Protein Alignment RasGAP1 and Rasal2

DIOPT Version :10

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: XP_006496813.1
• Gene: Rasal2 / 226525
• MGIID: 2443881
• Length: 1289
• Species: Mus musculus
• Alignment Length: 1203
• Identity: 246/1203 - (20%)
• Similarity: 401/1203 - (33%)
• Gaps: 380/1203 - (31%)

  Fly   154 DQDSEVQGMVNVEVAFTEAQQTQSL------------SEGIDLGQHTLRHHQNLPHHSHQQRAHL 206
            :::..|:|         :.|||.|.            |||            ..|.:..:....|
Mouse   108 EKEMPVEG---------QDQQTDSTKGRCLRRTVSVPSEG------------QFPEYPQEGTTKL 151

  Fly   207 NDYKENSELSNIQRASAAAASSSSAAMTLKT------RAAGLF-----GHVHHPPSQTQ------ 254
            ....|.|.    :|.|.:..|:|....::.|      :..|.|     |.:....||::
Mouse   152 EVPAERSP----RRRSISGTSTSEKPNSMDTANTSPFKVPGFFSKRLKGSIKRTKSQSKLDRNTS 212

  Fly   255 -HFPIINTTSTSS---DQLSNWKSHGRFVGVTIKVPACVDLAKKQGTCDPFVVCTAHYSNKHQ-- 313
             ..|.:......|   .:|...:||...:.....| .|:||    |..:|..|...|.|...|
Mouse   213 FRLPSLRNADDRSRGLPKLKESRSHESLLSPCSAV-ECLDL----GRGEPVSVKPLHSSILGQDF 272

  Fly   314 -----------------VTRRTK---QRKKTVDPEFD---------------------EAMYF-D 336
                             .:.|.|   ..::||.|..|                     :..|| :
Mouse   273 CFEVTYLSGSKCFSCSSASERDKWMENLRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCE 337

  Fly   337 LHIDADAGSTNTTGSNKSAGSLESSANKGYSIYPVGGADLVEIVVSVWHDAH-GAMSDK-VFLGE 399
            |.:| |.....||...|:.........:.||:.|     |..|.|.::.|.. ....|| .::|.
Mouse   338 LCLD-DTLFARTTSKTKADNIFWGEHFEFYSLPP-----LHSITVHIYKDVEKKKKKDKNNYVGL 396

  Fly   400 VRLPMLNKQEQQAVNPSAWYYLQPRSMTHSSRSLNATPRSCATPPGTRLSVDSTIG-SLRLNLNY 463
            |.:|..:...:|.|  ..||                 |.|..||     :...|.| |:|:...:
Mouse   397 VNIPTASVTGRQFV--EKWY-----------------PVSTPTP-----NKGKTGGPSIRIKSRF 437

  Fly   464 TADHVFPLATYDDLMNLLLESVDQRPITVSAVSILGELVS--GKTEVAQPLVRLFTHTERIAPII 526
            ....:.|:..|.:....:..:.      ....|:|..::|  .|.|:|..||.:...|.|....:
Mouse   438 QTITILPMEQYKEFAEFITSNY------TMLCSVLEPVISVRNKEELACALVHILQSTGRAKDFL 496

  Fly   527 KALADHEISHLTD-PTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSK 590
            ..|...|:....: ...|||.||:.:|.::|.::|.|..|||..|...:..:....:.||:||||
Mouse   497 TDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSK 561

  Fly   591 IKDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDLR-ECAGEHFPSNREVRYSVVSG 654
            ......:| :..||:...|..|..|..|....|:.|.::|...: :|...   ..:::...::|.
Mouse   562 CSSSELMD-HQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNR---GKQDISERLISA 622

  Fly   655 FIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTVEL-- 717
            .:||||..|||:.|.||:|..|..|.:||||||||:|.||:|.|.....:     |||:...:
Mouse   623 SLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGN-----KEEYMAFMND 682

  Fly   718 --------YKKFCTE--------------QHVD-----AVKHFL--EVISTPSHASSSVHPAAAA 753
                    .|:|..|              .::|     :|.|.|  ||:|......:|...|..|
Mouse   683 FLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVA 747

  Fly   754 AT-PLEPVLLKEGLMTKYPTSRKRFGRQFKQRHFRLTTHS----LSYAKSKGKQPICDIPLQEIA 813
            .. ||..||..   :||..|:.....:|.:    |...||    :|.:.|.|.|.||:.|..  :
Mouse   748 KLGPLPRVLAD---ITKSLTNPTPIQQQLR----RFAEHSSSPNVSGSLSSGLQRICEDPTD--S 803

  Fly   814 SVEQLKDKSFKMQNCFKIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFVSGF 878
            .:.:||..|  ..|..........|:||..                  :|..|.|....
Mouse   804 DLHKLKSPS--QDNTDSYFRGKTLLLVQQA------------------SSQSMTYSEKD------ 842

  Fly   879 YSCCGRSDENS-PGCKKVLDKTMDYFQMDLVTALDPALDLQRIHT---------------LIMSN 927
                  ..||| |..:.:                 ..:|||..|.               |..|.
Mouse   843 ------EKENSLPNGRSI-----------------SLMDLQDTHAAQAEHASVMLDVPMRLAGSQ 884

  Fly   928 MSVLE-SLLDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSPQAF----------------AEFKR 975
            :|:.: :.:..|...||..|:..|...||.|.........|.:|                |....
Mouse   885 LSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGSLQPLSFQNPVYHLNNPVPAMPKASADS 949

  Fly   976 TIEKLREKAYAIDRDHRDYK---------QGITRQLKYG---SRQAPIGDDN------------- 1015
            ::|.|...:.....:..|:|         :..|::..:.   ||:..:.|.:
Mouse   950 SLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSSHSEDFSRRHTVPDRHIPLALPRQNSTGQ 1014

  Fly  1016 ----------------------YWHMMRAAGQL-------------NQQHHQQQQHQQQQ----- 1040
                                  :...:|:.|.:             |....:||....::
Mouse  1015 SQIRKLDHSGLGARAKAPPSLPHSASLRSTGSMSVASAALMAEPVQNGSRSRQQSSSSRESPVPK 1079

  Fly  1041 ----QQQQQQQLQQFQPQPVLPQMQNVRAYPYQPAT----SNMNAYCLHNMQYQQ--QRLPFHQQ 1095
                |:||.||:|.                |...||    ....|:.|:|.||::  :....:|.
Mouse  1080 VRAIQRQQTQQVQS----------------PVDSATMSPVERTAAWVLNNGQYEEDVEETEQNQD 1128

  Fly  1096 QQQHHQQLQQQQSQFQP---LRSHQLQRHNNNL 1125
            :.:|.::.:|:.::.:.   :.|.:|:.:...|
Mouse  1129 EAKHAEKYEQEITKLKERLRVSSRRLEEYERRL 1161

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	2/14 (14%)
		C2B_RasA3	280..462	CDD:175977	48/228 (21%)
		RasGAP_GAP1_like	473..740	CDD:213330	83/301 (28%)
		PH_GAP1-like	763..867	CDD:269950	22/107 (21%)
		BTK	862..897	CDD:128417	7/35 (20%)
Rasal2	XP_006496813.1	PH-like	181..364	CDD:473070	34/188 (18%)
		C2_SynGAP_like	306..445	CDD:175980	34/168 (20%)
		RasGAP_DAB2IP	436..766	CDD:213338	94/347 (27%)
		DUF3498	756..1232	CDD:463427	80/480 (17%)