Protein Alignment RasGAP1 and rasal3

DIOPT Version :10

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: XP_002935455.2
• Gene: rasal3 / 100488943
• XenbaseID: XB-GENE-6048180
• Length: 1009
• Species: Xenopus tropicalis
• Alignment Length: 1156
• Identity: 228/1156 - (19%)
• Similarity: 393/1156 - (33%)
• Gaps: 353/1156 - (30%)

  Fly   174 QTQSLSEGIDLG---------------------QHTLRHHQNLPHHSHQQRAHLNDYKENSELSN 217
            |..:|.|..|||                     :|||.........|  ::.|.:.:::.|....
 Frog    14 QDSNLPETSDLGSYQWNTAHGQKGGVWGRLQGWRHTLMLQAKETQGS--KKKHRSLFRKKSPSEP 76

  Fly   218 IQRASAAAASSSSAAM----TLKTRAAGLFGHVHHP-PSQTQHFPIINTTSTSSDQLSNWKSHGR 277
            ..|.......|.|..:    .::....|:.|.|..| |......|:.:        :||:.
 Frog    77 PSRGLTKYLHSVSQRLGRKKDIRPSLDGIEGPVPLPVPVSAPEIPVWD--------ISNFS---- 129

  Fly   278 FVGVTIKVPACVDLAK--KQGTCDPFVVCTAHYSNK------HQVTRRTKQRKKTVDPEFDEAMY 334
                  .:..|:.|.|  :||.|        |..::      ..:|.:|.|....|||...|.
 Frog   130 ------LIDGCLLLTKGDEQGAC--------HIRSRTGSCVSKSLTEQTDQTDGVVDPPVPEG-- 178

  Fly   335 FDLHIDADAGS--TNTTG--------SNKSAGSLESSANKGYSIY----PVGGADLVEIV----- 380
               ::|.|..:  .|..|        ..:..||..|...:..|::    .:||.:::::|
 Frog   179 ---NVDPDTKNQFNNVKGLIQKRKKKKTRKKGSASSLQQEERSLHGSRESLGGVEILDLVNEKDV 240

  Fly   381 -VSVWH----------DAHGAMSDKVF--------------LGEVRLPMLNKQEQQAVNPSAWYY 420
             :...|          :...|.|.:.|              |..:..|..:..|:|..:.|.|
 Frog   241 TIKALHSSILGERYCFEIITAESSRCFACSSLQERDRWIENLRRIVQPDKDNFERQESSLSLW-- 303

  Fly   421 LQPRSMTHSSRSLNAT---PRSC------------------------------------------ 440
                  .|.::.|..:   .|||
 Frog   304 ------IHEAKGLPVSGPGSRSCYFCEVQLDGCLYGRTSSKAPEAGVVFWGESFNLRDLSSVQGH 362

  Fly   441 -----------ATPPGT-RLSVDS---------TIG---SLRLNLNYTADHVFPLATYDDLMNLL 481
                       .|..|| .|:::.         .:|   :||:...|....|.|:..|.:....|
 Frog   363 MALHLLQEGKETTGVGTVTLALEGMKDGAEKWVPLGGEMALRVRGRYRKLSVLPVMQYKEFAEYL 427

  Fly   482 ----LE-SVDQRPITVSAVSILGELVSGKTEVAQPLVRLFTHTERIAPIIKALADHEIS-HLTDP 540
                :| |....|| :||        ..|.|:.:.||.:...|.:....:..|...||| |....
 Frog   428 TWRYMELSRAMEPI-LSA--------REKEELGRSLVYVLQSTGKAKEFLVDLGVAEISRHDGQD 483

  Fly   541 TTIFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQ 605
            :.|||.||:|:|.::|.|::.|..||.:||.|.:::|...:...|:||.:..... :..|...|.
 Frog   484 SLIFRENTIVTKAIEEYMKMVGQTYLQETLGPFVNRIYTSEDSHEVDPLRCSPED-LGENRGQLW 547

  Fly   606 DYVERVFEAITKSADRCPKVLCQIFHDLR-ECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPK 669
            ...|...::|.:|.:..|..|.:||...: |.|....|:   :...:||..:||||..||||.|.
 Frog   548 RSCEDAVQSILQSQESFPPDLLEIFSSWQVEVALRGRPA---LGSRLVSASLFLRFLCPAILSPG 609

  Fly   670 LFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTVELYKKFCT---EQHVDAVK 731
            ||:|:.|......:|.|||::|.:|:|.|.  :|..:   |||     |..|..   ||:.|.:.
 Frog   610 LFNLSAEHPQPLAARALTLVAKVLQNLANF--TRFGE---KEE-----YMGFMNGFLEQYGDGMS 664

  Fly   732 HFLEVISTPSHASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRKRFGRQFKQRHFRLTTHSLSYA 796
            .||:.::.|   .|.|.|                  |:|.:|.                 .|:|
 Frog   665 VFLQAVADP---ESEVSP------------------TRYESSA-----------------DLAY- 690

  Fly   797 KSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVHNDRSLIVQTTNCVEEREWFDLLHKICLM 861
                          |:|.:..:      :...|..||.      ||.:.:|...        .::
 Frog   691 --------------ELAVLHSM------LSGIFTGVHQ------QTKDQLEPLP--------TIL 721

  Fly   862 NSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQMDLVTALDPAL----DLQRIHT 922
            .::                     .|..|....:.:.| ||...|.... ||..    ||.::..
 Frog   722 KAL---------------------TEGQPVPASITEHT-DYDNRDEEND-DPVFVTPRDLSKLRP 763

  Fly   923 LI---MSNMSVLESLLDPLTYHQSLSQ--TQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLRE 982
            |:   .|..|:|...|.|.|..:.|.:  .:|......|| |........:...|.|.|.:....
 Frog   764 LVNRSQSMSSLLRERLPPPTRSEFLEKKSRRHVTRTQSVP-AQGRAGRERRRVTEEKGTEDNTLL 827

  Fly   983 KAYAIDRDHRDYKQGITRQLKYGSRQAPI---GDDNYWHMMRAAGQLNQQHHQQQQHQQQ--QQQ 1042
            |...:.|        :........|::.:   .::|..|:.:.|.:...|..|.|:.:.|  :.|
 Frog   828 KIQKLPR--------VRPPSTLPRRKSTVPWCRNENIPHLGQGAEEAVNQEKQLQEMRGQILENQ 884

  Fly  1043 QQQQQLQ------QFQPQPVLPQMQNVR--AYPYQPATSNMNAYCLHNMQ-YQQQRLPFHQQQQQ 1098
            .:|:.|:      ..|.|.:|.|:..|.  ...:|...:...:..|:.:: .::::||......:
 Frog   885 GKQKDLEGQIGILSGQIQEMLGQLAKVEETQRTFQEEMAGQVSLILNRIKALEEKKLPKENSVAE 949

  Fly  1099 HHQQLQQQQSQFQPLRSHQLQRHNNNLNNNNCGNGSSSSPSSTTSSVVAAP 1149
            :..:..:.......:...|    .::.:.:|..||.:....::|||..:.|
 Frog   950 NPAENIEDNHLLAQINEEQ----KDSEDPSNICNGENDPEITSTSSESSLP 996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046
		C2B_RasA3	280..462	CDD:175977	47/302 (16%)
		RasGAP_GAP1_like	473..740	CDD:213330	83/276 (30%)
		PH_GAP1-like	763..867	CDD:269950	13/103 (13%)
		BTK	862..897	CDD:128417	2/34 (6%)
rasal3	XP_002935455.2	PH-like	172..311	CDD:473070	25/151 (17%)
		C2	288..417	CDD:472691	19/136 (14%)
		RasGAP_DAB2IP	408..731	CDD:213338	105/439 (24%)