 854073
• SGDID: S000005441
• Length: 3079
• Species: Saccharomyces cerevisiae
• Alignment Length: 792
• Identity: 155/792 - (19%)
• Similarity: 270/792 - (34%)
• Gaps: 227/792 - (28%)

  Fly   403 PMLNKQEQQAVNPSAWYYLQPRSMTHSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADH 467
            |:..:.:...:|.:....|...|.|:...||..|     .|.|...:.:.....|.:.:|...::
Yeast  1602 PVFLRHKMSVLNDNVILSLTNLSNTNVDASLQFT-----LPMGYSGNRNIRNAFLEVFINIVTNY 1661

  Fly   468 VFPLATYDDLMNL-LLESVD---QRPITVSAVSILGELVSGKTEV---AQPLVRLFTHTERIAPI 525
                .||....:| .||:.|   :..|....:|..|..|...:::   |..|:..|........:
Yeast  1662 ----RTYTAKTDLGKLEAADKFLRYTIEHPQLSSFGAAVCPASDIDAYAAGLINAFETRNATHIV 1722

  Fly   526 IKALADHEISHLTDPTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSK 590
            :..|..:||...:.||.|.|.|:..::.:....|..|..||.:||:|:|.:|:..:...||:..|
Yeast  1723 VAQLIKNEIEKSSRPTDILRRNSCATRSLSMLARSKGNEYLIRTLQPLLKKIIQNRDFFEIEKLK 1787

  Fly   591 IKDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDLRECAGEHFPSNREVRYSVVSGF 655
            .:|..| :..:.....|:..:.|:|:.|....|..|..|..::.:.|.|.||.:..:   ....|
Yeast  1788 PEDSDA-ERQIELFVKYMNELLESISNSVSYFPPPLFYICQNIYKVACEKFPDHAII---AAGSF 1848

  Fly   656 IFLRFFAPAILGP---KLFDLTTERLDAQTSRTLTLISKTIQSLGN----------LVSSRSSQQ 707
            :|||||.||::.|   .:.|::    .....||...::|.||::.|          |.|.:...:
Yeast  1849 VFLRFFCPALVSPDSENIIDIS----HLSEKRTFISLAKVIQNIANGSENFSRWPALCSQKDFLK 1909

  Fly   708 TCKE---EFTVELYKKFCTEQHVD-AVK----------HFL-------------EVISTPSHASS 745
            .|.:   .|..||.:   |::.:| .|:          .||             .|::...|...
Yeast  1910 ECSDRIFRFLAELCR---TDRTIDIQVRTDPTPIAFDYQFLHSFVYLYGLEVRRNVLNEAKHDDG 1971

  Fly   746 SV---------------------HPAAAAATPLEPVLLKEGLMTKYPTSRKRFGRQFKQRH-FRL 788
            .:                     .|....:..: |:.::|. |..||..     .:|..|| ||.
Yeast  1972 DIDGDDFYKTTFLLIDDVLGQLGQPKMEFSNEI-PIYIREH-MDDYPEL-----YEFMNRHAFRN 2029

  Fly   789 TTHSLSYAKSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVHNDRSLIVQTT---------- 843
            ...|.:|:.|          :.|..|.|.:...:..|.|     .:||.:.:.|.
Yeast  2030 IETSTAYSPS----------VHESTSSEGIPIITLTMSN-----FSDRHVDIDTVAYKFLQIYAR 2079

  Fly   844 ----------NCVEEREWFD---------------LLHKICLMNSIRMQYFHPS-AFVSGFYSCC 882
                      :|.|    ||               ||.::...|.|...||:.: .|:..:..|
Yeast  2080 IWTTKHCLIIDCTE----FDEGGLDMRKFISLVMGLLPEVAPKNCIGCYYFNVNETFMDNYGKC- 2139

  Fly   883 GRSDENSPGCKKVLDKTMDYFQMDLVTALDPALDLQRIHTLIMSN---------------MSVLE 932
                         |||...|     |::..|       |..|.||               :.||:
Yeast  2140 -------------LDKDNVY-----VSSKIP-------HYFINSNSDEGLMKSVGITGQGLKVLQ 2179

  Fly   933 SL---LDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLRE----------KA 984
            .:   |..:|.:.       ::.|...|::..:.....|...|..|.. |:|:          ..
Yeast  2180 DIRVSLHDITLYD-------EKRNRFTPVSLKIGDIYFQVLHETPRQY-KIRDMGTLFDVKFNDV 2236

  Fly   985 YAIDRDHRDYKQGIT-------------RQLKYGS-RQAPIGDDNYWHMMRAAGQLNQQHHQQQQ 1035
            |.|.|....:...||             |:|.:.| :...|....|:..:|...:....::....
Yeast  2237 YEISRIFEVHVSSITGVAAEFTVTFQDERRLIFSSPKYLEIVKMFYYAQIRLESEYEMDNNSSTS 2301

  Fly  1036 HQQQQQQQQQQQ 1047
            ......:.:||:
Yeast  2302 SPNSNNKDKQQK 2313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046
		C2B_RasA3	280..462	CDD:175977	11/58 (19%)
		RasGAP_GAP1_like	473..740	CDD:213330	74/313 (24%)
		PH_GAP1-like	763..867	CDD:269950	28/139 (20%)
		BTK	862..897	CDD:128417	6/35 (17%)
IRA2	NP_014560.1	RasGAP_Neurofibromin_like	1672..1990	CDD:213341	72/328 (22%)