Protein Alignment RasGAP1 and Rasal1

DIOPT Version :10

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: NP_001101805.1
• Gene: Rasal1 / 360814
• RGDID: 1311820
• Length: 801
• Species: Rattus norvegicus
• Alignment Length: 990
• Identity: 270/990 - (27%)
• Similarity: 414/990 - (41%)
• Gaps: 256/990 - (25%)

  Fly    45 LKVKIGEAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQFKIPRR 109
            |.:::.|.:.|.:::.:       |:.|.||.:.:|.|.:.||.||.|:|:||:|||:...:|..
  Rat     7 LSIRVVEGRALPAKDVS-------GSSDPYCLVKVDDEVVARTATIWRSLSPFWGEEYTVHLPLD 64

  Fly   110 FRYLTIYLWDRD-MKQDKPIGKIAIKREELHMYNHK-DHWFSLRPVDQDSEVQGMVNVEVAFTEA 172
            |.:|..|:.|.| :..|..||||::.:|.:...... |.|.:|..||.|.||||.|.:.|...|.
  Rat    65 FHHLAFYVLDEDTVGHDDIIGKISLSKEAITADPRGIDSWINLSRVDPDEEVQGEVCLAVKLLED 129

  Fly   173 QQTQSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTLKT 237
            .:.:.|                        |.|:...:
  Rat   130 ARGRCL------------------------RCHVRQAR--------------------------- 143

  Fly   238 RAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKK--QGTCDP 300
                                                                |||.:  .||.||
  Rat   144 ----------------------------------------------------DLAPRDISGTSDP 156

  Fly   301 FVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLESSANKG 365
            |  ....:.::   :..|...|||..|.:||.    |.:....|:|:
  Rat   157 F--ARVFWGSR---SLETSTIKKTRFPHWDEV----LELREAPGTTS------------------ 194

  Fly   366 YSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSAWYYLQPRSMTHSS 430
                        .:.|.:|.......:|  |||.|.   ...|..|...|:.|:.|.|......|
  Rat   195 ------------PLRVELWDWDMVGKND--FLGMVE---FTPQTLQQKPPNGWFRLLPFPRAEDS 242

  Fly   431 RSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPI---TV 492
                                ..::|:|||.:..|.|.|.|...|..||.|||||| |.|.   |.
  Rat   243 --------------------GGSLGALRLKVRLTEDRVLPSQYYQPLMELLLESV-QGPAEEDTT 286

  Fly   493 SAVSILGELVSG--KTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSKMMD 555
            |.:::|.||.||  :.::|..||:||.......|.:..|...|::...||.|:||.|:|.||.|:
  Rat   287 SPLALLEELASGDCRQDLATKLVKLFLGRGLAGPFLDYLTRREVARTNDPNTLFRSNSLASKSME 351

  Fly   556 EAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKI--------------KDRSAVDTNLHNLQD 606
            :.|:|.|:.|||:.||||:|::..|||..|:||||:              .:....:|:|..|..
  Rat   352 QFMKLVGMRYLHEVLRPVISRVFEEKKYMELDPSKMDLNRSRRISFKGTPTEEQVRETSLGLLTG 416

  Fly   607 YVERVFEAITKSADRCPKVLCQIFHDLRECAGEHFP--SNREVRYSVVSGFIFLRFFAPAILGPK 669
            |:..|.:||..||.|||..|...|..|::|..:.||  .:::|:|...|||:||||||||||.||
  Rat   417 YLGSVVDAIVSSAGRCPLALRLAFKQLQQCVEKRFPGMEHQDVKYLATSGFLFLRFFAPAILTPK 481

  Fly   670 LFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQ--TCKEEFTVELYKKFCTEQHVDAVKH 732
            ||||.....|.||||:|.|::|.:||:|||     .||  ..||::...|:....  |.:..|:.
  Rat   482 LFDLRDHHADPQTSRSLLLLAKAVQSIGNL-----GQQLGQGKEQWLAPLHPFLL--QSISRVRD 539

  Fly   733 FLEVISTPSHASSSVHPAAAAATPLEPVLLKEGLMTK---YPTS-RKRFGRQFKQRHFRLTTHSL 793
            ||:.:........:.....|...|  ..:::||.:.|   .|.| ..||.  ||:|:|||:...|
  Rat   540 FLDQLVDVDGDEEAGGSTCALVQP--STIVREGFLLKRKEEPASLATRFA--FKKRYFRLSGRDL 600

  Fly   794 SYAKSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVHND-----RSLIVQTTNCVEEREWFD 853
            ||:|:...|....|||..|.:||::.:.:|::.:..::|..|     .:..:|..|..:..:|..
  Rat   601 SYSKTPEWQVHSSIPLSCIRAVERVDEGAFQLPHVMQVVTQDGTGASHTTYLQCKNVNDLNQWLS 665

  Fly   854 LLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDK-TMDYFQMDLVTALDPALDL 917
            .|.|....|..::...||.||.||.::||.:::.::.||.:.... |:.    |....|||..:.
  Rat   666 ALRKASAPNPGKLAACHPGAFRSGRWTCCLQAERSAVGCSRTHSAVTLG----DWSDPLDPDAEA 726

  Fly   918 QRIHTLIMSNMSVL------ESLLD----------------PLTYHQSLSQTQHQQHNPLVPLAT 960
            |.::..::.....|      :|.||                |..  :.|:| |.:....|:.:..
  Rat   727 QMVYRQLLLGRDQLRLKLLEDSSLDTAPDVDPGKDSSAVDGPCA--EVLAQ-QREATTRLLQVLE 788

  Fly   961 DLQKHSPQAFAEFKR 975
            ||:    ||..||::
  Rat   789 DLE----QAHEEFQK 799

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	44/125 (35%)
		C2B_RasA3	280..462	CDD:175977	36/183 (20%)
		RasGAP_GAP1_like	473..740	CDD:213330	116/289 (40%)
		PH_GAP1-like	763..867	CDD:269950	33/112 (29%)
		BTK	862..897	CDD:128417	11/34 (32%)
Rasal1	NP_001101805.1	C2	6..126	CDD:472691	44/125 (35%)
		C2	134..254	CDD:472691	39/286 (14%)
		RasGAP_RASAL	262..548	CDD:213337	117/293 (40%)
		PH-like	552..689	CDD:473070	39/140 (28%)
		BTK	681..709	CDD:459937	10/27 (37%)