Protein Alignment RasGAP1 and Rasa4

DIOPT Version :10

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: NP_598675.2
• Gene: Rasa4 / 54153
• MGIID: 1858600
• Length: 802
• Species: Mus musculus
• Alignment Length: 975
• Identity: 242/975 - (24%)
• Similarity: 389/975 - (39%)
• Gaps: 238/975 - (24%)

  Fly    45 LKVKIGEAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQFKIPRR 109
            |.::|.|.|||.:::..       |:.|.||.:.:|.|.|.||.|:.:||.||:||::|..:|..
Mouse     7 LSIRIVEGKNLPAKDIT-------GSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEDYQVHLPPT 64

  Fly   110 FRYLTIYLWDRD-MKQDKPIGKIAIKREELHMYNHK---DHWFSLRPVDQDSEVQGMVNVEVAFT 170
            |..:..|:.|.| :.:|..|||:.:.|:.|  .:|.   ..|..|..||.:.||||.:::.:...
Mouse    65 FHTVAFYVMDEDALSRDDVIGKVCLTRDAL--ASHPKGFSGWTHLVEVDPNEEVQGEIHLRLEVV 127

  Fly   171 EAQQTQSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTL 235
            .             |.|                                       :|......|
Mouse   128 P-------------GVH---------------------------------------ASRLRCAVL 140

  Fly   236 KTRAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKK--QGTC 298
            :.|                                                   |||.|  .|..
Mouse   141 EAR---------------------------------------------------DLAPKDRNGAS 154

  Fly   299 DPFVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLESSAN 363
            ||||  ..||:.:   |:.|...||:..|.::|...|:                     ||..|:
Mouse   155 DPFV--RVHYNGR---TQETSVVKKSCYPRWNETFDFE---------------------LEKGAS 193

  Fly   364 KGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQ-QAVNPSAWYYLQPRSMT 427
            :.             ::|..|.  ...:|...|||:|   .:|.|.. .|.....|:.|||
Mouse   194 EA-------------LLVEAWD--WDLVSRNDFLGKV---AVNVQRLCSAQQEEGWFRLQP---- 236

  Fly   428 HSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESV---DQRP 489
            ..|:|...               ...:|||:|.:....:.|.|...|..|:.||.:.|   .|.|
Mouse   237 DQSKSRQG---------------KGNLGSLQLEVRLRDETVLPSVCYQPLVQLLCQEVKLGTQGP 286

  Fly   490 ITVSAVSILGELVSG--KTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSK 552
            ..:  :.::.|..|.  :.|||..|::||.........:..|...|:...::..|:||.|:|.||
Mouse   287 GRL--IPVIEETTSAECRQEVATTLLKLFLGQGLAKDFLDLLFQLELGRTSEANTLFRSNSLASK 349

  Fly   553 MMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLH--------------N 603
            .|:..::::|:.|||..|.|::.::..|||..|:||||::.:....:.||              .
Mouse   350 SMESFLKVAGMRYLHGILGPIIDRVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQT 414

  Fly   604 LQDYVERVFEAITKSADRCPKVLCQIFHDLRECAGEHFPS--NREVRYSVVSGFIFLRFFAPAIL 666
            |:.::..:..||.:|...||.::...|..|.....|.||:  ::.|.:..|:.|:.||||:||||
Mouse   415 LRAHLVALLSAICRSVRTCPAIIRATFRQLFRRVRERFPNAQHQNVPFIAVTSFLCLRFFSPAIL 479

  Fly   667 GPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTVELYKKFCTEQHVDAVK 731
            .||||.|.....||:|||||.|::|.:|::||:.:..|   ..||.:...|..  ...|.|..:|
Mouse   480 SPKLFHLRERHADARTSRTLLLLAKAVQNIGNMDTPVS---RAKESWMEPLQP--TVRQGVAQLK 539

  Fly   732 HF-LEVISTPSHASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRK--RFGRQFKQRHFRLTTHSL 793
            .| ::::.........:..|..:..|  ||  |||.:..:.|..|  .....||:.:|.|||.:|
Mouse   540 DFIMKLVDIEEKEELDLQRALNSQAP--PV--KEGPLFIHRTKGKGPLASSSFKKLYFSLTTEAL 600

  Fly   794 SYAKSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVHNDRSLIVQTT----NCVEE-REWFD 853
            |:||:...:....|.|..|.:.|::::|||...:..::::.|.....||.    .||.| .:|..
Mouse   601 SFAKTSSSKKSTFIKLASIRAAEKVEEKSFGSSHIMQVIYADDVGRAQTVYLQCKCVNELNQWLS 665

  Fly   854 LLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQM-DLVTALDPALDL 917
            .|.|....|...::.:||..|....:|||.:.|:...||    |||.....: :....||..|:.
Mouse   666 ALRKASTNNRGLLRSYHPGIFRGDKWSCCHQKDKTDQGC----DKTHSRVTLQEWNDPLDHDLEA 726

  Fly   918 QRIHTLIMSNMSVLESLLDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLRE 982
            |.|:..::...:.|..      .:|.|........:|     |........:.|:..|.::.|||
Mouse   727 QLIYRHLLGVEAALRE------RYQLLRGATEAGVSP-----TGCDGAPEDSLAQLLRVLQDLRE 780

  Fly   983  982
            Mouse   781  780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	43/127 (34%)
		C2B_RasA3	280..462	CDD:175977	41/184 (22%)
		RasGAP_GAP1_like	473..740	CDD:213330	88/288 (31%)
		PH_GAP1-like	763..867	CDD:269950	32/110 (29%)
		BTK	862..897	CDD:128417	10/34 (29%)
Rasa4	NP_598675.2	C2A_Rasal1_RasA4	6..126	CDD:176018	43/127 (34%)
		C2	134..256	CDD:472691	43/235 (18%)
		RasGAP_RASA4	264..549	CDD:213343	89/291 (31%)
		PH_CAPRI	541..680	CDD:241523	37/142 (26%)
		BTK	680..709	CDD:459937	12/32 (38%)