Protein Alignment RasGAP1 and rasal2

DIOPT Version :10

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: XP_005171378.1
• Gene: rasal2 / 793730
• ZFINID: ZDB-GENE-070912-180
• Length: 1432
• Species: Danio rerio
• Alignment Length: 940
• Identity: 208/940 - (22%)
• Similarity: 326/940 - (34%)
• Gaps: 273/940 - (29%)

  Fly   322 KKTVDPEFD---------------------EAMYF-DLHIDADAGSTNTTGSNKS-----AGSLE 359
            |:||.|..|                     :..|| :|.:| |.....||...:|     ....|
Zfish   414 KRTVQPNKDNCRRAENVLRLWIIEAKDLPPKKKYFCELCLD-DMLYARTTSKTRSDCLFWGEHFE 477

  Fly   360 SSANKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKV-------FLGEVRLPMLNKQEQQAVNPSA 417
            .|          |...:..|.:.::.|.     ||.       ::|.|.:|:.....:|.|  ..
Zfish   478 FS----------GLPSMKSITIHIYRDV-----DKKKKKDKNNYVGLVNIPVHGVMGRQFV--EK 525

  Fly   418 WYYLQPRSMTHSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLL 482
            ||   |.|...:|::....|                  |:|:...:....:.|:..|.:....:.
Zfish   526 WY---PVSTPTTSKAKGGGP------------------SIRIKSRFQTISILPMEQYKEFAEFVT 569

  Fly   483 ESVDQRPITVSAVSILGELVS--GKTEVAQPLVRLFTHTERIAPIIKALADHEISHLTD-PTTIF 544
            .:.      ....|:|..::|  .|.|:|..||.:...|.|....:..|...|:....| ...||
Zfish   570 NNY------TMLCSVLEPVISVKNKEEMASALVHILQSTGRAKDFLTDLVMSEVDRCADHDVLIF 628

  Fly   545 RGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYVE 609
            |.|||.:|.::|.::|.|..|||..|...:..:....:.||:|.||... :.:..:..||:...|
Zfish   629 RENTLATKAIEEYLKLVGQKYLHDALGEFIKALYESDENCEVDQSKCTS-NELPEHQSNLKMCCE 692

  Fly   610 RVFEAITKSADRCPKVLCQIFHDLR-ECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDL 673
            ..|..|..|....|:.|.::|...: :|   |....:::...::|..:||||..|||:.|.||.|
Zfish   693 LAFCKIINSYCVFPRELKEVFASWKQQC---HARGKQDISQRLISASLFLRFLCPAIMSPSLFGL 754

  Fly   674 TTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFLEV-- 736
            ..|..|.:||||||||:|.||:|.|.....:     |||: :.....|...:.....:..||:
Zfish   755 MQEYPDDRTSRTLTLIAKVIQNLANFAKFGN-----KEEY-MAFMNDFLEHEWAGMTRFLLEISN 813

  Fly   737 ISTPSHASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRKRFGRQFKQRHFRLTTHSLSYAKSKGK 801
            :.|.|:....                 ||.:.        .||:..      ..|||
Zfish   814 LETISNTPGF-----------------EGYID--------LGRELS------VLHSL-------- 839

  Fly   802 QPICDIPLQEIASVEQLKDKSFKMQNCFKI-----VHND--RSLIVQTTNCVEEREWFDLLHKIC 859
                   |.|:.|.....|.||......|:     :..|  |||...|.
Zfish   840 -------LWEVVSQLDKGDNSFLQATVAKLGPLPRILGDITRSLSSPTP---------------- 881

  Fly   860 LMNSIRMQYFHPSAF-VSGFYSCCGRSDENSPGCKKVLDKTMDYFQMDLVTALDPA-LDLQRIHT 922
            :...:|....|.||. :||         ..|.|.:::.:              ||| .:::.|.:
Zfish   882 IQQQLRRFQDHSSAHDISG---------SVSSGLQRIFE--------------DPADSEMRSIKS 923

  Fly   923 LIMSNMSVLESLLDPLTYHQSLSQT-----QHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLRE 982
            .:..:|..|.....||...||.:.:     :.::.:||           |..     |:|..:..
Zfish   924 PVQEHMEALVRGKHPLLGQQSSAHSMSFSDKEERDSPL-----------PNG-----RSISLMDL 972

  Fly   983 KAYAIDRDH---RDYKQGITRQLKYGSRQAPIGDDNYWHMMRAAGQLNQQHHQQQQHQQQQQQQQ 1044
            :...:.:.|   ....:..:|..:.|| ||.||.....|:           ||...|  .:..|.
Zfish   973 QDSYLAQGHPGPNSLNEASSRLGRVGS-QASIGPVPPPHL-----------HQPPVH--PKVPQL 1023

  Fly  1045 QQQLQQFQPQ---PVLPQMQNVRAYPYQPATSNMNAYCLHNMQYQQQRLPFHQQQQQHHQQLQQQ 1106
            :..|.|..||   |:.|.:...|:  .||.:.....|.|.|:..|..    |..|..|..|..|.
Zfish  1024 RDNLPQSAPQVRRPIHPSLSQQRS--LQPLSFQNPVYHLSNLHAQST----HSTQSTHSAQSLQP 1082

  Fly  1107 QSQFQPLRSHQLQRHNNNLNNNNCGNGSSSSPSST---TSSVVAAPPSTTS----------SSQP 1158
            .|..:               |.:.|:..|:|||::   .::..|..|||:|          ..|.
Zfish  1083 DSSSE---------------NLSTGSSRSASPSASGGRGATPRARIPSTSSVEEEFSRRSIQGQE 1132

  Fly  1159 APPIYXR---------SRLCVFALPRAIIT 1179
            .||...|         |...|.|:||...|
Zfish  1133 TPPPTARWHPPLADQHSGAQVVAVPRQSTT 1162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046
		C2B_RasA3	280..462	CDD:175977	33/173 (19%)
		RasGAP_GAP1_like	473..740	CDD:213330	77/272 (28%)
		PH_GAP1-like	763..867	CDD:269950	20/110 (18%)
		BTK	862..897	CDD:128417	8/35 (23%)
rasal2	XP_005171378.1	PH-like	293..477	CDD:473070	13/63 (21%)
		C2_SynGAP_like	419..558	CDD:175980	30/177 (17%)
		RasGAP_DAB2IP	549..879	CDD:213338	98/391 (25%)
		DUF3498	869..1402	CDD:463427	81/384 (21%)