Protein Alignment RasGAP1 and RASAL1

DIOPT Version :10

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: NP_001180449.1
• Gene: RASAL1 / 8437
• HGNCID: 9873
• Length: 806
• Species: Homo sapiens
• Alignment Length: 1015
• Identity: 266/1015 - (26%)
• Similarity: 418/1015 - (41%)
• Gaps: 263/1015 - (25%)

  Fly    45 LKVKIGEAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQFKIPRR 109
            |.|::.|.:.|.:::.:       |:.|.||.:.:|.|.:.||.|:.|:|.||:|||:...:|..
Human     7 LNVRVVEGRALPAKDVS-------GSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHLPLD 64

  Fly   110 FRYLTIYLWDRD-MKQDKPIGKIAIKREELHMYNHK-DHWFSLRPVDQDSEVQGMVNVEVAFTEA 172
            |..|..|:.|.| :..|..||||::.||.:...... |.|.:|..||.|:||||.:.:.|...|.
Human    65 FHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEICLSVQMLED 129

  Fly   173 QQTQSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTLKT 237
            .|.:.|                        |.|:                            |:.
Human   130 GQGRCL------------------------RCHV----------------------------LQA 142

  Fly   238 RAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKK--QGTCDP 300
            |                                                   |||.:  .||.||
Human   143 R---------------------------------------------------DLAPRDISGTSDP 156

  Fly   301 FVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLESSANKG 365
            |  ....:.::   :..|...|||..|.:||.:
Human   157 F--ARVFWGSQ---SLETSTIKKTRFPHWDEVL-------------------------------- 184

  Fly   366 YSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSAWYYLQPRSMTHSS 430
             .:..:.||. ..:.|.:|.......:|  |||.|.......|::.   |..|:.|.|
Human   185 -ELREMPGAP-SPLRVELWDWDMVGKND--FLGMVEFSPKTLQQKP---PKGWFRLLP------- 235

  Fly   431 RSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPI---TV 492
                 .||:.....|       .:|:||:.:....|.|.|...|..||.||:||| |.|.   |.
Human   236 -----FPRAEEDSGG-------NLGALRVKVRLIEDRVLPSQCYQPLMELLMESV-QGPAEEDTA 287

  Fly   493 SAVSILGELVSG--KTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSKMMD 555
            |.:::|.||..|  :.::|..||:||.........:..|...|::...||.|:||.|:|.||.|:
Human   288 SPLALLEELTLGDCRQDLATKLVKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSME 352

  Fly   556 EAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSK--------------IKDRSAVDTNLHNLQD 606
            :.|:|.|:.|||:.|:||:|::..|||..|:||.|              :.:....:|:|..|..
Human   353 QFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTG 417

  Fly   607 YVERVFEAITKSADRCPKVLCQIFHDLRECAGEHFPS---NREVRYSVVSGFIFLRFFAPAILGP 668
            |:..:.:||..|..|||..:...|..|.....|.||.   .::|:|..:|||:||||||||||.|
Human   418 YLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQQDVKYLAISGFLFLRFFAPAILTP 482

  Fly   669 KLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQ--TCKEEFTVELYKKFCTEQHVDAVK 731
            |||||..:..|.||||:|.|::|.:||:|||     .||  ..||.:...|:....  |.|..|:
Human   483 KLFDLRDQHADPQTSRSLLLLAKAVQSIGNL-----GQQLGQGKELWMAPLHPFLL--QCVSRVR 540

  Fly   732 HFLE-VISTPSHASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRK--------RFGRQFKQRHFR 787
            .||: ::.......:.| ||.|...|  ..:::||.:.|    ||        ||.  ||:|:..
Human   541 DFLDRLVDVDGDEEAGV-PARALFPP--SAIVREGYLLK----RKEEPAGLATRFA--FKKRYVW 596

  Fly   788 LTTHSLSYAKSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVHNDRSLIVQTT-----NCVE 847
            |:..:||::||...|....||:..|.:||::.:.:|::.:..::|..|.:..:.||     |..|
Human   597 LSGETLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVNE 661

  Fly   848 EREWFDLLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDK-TMDYFQMDLVTAL 911
            ..:|...|.|....|..::...||.||.|..::||.:::.::.||.:.... |:.    |....|
Human   662 LNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLG----DWSDPL 722

  Fly   912 DPALDLQRIH-TLIMSNMSVLESLLDPLTYHQSLSQTQHQQHNPLVPLATDLQKHS---PQAFAE 972
            ||..:.|.:: .|::....:...||:...                  :.|.|:..:   |:..|.
Human   723 DPDAEAQTVYRQLLLGRDQLRLKLLEDSN------------------MDTTLEADTGACPEVLAR 769

  Fly   973 FKRTIEKLREKAYAIDRDHRDYKQGITRQLKYGSRQAPIG 1012
            .:....:|.|....:||.|.:::|    |.:..:...|:|
Human   770 QRAATARLLEVLADLDRAHEEFQQ----QERGKAALGPLG 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	44/125 (35%)
		C2B_RasA3	280..462	CDD:175977	35/183 (19%)
		RasGAP_GAP1_like	473..740	CDD:213330	109/291 (37%)
		PH_GAP1-like	763..867	CDD:269950	32/116 (28%)
		BTK	862..897	CDD:128417	10/34 (29%)
RASAL1	NP_001180449.1	C2	6..126	CDD:472691	44/125 (35%)
		C2	134..255	CDD:472691	40/286 (14%)
		RasGAP_RASAL	263..550	CDD:213337	110/294 (37%)
		PH-like	554..691	CDD:473070	41/145 (28%)
		BTK	683..711	CDD:459937	9/27 (33%)