Protein Alignment RasGAP1 and gap-2

DIOPT Version :10

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: NP_509596.1
• Gene: gap-2 / 181172
• WormBaseID: WBGene00001516
• Length: 1259
• Species: Caenorhabditis elegans
• Alignment Length: 930
• Identity: 209/930 - (22%)
• Similarity: 332/930 - (35%)
• Gaps: 265/930 - (28%)

  Fly     5 KKRYMFDERDDNNINSPVAVEPSSNNNKMADTREVRIEEQLKVKIG-EAKNLSSRNAANTSCSTQ 68
            :||..|.:.|.:......|.:|||::|            .|:...| .|:.|...:..|.|...:
 Worm    64 EKRVSFKDLDMSGRLPVTAQQPSSSSN------------HLRTGGGLHARKLHRCDTGNMSLLER 116

  Fly    69 GTRDVYCTIALDQEEICRTPTIERTLTP--FFGEEH----QFKIPRRFRYLTIYLWDRDMKQDKP 127
                     .|.:|.:.....|.:...|  .:...|    |.:..|.|:        ||.:.:..
 Worm   117 ---------YLSRENMHTPSPIPQEYQPQANYSSRHVHFAQSQSRRPFQ--------RDQRNENA 164

  Fly   128 IGKIAIKREELHMYNHKDHWFS--LRPVDQDSEVQGMVNVEVAFTEAQQTQSLSEGIDLGQHTLR 190
            ..:..:.|...|:   .||.||  |.|:.:.........:.:...:|...::.|.|..:|..:|
 Worm   165 SIRKRLSRSCDHL---SDHNFSPRLPPIRRKPTKHVPSTLSLVIHDAIHDETNSGGAQVGGESL- 225

  Fly   191 HHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAA--------SSSSAAMTLKTRAAGLFGHVH 247
                             |.:..|..|...|.:..|:        ..||::..|.||.:|...:::
 Worm   226 -----------------DRRGWSGASTGNRTTLTASVHNNLMNGRMSSSSHNLSTRLSGSTQNLN 273

  Fly   248 HPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKKQGTCDPFVVCTAHYSNKH 312
            . |:....|||:...:..||.    .:.||...:..:               ||         :.
 Worm   274 Q-PTNAYGFPIVPPANNPSDS----SASGRIANLLSR---------------PF---------RS 309

  Fly   313 QVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSN-----------------------KS 354
            ...:|||...| ::....||....|| ..||.:|.:..|:                       :|
 Worm   310 NPLKRTKSVSK-MEKSLAEANQHSLH-RVDASNTPSRDSSLYAQPPARRHLSQPAREGSLRACRS 372

  Fly   355 AGSLESSA--------NKGYSIYPVGGADLVEI-----VVSVWH--------------------- 385
            ..||.|||        |:...::|| ...:.|:     :.|.::
 Worm   373 HESLLSSAHSTHMIELNEDNRLHPV-HPSIFEVPNCFRLASTYYSCRTPLERAKWMENLRKTMNP 436

  Fly   386 -----------------DAHG------------------------AMSDKVFLGE-VRLPMLNKQ 408
                             :|.|                        |.:|.||.|| ....||.|.
 Worm   437 RRDQQRRTENSMLIWILEAKGLPAKRKYYCEMTLDKTLYAKTSSKARTDNVFWGENFEFMMLPKI 501

  Fly   409 EQQAVN------------------------------PSAWYYLQPRSMTHSSRSLNATPRSCATP 443
            ::..|:                              ...||      ..::|.|.:.|.|..:..
 Worm   502 DEVCVSLFRESDSKKKKDTLIGYVTIGIDQLSSRSPVERWY------TVNTSHSDSGTSRIASAL 560

  Fly   444 PGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPITVSAVSILGELVSGKTEV 508
            .|...|.:|.  |||:...:.:.|:.||..||:|:..|  ..:..|:......:|.  |..|.::
 Worm   561 GGKSSSQESP--SLRIKARWQSVHILPLRAYDNLLETL--CYNYLPLCEQLEPVLN--VRDKEDL 619

  Fly   509 AQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRPV 573
            |..|||:..........:..|...|:..|.:...:||||||.:|.|:..|:|....||..||...
 Worm   620 ATSLVRVMYKHNLAKEFLCDLIMKEVEKLDNDHLMFRGNTLATKAMESFMKLVADDYLDSTLSDF 684

  Fly   574 LSQIVAEKKPCEIDPSKIKD--RSAVDTNLHNLQDYVERVFEAITKSADRCPKVLCQIFHDLREC 636
            :..::..:..||:||.|:.:  .|:::.|...|..|||..:..|..:..:.||.|..:|..|| |
 Worm   685 IKTVLQCEDSCEVDPQKLGNVSNSSLEKNRALLMRYVEVAWTKILNNVHQLPKNLRDVFSALR-C 748

  Fly   637 AGEHFPSNRE-VRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLV 700
            ..|  ..||| :..:::|..|||||..||||.|.||:|.:|......:|.||||:||:|:|.|.
 Worm   749 RLE--AQNREALADTLISSSIFLRFLCPAILSPSLFNLVSEYPSPTNARNLTLIAKTLQNLANF- 810

  Fly   701 SSRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFLEVISTPSHASSSVHPAAAA---------ATP 756
             |:...:....||..|...:   |.|  .:|.||..||:.|.:....:..|..         ||.
 Worm   811 -SKFGGKEPHMEFMNEFVDR---EWH--RMKDFLLRISSESKSGPEKNADAIVDAGKELSLIATY 869

  Fly   757 LEPV---LLKEGLMTKYPTS 773
            ||..   ||:|....|:|.|
 Worm   870 LEEAWTPLLQEKNGNKHPLS 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	24/133 (18%)
		C2B_RasA3	280..462	CDD:175977	49/310 (16%)
		RasGAP_GAP1_like	473..740	CDD:213330	88/269 (33%)
		PH_GAP1-like	763..867	CDD:269950	4/11 (36%)
		BTK	862..897	CDD:128417
gap-2	NP_509596.1	PH-like	302..494	CDD:473070	33/218 (15%)
		C2_SynGAP_like	436..586	CDD:175980	25/157 (16%)
		RasGAP_DAB2IP	577..905	CDD:213338	103/327 (31%)