Protein Alignment RasGAP1 and rasa3

DIOPT Version :10

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: XP_004911857.1
• Gene: rasa3 / 100144662
• XenbaseID: XB-GENE-920756
• Length: 834
• Species: Xenopus tropicalis
• Alignment Length: 992
• Identity: 351/992 - (35%)
• Similarity: 531/992 - (53%)
• Gaps: 172/992 - (17%)

  Fly    39 VRIEEQLKVKIGEAKNLSSRNAANTSCSTQGTRDVYCTIALDQEEICRTPTIERTLTPFFGEEHQ 103
            :|:.:.:|:||||||||.|....|.      .||.:||:.|||||:.||..:|::|.||:||:..
 Frog     8 IRVFQSVKIKIGEAKNLPSYPGPNK------MRDCFCTVNLDQEEVFRTKIVEKSLCPFYGEDFY 66

  Fly   104 FKIPRRFRYLTIYLWDRDM-KQDKPIGKIAIKREELHMYNHKDHWFSLRPVDQDSEVQGMVNVEV 167
            .:|||.||:|:.|::|||: ::|..:||::|.:|:|..||::|.||.::.||.||||||.|::|:
 Frog    67 CEIPRSFRHLSFYIFDRDVFRRDSIMGKVSILKEDLQQYNNRDTWFQVQHVDADSEVQGKVHLEL 131

  Fly   168 AFTEAQQTQSLSEGIDLGQHTLRHHQNLPHHSHQQRAHLNDYKENSELSNIQRASAAAASSSSAA 232
                     .|||.|                                             :.|..
 Frog   132 ---------RLSEVI---------------------------------------------TDSGV 142

  Fly   233 MTLKTRAAGLFGHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKKQGT 297
            :..|..|..|         :.|..||:|                                   |.
 Frog   143 ICHKLLARVL---------ECQGLPIVN-----------------------------------GQ 163

  Fly   298 CDPFVVCTAHYSNKHQVTRRTKQRKKTVDPEFDEAMYFDLHIDADAGSTNTTGSNKSAGSLESSA 362
            |||:...|....::.: .::||.||||.:|:|||..||::        |.....||
 Frog   164 CDPYATVTLLGPSRSE-AKKTKVRKKTNNPQFDEVFYFEV--------TKPCSYNK--------- 210

  Fly   363 NKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVNPSAWYYLQPRSMT 427
             |.:........|.:||.|.:|:.::....|: ||||:::|:  |..:|:....|||:||||.
 Frog   211 -KSHFEIEEDDVDKLEIRVDLWNASNLKFGDE-FLGELKIPL--KVLRQSSCHGAWYFLQPRD-- 269

  Fly   428 HSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMNLLLESVDQRPITV 492
                            .|..:..|. :||||||:.||.|||||...|..|.:|:|:|.|..|::.
 Frog   270 ----------------NGKSVKPDD-LGSLRLNVVYTEDHVFPSEYYSPLRDLVLKSGDVEPVSA 317

  Fly   493 SAVSILGELVSGKTEVAQPLVRLFTHTERIAPIIKALADHEISHLTDPTTIFRGNTLVSKMMDEA 557
            ||..:|||:...|.|.|.||||||.|..:|.|.|.|:|:.|::...||.||||||:|.||.:||.
 Frog   318 SAAHVLGEVCREKQEAAIPLVRLFLHYGKIVPFISAIANAEVNRTQDPNTIFRGNSLTSKCIDET 382

  Fly   558 MRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYVERVFEAITKSADRC 622
            |:|:|:|||..||:|::.:|....|||||||.|:||....:.|..||::||:|:|:.||||...|
 Frog   383 MKLAGMHYLQVTLKPIIDEICEAHKPCEIDPVKLKDGENFENNKENLKNYVDRIFDVITKSGVSC 447

  Fly   623 PKVLCQIFHDLRECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLT 687
            |.|:|.||..|||.|.:.|..:.:||::.||.||||||||||||.|.||.|:....|.|||||||
 Frog   448 PTVMCDIFFSLRESAAKRFQGDPDVRFTAVSSFIFLRFFAPAILSPNLFQLSPHHPDPQTSRTLT 512

  Fly   688 LISKTIQSLGNLVSSRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFLEVISTPSHASSSVHPAAA 752
            |||||||:||:|  |:|...:.||.:....|:.|..:::.||||:||::||:.....   |....
 Frog   513 LISKTIQTLGSL--SKSKSASFKENYMAAFYENFNEQKYADAVKNFLDLISSSGRRD---HKRIE 572

  Fly   753 AATPLEPVLLKEGLMTKYPTSRKRFG-RQFKQRHFRLTTHSLSYAKSK-GKQPICDIPLQEIASV 815
                 :|:|||||.|.|....||||| :.||:|.||||.|..:|.||| |..|:|.||::.|.:|
 Frog   573 -----QPILLKEGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYQKSKAGDHPLCSIPIENILAV 632

  Fly   816 EQLKDKSFKMQNCFKIVHNDRSLIVQTTNCVEEREWFDLLHKICLMNSIRMQYFHPSAFVSGFYS 880
            |:|:::||||:|.|:::...|:|.:|..||||.::|.|:|.|:...|..|:..:||||:::..:.
 Frog   633 EKLEEESFKMKNMFQVIQPVRTLYIQANNCVEAKDWIDILTKVSQCNKKRLTVYHPSAYLNAHWL 697

  Fly   881 CCGRSDENSPGCKKVLDKTMDYFQMDLVTALDPALDLQRIHTLIMSNMSVLESLLDPLTYHQSLS 945
            ||..:.||:|||...........|:|    :|...:.:||::|..:.:..||.:.:.........
 Frog   698 CCKATSENAPGCTPCTGGLPANIQLD----IDGDRETERIYSLFNTYICKLEKMQEACGSKSVYD 758

  Fly   946 QTQHQQHNPLVPLATDLQKHSPQAFAEFKRTIEKLREKAYAIDRDHRDYKQGITRQLKYGSRQAP 1010
            ..:.::::..:       ...|:   |..:|:.::.:....::::|..||:...::.||||::.|
 Frog   759 GPEQEEYSTFL-------IDEPR---ETYKTLYQIIDGVKTLEQEHAQYKRDKFKKTKYGSQEHP 813

  Fly  1011 IGDDNYWHMMRAAGQLN 1027
            |||.::...:|...:::
 Frog   814 IGDKSFQSYIRQQSEVS 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	59/125 (47%)
		C2B_RasA3	280..462	CDD:175977	49/181 (27%)
		RasGAP_GAP1_like	473..740	CDD:213330	135/266 (51%)
		PH_GAP1-like	763..867	CDD:269950	50/105 (48%)
		BTK	862..897	CDD:128417	13/34 (38%)
rasa3	XP_004911857.1	C2A_RasA2_RasA3	13..133	CDD:176046	59/134 (44%)
		C2B_RasA3	146..287	CDD:175977	56/225 (25%)
		RasGAP_RASA3	296..564	CDD:213336	135/269 (50%)
		PH_GAP1_mammal-like	561..686	CDD:241522	55/132 (42%)
		BTK	679..714	CDD:128417	13/34 (38%)