Protein Alignment RasGAP1 and rasal3

DIOPT Version :10

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: XP_005165804.1
• Gene: rasal3 / 798492
• ZFINID: ZDB-GENE-101130-3
• Length: 1124
• Species: Danio rerio
• Alignment Length: 1278
• Identity: 242/1278 - (18%)
• Similarity: 411/1278 - (32%)
• Gaps: 478/1278 - (37%)

  Fly    24 VEPSSNN--NKMADTREVRIEEQLKVKIGEAKNLSSR---------------------------- 58
            :|..::|  |||...|:...|:.     ||..:.::|
Zfish    67 LEKGASNKWNKMQSWRKALSEDP-----GEKSSTANRGGESPSKPDKPTTSRKNPFRRALSEPPG 126

  Fly    59 ----NAANTSCSTQGT-------------RDVYCTIALDQEEICRTPTIERTLTPFFGEEHQ--- 103
                ::|..|.|.|.|             |....|::    :..:.|.::.|:|     ||:
Zfish   127 SLLASSAPASSSAQATGSTVQDTTQRGKIRKYLQTVS----QRFKKPRLQSTVT-----EHEKCE 182

  Fly   104 ----FKIPRRFRYL---TIYLWD--RDMKQDKPIGKIAIKREELHMYNHKDH----WFSLR---- 151
                .:.|.|..:.   .:.:||  ....||   |:|.|.|||..|...::.    .||:.
Zfish   183 PDYVLQDPVRLSWAPPQEVPVWDISNCFLQD---GQILIPREEEPMMTVRNRASSCLFSVSLQNI 244

  Fly   152 ----------PV---------DQDSEVQGMVNVEVAFTEAQQTQSLSEGIDLGQHTLRHHQNLPH 197
                      ||         .||..|:|::
Zfish   245 SGSHAELNPDPVVPSSGTKLKGQDGGVKGLI---------------------------------- 275

  Fly   198 HSHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTLKTRAA----------GLFGHVHHPPSQ 252
               ::|...:|.:::|...|....|.||...|..::::...||          .:...||.....
Zfish   276 ---KRRLQGDDKRKSSTQLNTAGLSVAARYGSKESLSIPVSAAKSLNLSADQTTVIRPVHSSILG 337

  Fly   253 TQH-FPIINTTS------TSSDQLSNWKSHGRFVGVTIKVPACVDLAKKQGTCDPFVVCTAHYSN 310
            .:: |.:||:.:      ||:.:...|               ..||.:           ||| .|
Zfish   338 EKYCFQVINSENNHCFGCTSAAERDRW---------------IEDLRR-----------TAH-PN 375

  Fly   311 KHQVTRRTK------QRKKTVDPEFDEAMYFDLHIDADA-GSTNTTGSNKSAGSLESSANKGYSI 368
            |....|...      ...|.:.|:  :..|.::|:|... ..|::....||......:.:.|...
Zfish   376 KDNCERTENSLCLWINEAKDLPPK--KRYYCEVHLDGTLFARTSSRAVGKSVQRSSQAVDGGSGA 438

  Fly   369 YPVGGA---------------DLVEIVVSVWHDAHG--------AMSDKVF--LGEVRLPMLN-- 406
            :..||.               :|..:.....|...|        :..|...  ||.|.||:.:
Zfish   439 FGSGGTSGGCQLFWGEFFELDNLPPVTQITLHLFKGEDPKKKRHSRDDATLHPLGSVALPLADIK 503

  Fly   407 ---KQEQQAVNPSAWYYLQPRSMTHSSRSLNATPRSCATPPGTRLSVDST--IGSLRLNLNYTAD 466
               .||:       ||    |.:.:.             ||||..:.||.  ..|:|:...:...
Zfish   504 GRAYQEK-------WY----RIVAYK-------------PPGTSTAKDSVELQASIRVKAKFKNL 544

  Fly   467 HVFPLATYDDLMNLLLESVDQRPITVSAVSILGEL-----VSGKTEVAQPLVRLFTHTERIAPII 526
            .:.|:..|.:....         :||:.|.:...|     |..|.|:|..||.:.....:....:
Zfish   545 KILPIERYKEFAEY---------VTVNYVDMCSSLEPLLNVREKEELAGALVHVLQSIGKAKEFL 600

  Fly   527 KALADHEISHL-TDPTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSK 590
            ..|...|:..| .:...|||.|||.:|.:||.|:|.|..||..||...::::....:.||:||.|
Zfish   601 IDLGSAEVQRLGENEALIFRENTLATKAIDEYMKLVGQKYLIDTLGDFIARLYNGGENCEVDPLK 665

  Fly   591 IKDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHD-LRECAGEHFPSNREVRYSVVSG 654
            ... |.:..|..:|::..|.|.:.||...:..|..|..||.. :.:|...   ..:::...::|.
Zfish   666 CSP-SDLPINQRHLKETCEDVVKRITDMQESFPAELNDIFSSWVSDCEDR---GQQDIGQRLISA 726

  Fly   655 FIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTVELYK 719
            .:||||..||||.|.||.||....:..|.|||||.:|.||:|.|......     |||: :....
Zfish   727 SLFLRFLCPAILSPSLFGLTQPYPETNTLRTLTLTAKVIQNLANFTLFGE-----KEEY-MFFMN 785

  Fly   720 KFCTEQHVDAVKHFLEVISTPSHASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRKRFGRQFKQR 784
            .|.| ||.:.::.||:.:|.|.                     .|..|:::.
Zfish   786 DFLT-QHWEPMRDFLQKVSNPE---------------------SEITMSRFD------------- 815

  Fly   785 HFRLTTHSLSYAKSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVHNDRSLIVQTTNCVEER 849
                     .|.         |:||:                  ..::||   |:|..
Zfish   816 ---------GYV---------DLPLR------------------LAVLHN---LLVDI------- 834

  Fly   850 EWFDLLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQMDLVTALDPA 914
                    |.:|...::...||                    ..::|::..::.          .
Zfish   835 --------ISVMKQDQIDNLHP--------------------LPRILNQITEFL----------G 861

  Fly   915 LDLQRIHTLIMSNMSVLESLLDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSP------QAFAEF 973
            .|.|:|                |::.:|::.:       |:.....||.|:||      |...:.
Zfish   862 HDAQQI----------------PVSSNQAMPK-------PIYVPPRDLPKYSPLQTSMQQLPIDS 903

  Fly   974 KR---TIEKLR---EKAYAI-DRDHRDYKQGITRQLKYGSRQAPIGDDNYWHMMRAAGQLNQQ-- 1029
            |.   |.|:.|   ::|::: :|..|..:|.:.||...........|||..|.:..:...|.:
Zfish   904 KPNQCTKERQRRQVQRAFSVPNRPSRQQRQPMKRQASNEELPTQCPDDNQDHRLEISPPSNPEKS 968

  Fly  1030 --------HHQQQQHQQQQQQQQQQQLQQFQPQPVLPQMQNVRAYPYQPATSNMNAYCLHNMQYQ 1086
                    |..:|....:..|.::|..::                        .|....|..:..
Zfish   969 KAAAAAKVHWIKQPDGSETCQVRRQDREE------------------------TNTLDKHAQELS 1009

  Fly  1087 QQRLPFHQQQQQH--------------HQQLQQQQSQFQPLRS 1115
            :.|:...|..::.              ..|..|.|::.|.||:
Zfish  1010 ELRMGVEQVTERELEMAKRLEDFIVLTQDQNAQLQAEVQDLRN 1052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	36/208 (17%)
		C2B_RasA3	280..462	CDD:175977	41/220 (19%)
		RasGAP_GAP1_like	473..740	CDD:213330	82/273 (30%)
		PH_GAP1-like	763..867	CDD:269950	12/103 (12%)
		BTK	862..897	CDD:128417	2/34 (6%)
rasal3	XP_005165804.1	PH_RasSynGAP-like	256..382	CDD:270082	30/189 (16%)
		C2_SynGAP_like	374..549	CDD:175980	36/200 (18%)
		RasGAP_DAB2IP	540..862	CDD:213338	99/459 (22%)
		Myosin_tail_1	1003..>1068	CDD:460256	9/50 (18%)