Protein Alignment RasGAP1 and Rasal3

DIOPT Version :10

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: NP_001401865.1
• Gene: Rasal3 / 314596
• RGDID: 1309019
• Length: 1038
• Species: Rattus norvegicus
• Alignment Length: 639
• Identity: 146/639 - (22%)
• Similarity: 217/639 - (33%)
• Gaps: 199/639 - (31%)

  Fly   238 RAAGLFGHVHHPPSQTQHFPIIN---------------------------TTSTSSDQ--LSNWK 273
            |||    |:..||:  ...|:.|                           .:|.||.|  |.|.|
  Rat   141 RAA----HIPEPPA--PDMPVWNIDGFALLEGRLVMLGEEEGPRQIRMGSASSESSMQAALGNLK 199

  Fly   274 SHGRFVGVTIKVPACVDLAKKQGTCDPFVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLH 338
                            |..:..|..:|....:....|..::.:|.|::|:.
  Rat   200 ----------------DPVRTPGKIEPEATGSNQVHNVRKLLKRLKEKKRA-------------- 234

  Fly   339 IDADAGS-TNTTGSNKSAGSLESSANKGYSIYPVGGADL-VEIVVSVWHDAHGAMSDKVFLGEVR 401
             .::.|: |...|.:.:.||.||.|.       :...|| ||..|.|| ..|.::..:.:..:|.
  Rat   235 -KSELGAHTPRDGPSSALGSRESLAT-------LSELDLGVERDVRVW-PLHPSLLGEPYCFQVT 290

  Fly   402 ---------------------------LPMLNKQEQQAVNPSAWYYLQ---PRSMTHSSRS---- 432
                                       .|..:..|:|....:.|.:..   ||:.....|:
  Rat   291 WAGGSRCFSCRSSAERDRWIEDLRRQFQPSQDNVERQETWLTVWVHEAKGLPRAAAPGVRAELWL 355

  Fly   433 -----LNATPRSC-------------ATPPGTRLSV--------DSTIGS--------------- 456
                 ....||:.             |.||..|||:        .:|:|.
  Rat   356 DGALLARTAPRAGPDQLFWAERFHFEALPPARRLSLRLRGAGPAGATVGRVVLELDEVSIPRAPA 420

  Fly   457 -----------------LRLNLNYTADHVFPLATYDDLMNLLLESVDQRPITVS-AVSILGELVS 503
                             ||..:......|.|...|.:|...|.....:..:.:. |:|     ..
  Rat   421 AGLERWFPVLGAPAGAVLRARIRVRCLRVLPSERYKELAEFLTFHYARLCMALEPALS-----AQ 480

  Fly   504 GKTEVAQPLVRLFTHTERIAPIIKALADHEISHLTD-PTTIFRGNTLVSKMMDEAMRLSGLHYLH 567
            .|.|:|..:||:...|.|...::..|...|:..... ...:||.|||.:|.:||.|:|....||.
  Rat   481 AKEELAAAMVRVLRATGRAQALVTDLGTAELERCGGREALLFRENTLATKAIDEYMKLVAQEYLQ 545

  Fly   568 QTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHD 632
            :||..|:..:.|..:.||:||||........... .|:...|.|||.|..|.:..|..|..:|.:
  Rat   546 ETLGQVVRSLCASTEDCEVDPSKCPTPELPKCQA-RLRSSCEEVFENIIHSYNYFPAELGTVFSN 609

  Fly   633 LRE-CAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSL 696
            .|| |...   .:..:...:|...:|||...||||.|.||.|..|......:||||||:|.||:|
  Rat   610 WREACKAR---GSEALGPRLVCASLFLRLLCPAILAPSLFGLAPEHPAPGPARTLTLIAKVIQNL 671

  Fly   697 GNLVSSRSSQQTCKEEFTVELYKKFCT---EQHVDAVKHFLEVI------STPS 741
            .|          |......|.|..|..   |.|..|::|||:.:      :|||
  Rat   672 AN----------CAPFGEKEAYMVFMNSFLEDHGPAMRHFLDQVAMVDTDTTPS 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046
		C2B_RasA3	280..462	CDD:175977	43/275 (16%)
		RasGAP_GAP1_like	473..740	CDD:213330	83/278 (30%)
		PH_GAP1-like	763..867	CDD:269950
		BTK	862..897	CDD:128417
Rasal3	NP_001401865.1	PH-like	200..346	CDD:473070	30/168 (18%)
		C2	319..451	CDD:472691	20/131 (15%)
		RasGAP_DAB2IP	443..766	CDD:213338	88/292 (30%)