Protein Alignment RasGAP1 and raskol

DIOPT Version :10

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: NP_001285388.1
• Gene: raskol / 32754
• FlyBaseID: FBgn0261570
• Length: 2016
• Species: Drosophila melanogaster
• Alignment Length: 1139
• Identity: 244/1139 - (21%)
• Similarity: 407/1139 - (35%)
• Gaps: 334/1139 - (29%)

  Fly   118 WDRDMKQDKPIGKIAIKREELHMYNHKDHW-------FSLRPVDQDSEVQGMVNVEVAFTEAQQT 175
            |.:...|  |.....:..:||:.|...|..       |.:|.:.........:..:::.|...:|
  Fly   507 WGKHFYQ--PYDVCPLSLDELNCYFQADQCEKLICERFKIRDLAIHMASASAIGADLSVTTENET 569

  Fly   176 QSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTLKTRAA 240
            .:.::. |.|     ||.:.   |:::............|.:.|..:...|:|         |..
  Fly   570 TATADD-DAG-----HHSDT---SYEKACRRGSAPTTPILGSKQHQTEHNATS---------RFT 616

  Fly   241 GLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKKQGTCDPFV-VC 304
            ..|....:|..:|:....:..|...|..|...:||...:. :..|.:.:||     :|...| |.
  Fly   617 NFFSKKSNPLKRTKSVTKLERTKRGSGGLRGSRSHESLLS-SHAVMSTIDL-----SCTGAVGVA 675

  Fly   305 TAHYS---NKH--QV-----------------------------------TRRTKQ-------RK 322
            ..|.|   .:|  ||                                   ||||..       ..
  Fly   676 PVHQSVLGRRHCFQVRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEA 740

  Fly   323 KTVDPEFDEAMYF-DLHIDADAGSTNTTGSNKSAGSLESSA---NKGYSIYPVGGADLVE---IV 380
            |.:.|   :..|| :|.:|       .|...:::..|::..   .:.:. :|    |:.|   |.
  Fly   741 KNLPP---KKRYFCELQLD-------KTLYGRTSVKLQTDLLFWGEHFD-FP----DIPEINVIT 790

  Fly   381 VSVWHDAHGAMS-DKV-FLGEVRLPMLNKQEQQAVNPSAWYYLQPRSMTHSSRSLNATPRSCATP 443
            |:|:.:...... ||. |:|.|::|:.:...:  :....||   |.....:..||..|    :..
  Fly   791 VNVFREVDKKKKRDKYQFVGSVKIPVHDVTSR--LPCEQWY---PILSDKAGDSLGRT----SGG 846

  Fly   444 PGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPITVSAVSILGELVSGKTEV 508
            .|:.......:.:||:...:.:..:.|:..|.:.:..|.|  :.:.:..:...::|  |..|.::
  Fly   847 GGSGSKDKEQLPTLRIKCRFQSTDILPINVYGNFLTYLKE--NYKRVCETLEPVIG--VKAKEDI 907

  Fly   509 AQPLVRLFTHTERIA-PIIKALADHEISHLTDPTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRP 572
            .|.|| |..|.:.:| ..:..:...::..:.|....||||:|.:|.|:..::|:|..||..||..
  Fly   908 GQALV-LLMHAQGLAGAFLTDVVALDLLRVGDQRLTFRGNSLATKSMEAFLKLTGEQYLQDTLSA 971

  Fly   573 VLSQIVAEKKPCEIDPSKIKDRSA--VDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDLRE 635
            .:::::..::.||:||:|....||  :......|:..|...::.|.:|....|..|...|...||
  Fly   972 PINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQCIFESHKHFPAQLRNCFATFRE 1036

  Fly   636 CAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLV 700
            ...:  ...:::..:::|..|||||..||||.|.||::|:|...|:.:|.|||::||:|:|.|..
  Fly  1037 RLQQ--LGRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARATRNLTLVAKTLQTLANFT 1099

  Fly   701 SSRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFLEVISTPSHASSSVHPAAAAATPLEPVLLKEG 765
            ..:.     ||.| :|....| .||....::.|||:|||...     |||.      :.:|...|
  Fly  1100 RFQG-----KENF-MEFLNDF-LEQEAARMQQFLEIISTRPE-----HPAP------DSILDWAG 1146

  Fly   766 LMTKYPTSRKRFGRQFKQRHFRLTTHSLSYAK-SKGKQPICDIPLQEIASVEQLKDKSFKMQNCF 829
            .:.:        |:|....|..|   |.|.|| .:.:|...| |||.|
  Fly  1147 YIDQ--------GKQLSILHSLL---SESLAKLPEARQHELD-PLQHI----------------- 1182

  Fly   830 KIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFV---SGFYSCCGRSDEN-SP 890
                                     |.:|.......|....|..::   |..:|....:.|| :|
  Fly  1183 -------------------------LDEISRAKEHGMGTALPGGYLPATSSTHSIASENQENRNP 1222

  Fly   891 G---------CKKVLDKTMDYFQMDLVTALDPALDLQRIHTLIMSNMSVLESLLDPLTYHQSLSQ 946
            |         .:::|.:     |..|.         |..|.::...:|....::..:....||.:
  Fly  1223 GSSGSHAGSNSEQLLPQ-----QSQLA---------QPQHAIVSKPLSAERGIMRGVLTPNSLEK 1273

  Fly   947 TQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLREKAYAIDRDHRDYKQGITRQLKYGSRQAPI 1011
            ...:.::|.|
  Fly  1274 NIFRYNDPTV------------------------------------------------------- 1283

  Fly  1012 GDDNYWHMMRAAGQLNQQHHQQQQHQQQQQQQQQQQLQQ--FQPQP----VLPQMQNVRA----- 1065
                       .|.|.||  ||||.||||||||.|||||  .|.||    .|..:.|.:.
  Fly  1284 -----------NGLLQQQ--QQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQMLSNSQTSIAGN 1335

  Fly  1066 -YPYQP------------ATSNMN---AYCLHNMQYQQQRLPFHQQQQQHHQQLQQQQSQFQPLR 1114
             |...|            |:|::|   :..||.          |||...|.|||........|..
  Fly  1336 QYMSSPGGLQHAQSQTSMASSSLNGSSSNLLHG----------HQQHAHHPQQLHPHHCPPAPQT 1390

  Fly  1115 S-----HQLQRHNNNLNNNNCGNGSSSSPSSTTS 1143
            |     .::.|.|....::|..:..:|:||||.|
  Fly  1391 SASSTMERMDRMNYPYMSHNGNDYETSTPSSTRS 1424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	9/57 (16%)
		C2B_RasA3	280..462	CDD:175977	44/238 (18%)
		RasGAP_GAP1_like	473..740	CDD:213330	79/269 (29%)
		PH_GAP1-like	763..867	CDD:269950	17/104 (16%)
		BTK	862..897	CDD:128417	8/47 (17%)
raskol	NP_001285388.1	PH_RasSynGAP-like	615..729	CDD:270082	21/119 (18%)
		C2_SynGAP_like	721..874	CDD:175980	33/176 (19%)
		RasGAP_DAB2IP	865..1192	CDD:213338	102/405 (25%)
		DUF3498	<1927..1997	CDD:463427