DRSC/TRiP Functional Genomics Resources

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Protein Alignment RasGAP1 and Syngap1

DIOPT Version :10

Sequence 1:NP_001261664.1 Gene:RasGAP1 / 39158 FlyBaseID:FBgn0004390 Length:1181 Species:Drosophila melanogaster
Sequence 2:NP_851606.3 Gene:Syngap1 / 192117 RGDID:621090 Length:1308 Species:Rattus norvegicus


Alignment Length:1255 Identity:261/1255 - (20%)
Similarity:406/1255 - (32%) Gaps:360/1255 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 YCTIA------LDQEEI------------CRTPTIERTLT-PFFGE---EHQFKIPRRFRYLTIY 116
            :|.|:      ||::||            .|...:.||:: |..|.   ||::.:          
  Rat    48 FCIISGNQLLMLDEDEIHPLLIRDRRSESSRNKLLRRTVSVPVEGRPHGEHEYHL---------- 102

  Fly   117 LWDRDMKQDKPIGKIAIKREELHMYNHKDHWFSLRPVDQDSEVQGMVNVEVAFTEAQQTQSLSEG 181
              .|..::..|.|              |.:.....|.......||.::..:. :..::|:|..: 
  Rat   103 --GRSRRKSVPGG--------------KQYSMEAAPAAPFRPSQGFLSRRLK-SSIKRTKSQPK- 149

  Fly   182 IDLGQHTLRHHQNLPHH---SHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTLKTRAAGLF 243
            :|   .|....|.||..   .|.:...:..:||:.     ...|..:.||::.|:.|......:.
  Rat   150 LD---RTSSFRQILPRFRSADHDRARLMQSFKESH-----SHESLLSPSSAAEALELNLDEDSII 206

  Fly   244 GHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKKQGTCDPFVVCTAHY 308
            ..| |.....|.|....|||:.:                 |..||...|::    |.::      
  Rat   207 KPV-HSSILGQEFCFEVTTSSGT-----------------KCFACRSAAER----DKWI------ 243

  Fly   309 SNKHQVTRRTKQRKKTVD--------------PEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLE 359
            .|..:..:..|...:.||              |:  :..|.:|.:| |.....||...:||.   
  Rat   244 ENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPK--KRYYCELCLD-DMLYARTTSKPRSAS--- 302

  Fly   360 SSANKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGE------------VRLPMLNKQEQQA 412
                                            .|.||.||            :||.:....:::.
  Rat   303 --------------------------------GDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKR 335

  Fly   413 VNPSAWYY---------LQPRSMTHSSRSLNATPRSCATPPGTRLSVDSTIG------------- 455
            ....|.|.         |..|..|.     ...|.:..|..|....:.|..|             
  Rat   336 KKDKAGYVGLVTVPVATLAGRHFTE-----QWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKG 395

  Fly   456 ---SLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPITVSAVSILGELVSGKTEVAQPLVRLFT 517
               ::||...|....:.|:..|.:    ..|.|......:.||......|.||.|||..||.:..
  Rat   396 GCPAVRLKARYQTMSILPMELYKE----FAEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQ 456

  Fly   518 HTERIAPIIKALADHEI------SHLTDPTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQ 576
            .|.:....:..:|..|:      .||     |||.|||.:|.::|.|||.|..||...:...:..
  Rat   457 STGKAKDFLSDMAMSEVDRFMEREHL-----IFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRA 516

  Fly   577 IVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDLR-ECAGEH 640
            :...::.||:||.|. ..|::..:..||:...|.....:..|....|..|.::|...| .||.. 
  Rat   517 LYESEENCEVDPIKC-TASSLAEHQANLRMCCELALCKVVNSHCVFPGELKEVFASWRLRCAER- 579

  Fly   641 FPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSS 705
              ...::...::|..:||||..|||:.|.||.|..|..|.|||||||||:|.||:|.|.     |
  Rat   580 --GREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANF-----S 637

  Fly   706 QQTCKEEFTVELYKKFCTEQHVDAVKHFLEVIS---TPSHAS------------SSVHPAAAAAT 755
            :.|.||:| :....:| .|....:::.||..||   |.:::|            |::|   |...
  Rat   638 KFTSKEDF-LGFMNEF-LELEWGSMQQFLYEISNLDTLTNSSSFEGYIDLGRELSTLH---ALLW 697

  Fly   756 PLEPVLLKEGLMTKYPTSRKRFGRQFKQRHFRLTTHSLSYAKSKGKQPICDIPLQEIASVEQLKD 820
            .:.|.|.||.|:...|..|.........|:..:.......::....||:.            |:.
  Rat   698 EVLPQLSKEALLKLGPLPRLLSDISTALRNPNIQRQPSRQSERARSQPMV------------LRG 750

  Fly   821 KSFKMQNCFKIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFVSG-------- 877
            .|.:||....                  |:         |.:||.:|.|......|.        
  Rat   751 PSAEMQGYMM------------------RD---------LNSSIDLQSFMARGLNSSMDMARLPS 788

  Fly   878 -----------------FYSCCGRSDENSPG-CKKVLDKTMDYFQMDLVTALDPALDLQ------ 918
                             ||........:||. |....|.|....:|..|......||||      
  Rat   789 PTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKSVSMLDLQGDGPGG 853

  Fly   919 RIHTLIMSNMSVLESLLDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLREK 983
            |:::..:||::.:..||.  :...||:.....:..|    |..|.:.|..:.     |...:|..
  Rat   854 RLNSSSVSNLAAVGDLLH--SSQASLTAALGLRPAP----AGRLSQGSGSSI-----TAAGMRLS 907

  Fly   984 AYAIDRDHRDYKQGITRQLKYGSRQAPIGDDN-YWHMMRAA---------------GQLNQQHHQ 1032
            ...:..|      |:..|    ..:.|:...| .:||  ||               |..:..||.
  Rat   908 QMGVTTD------GVPAQ----QLRIPLSFQNPLFHM--AADGPGPPAGHGGSSGHGPPSSHHHH 960

  Fly  1033 QQQHQQQQQQQQQQQLQQFQPQPVLPQMQNVRAYPYQPATSNMNAYCLHNMQYQQQRLP----FH 1093
            ...|..:..:........|........:..  ..|..||.|     .||:..|..:..|    |.
  Rat   961 HHHHHHRGGEPPGDTFAPFHGYSKSEDLST--GVPKPPAAS-----ILHSHSYSDEFGPSGTDFT 1018

  Fly  1094 QQQQQHHQQLQQQQSQFQ----PLRSHQLQRHNNNLNNNNCGNGSSSSP-------SSTTSSVVA 1147
            ::|......||...|..|    |.|.........:...:..|.|....|       ..|.|:...
  Rat  1019 RRQLSLQDNLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGGGGQPPPLQRGKSQQLTVSAAQK 1083

  Fly  1148 APPSTTSSSQPAPPIYXRSR 1167
            ..||:.:..|...|.|..:|
  Rat  1084 PRPSSGNLLQSPEPSYGPAR 1103

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RasGAP1NP_001261664.1 C2A_RasA2_RasA3 44..169 CDD:176046 20/116 (17%)
C2B_RasA3 280..462 CDD:175977 37/232 (16%)
RasGAP_GAP1_like 473..740 CDD:213330 87/276 (32%)
PH_GAP1-like 763..867 CDD:269950 16/103 (16%)
BTK 862..897 CDD:128417 10/60 (17%)
Syngap1NP_851606.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 92..113 5/32 (16%)
PH_SynGAP 122..313 CDD:270178 48/266 (18%)
C2_SynGAP_like 252..414 CDD:175980 32/204 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 373..394 2/20 (10%)
RasGAP_DAB2IP 405..728 CDD:213338 102/345 (30%)
DUF3498 718..1295 CDD:463427 81/455 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 725..751 4/37 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 781..809 2/27 (7%)
SH3-binding. /evidence=ECO:0000255 785..815 2/29 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 932..1017 17/93 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1033..1153 15/71 (21%)
Interaction with MPDZ. /evidence=ECO:0000269|PubMed:15312654 1197..1308
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1276..1308
PDZ-binding. /evidence=ECO:0000255 1305..1308
Blue background indicates that the domain is not in the aligned region.

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