Protein Alignment RasGAP1 and rasa4

DIOPT Version :10

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: XP_017947086.1
• Gene: rasa4 / 100488193
• XenbaseID: XB-GENE-487134
• Length: 803
• Species: Xenopus tropicalis
• Alignment Length: 994
• Identity: 256/994 - (25%)
• Similarity: 411/994 - (41%)
• Gaps: 248/994 - (24%)

  Fly    45 LKVKIGEAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQFKIPRR 109
            |.::|.|.|||.:::..       |:.|.||.:.:|.|.|.||.|:.:||:||:|||::..:|..
 Frog     7 LFIRIVEGKNLPAKDIT-------GSSDPYCIVKIDDETIIRTATVWKTLSPFWGEEYKVHLPPN 64

  Fly   110 FRYLTIYLWDRD-MKQDKPIGKIAIKREEL--HM--YNHKDHWFSLRPVDQDSEVQGMVNVEVAF 169
            |..::.|:.|.| :.:|..|||:.:.|..|  |.  ||   .|.:|..:|.|.||||.:::::..
 Frog    65 FHSVSFYVMDEDALSRDDVIGKVCLTRNVLAEHPKGYN---GWMNLTEIDPDEEVQGEIHLKIEI 126

  Fly   170 TEAQQTQSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMT 234
            .                     :.|||.
 Frog   127 I---------------------NTNLPR------------------------------------- 133

  Fly   235 LKTRAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKK--QGT 297
             |.|...|...                                            |||:|  .|.
 Frog   134 -KVRCTVLEAR--------------------------------------------DLARKDRNGA 153

  Fly   298 CDPFVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLESSA 362
            .||||  ...|::|.|   .:...||:..|.::||..|||.                    |:..
 Frog   154 SDPFV--RVQYNSKVQ---ESSVVKKSCYPRWNEAFEFDLE--------------------ETIT 193

  Fly   363 NKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQE-QQAVNPSAWYYLQPRSM 426
            .|              :.:.||.  ...:|...|||:|   ::|... |..:....|:.|
 Frog   194 EK--------------LSIEVWD--WDLVSRNDFLGKV---VINLNGLQTTLQEEEWFRL----- 234

  Fly   427 THSSRSLNATPRSCATPPGTRLSVD-STIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQ--R 488
                     :|..|      :.|:| ..:|||:|.:....:.|.|...|..|:.||.:.|..  :
 Frog   235 ---------SPGKC------KASIDEGNLGSLQLQVRLRDETVLPSEYYKPLVQLLCQEVKTSCK 284

  Fly   489 PITVSAVSILGELVSG--KTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVS 551
            ..:|:.:|::.:..|.  :.|||..||:||........::..|...|:....:|.|:||.|:|.|
 Frog   285 EKSVNLISLIDDTASAECRQEVATNLVKLFLGQGIAKELLDLLFRLELDKTNEPNTLFRSNSLAS 349

  Fly   552 KMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHN------------- 603
            |.|:..::::|..|||..:.|.:::|..|||..|:||||::.:.|..:.||.
 Frog   350 KSMESFLKVAGTQYLHSVVGPTINRIFEEKKYVELDPSKVEIKEAGCSGLHRIQTEGELIQQSTQ 414

  Fly   604 -LQDYVERVFEAITKSADRCPKVLCQIFHDLRECAGEHFPSNR--EVRYSVVSGFIFLRFFAPAI 665
             ||.|:..:..:||||...||..:...|..|.:...|.||.|:  .|::..|:.|:.||||:|||
 Frog   415 YLQSYLTDLLLSITKSVKLCPATIRATFRQLYKRVEERFPENKHMNVKFIAVTSFLCLRFFSPAI 479

  Fly   666 LGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTVELYKKFCTEQHVDAV 730
            :.||||.|..:..||:|||||.|::|.||::||:.:..|   ..||.:...|..|.  :|.|..:
 Frog   480 MSPKLFHLREKHADARTSRTLLLLAKAIQNVGNMDAPAS---RAKESWMAPLQPKI--QQGVLQL 539

  Fly   731 KHF-LEVISTPSHASSSVHPAAAAATPLEPVLLKEGLMTKYPTSRKRF--GRQFKQRHFRLTTHS 792
            |.| :::|.........:..|....:|    .:|||.:..|.|..|.:  ...||:....||..:
 Frog   540 KEFIIKLIDIEEKEELDLERALNLQSP----TIKEGQLMIYKTKGKGYLLASSFKKFFITLTPDA 600

  Fly   793 LSYAKSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVHND-----RSLIVQTTNCVEEREWF 852
            ||:|||...:....|||.:|.::|::::|.|...|..:|::.|     .:|.:|..:..|..:|.
 Frog   601 LSFAKSSYSKKSSVIPLSKIRALEKVEEKCFGSSNVMQIIYTDETENLEALYLQCKSVNELNQWL 665

  Fly   853 DLLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQMDLVTALDPALDL 917
            ..|.|:|:.|...:..:||..|....:|||.:.|:...||.|...:.......||   |||.|:.
 Frog   666 SALRKVCVNNPDMLCSYHPGVFKGEKWSCCHQKDKAGAGCDKTRHEVTLQEWNDL---LDPDLEA 727

  Fly   918 QRIHTLIMSNMSVLESLLDPLTYHQSLSQTQHQQHNPLVPLATDLQKHSPQAF------------ 970
            |.|...::....:::.     .|.|...||..:  .||:.....::..:.|.|
 Frog   728 QLIFRHLLGVRELMKE-----KYVQWTEQTDRE--TPLLHSDPQVKDSAAQLFQILHDLEAAHDS 785

  Fly   971 -AEFKRTIEKLREKAYAID 988
             ..|....:|  ||.|.::
 Frog   786 LTVFSNVADK--EKKYLLE 802

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	45/128 (35%)
		C2B_RasA3	280..462	CDD:175977	41/185 (22%)
		RasGAP_GAP1_like	473..740	CDD:213330	96/287 (33%)
		PH_GAP1-like	763..867	CDD:269950	33/110 (30%)
		BTK	862..897	CDD:128417	11/34 (32%)
rasa4	XP_017947086.1	C2A_Rasal1_RasA4	6..126	CDD:176018	45/128 (35%)
		C2	134..256	CDD:472691	44/229 (19%)
		RasGAP_RASA4	264..550	CDD:213343	97/290 (33%)
		PH_CAPRI	542..681	CDD:241523	37/142 (26%)
		BTK	681..710	CDD:459937	10/28 (36%)