Protein Alignment RasGAP1 and syngap1

DIOPT Version :10

• Sequence 1: NP_001261664.1
• Gene: RasGAP1 / 39158
• FlyBaseID: FBgn0004390
• Length: 1181
• Species: Drosophila melanogaster
• Sequence 2: XP_031748229.1
• Gene: syngap1 / 100038210
• XenbaseID: XB-GENE-487270
• Length: 1222
• Species: Xenopus tropicalis
• Alignment Length: 1293
• Identity: 254/1293 - (19%)
• Similarity: 431/1293 - (33%)
• Gaps: 382/1293 - (29%)

  Fly    74 YCTIA------LDQEEI------------CRTPTIERTLT-PFFG---EEHQFKIPRRFRYLTIY 116
            ||.::      ||:||:            .||..:.||:: |..|   :||.:.:.
 Frog    34 YCVLSGNQLLMLDEEEVHPLLIRERRTDPTRTKFLRRTVSVPVEGKQPDEHDYHLA--------- 89

  Fly   117 LWDRDMKQDKPIGKIAIKREELHMYNHKDHWFSLRPVDQDSEVQGMVNVEVAFTEAQQTQSLSEG 181
               |..::..|.|              |.......|.......||.::..:. :..::|:|..:
 Frog    90 ---RSRRKSVPGG--------------KQPSMDAPPTAPFRPSQGFLSRRLK-SSIKRTKSQPK- 135

  Fly   182 IDLGQHTLRHHQNLPHH---SHQQRAHLNDYKENSELSNIQRASAAAASSSSAAMTLKTRAAGLF 243
            :|   .|....|.||..   .|.:...:..:||:.     ...|..:.||::.|:.|......:.
 Frog   136 LD---RTSSFRQILPRFRSADHDRARLMQAFKESH-----SHESLLSPSSAAEALDLNLDEDSVV 192

  Fly   244 GHVHHPPSQTQHFPIINTTSTSSDQLSNWKSHGRFVGVTIKVPACVDLAKKQGTCDPFVVCTAHY 308
            ..| |.....|.|....|||:.:                 |..||...|::    |.::
 Frog   193 KPV-HSSILGQEFCFEVTTSSGT-----------------KCFACRSAAER----DKWI------ 229

  Fly   309 SNKHQVTRRTKQRKKTVD--------------PEFDEAMYFDLHIDADAGSTNTT---------- 349
            .|..:..:..|...:.||              |:  :..|.:|.:| |.....||
 Frog   230 ENLQRAVKPNKDNSRRVDNVLKLWIIEARDLPPK--KRYYCELCLD-DILYARTTSKPRNDTVFW 291

  Fly   350 GSNKSAGSLESSANKGYSIYPVGGADLVEIVVSVWHDAHGAMSDKVFLGEVRLPMLNKQEQQAVN 414
            |.:....:|.:..|....:|    .|.         |.........::|.|.:|:.:...:..|
 Frog   292 GEHFEFNNLPAVRNLRLHLY----KDT---------DKKRRKEKSNYVGMVNVPIASISGRHFV- 342

  Fly   415 PSAWYYLQPRSMTHSSRSLNATPRSCATPPGTRLSVDSTIGSLRLNLNYTADHVFPLATYDDLMN 479
             ..||   |.|...|.:..::.|                  |:||...|....:.|:..|.:...
 Frog   343 -EQWY---PVSQPTSYKGKSSCP------------------SIRLKSRYQTMSILPMELYKEFAE 385

  Fly   480 LLLESVDQRPITVSAVSILGELVSGKTEVAQPLVRLFTHTERIAPIIKALADHEISHLTD-PTTI 543
            .:..  :.|.:......:|.  |..|.|||..||.:...|.:....:..:|..|:....| ...|
 Frog   386 YVTN--NYRMLCAVLEPVLS--VKSKEEVACALVHILQSTGKAKDFLSDMAMTEVDRFLDREHLI 446

  Fly   544 FRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKDRSAVDTNLHNLQDYV 608
            .|.|||.:|.::|.::|.|..||.:.:...:..:...::.||:||.:... ||:..:..||:...
 Frog   447 LRENTLATKAIEEYLKLIGQRYLKEAIGEFIRALYESEEDCEVDPMRCPP-SALPDHQANLRMCC 510

  Fly   609 ERVFEAITKSADRCPKVLCQIFHDLR-ECAGEHFPSNREVRYSVVSGFIFLRFFAPAILGPKLFD 672
            |.....:..|....|:.|.::|...| .||..   ...::...::|..:||||..|||:.|.||.
 Frog   511 ELALCKVFNSHCVFPRELKEVFASWRMRCAER---GREDIADRLISASLFLRFLCPAIMSPSLFS 572

  Fly   673 LTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCKEEFTVELYKKFCTEQHVDAVKHFLEVI 737
            |..|..|.|||||||||:|.||:|.|.....||    |||: :....:| .|..:..:::||..|
 Frog   573 LMQEYPDEQTSRTLTLIAKVIQNLANFNYKFSS----KEEY-MSFMNEF-LETELANMQNFLYEI 631

  Fly   738 STPSHASSSVH------------PAAAAATPLEPVLLKEGLMTKYPTSR--KRFGRQFKQRHF-R 787
            |.....::|::            ...|....:.|.|.|:.|:...|..|  .......:..|. |
 Frog   632 SNLDSLTNSINFEGYIDLGRELSTLHALLWEVIPQLSKDALIKLGPLPRLLNDISLALRNPHIQR 696

  Fly   788 LTTHSLSYAKSKGKQPICDIPLQEIASVEQLKDKSFKMQNCFKIVHNDRSLIVQT-----TNCVE 847
            ..:|.......|   |:.            |:..|.::|:  .:|.:..|.|..|     |....
 Frog   697 QPSHQERLPPPK---PVI------------LRGPSAELQS--YLVRDLNSSIDMTRLPSPTKDKP 744

  Fly   848 EREWFDLLHKICLMNSIRMQYFHPSAFVSGFYSCCGRSDENSPGCKKVLDKTMDYFQMDLV-TAL 911
            .::.|.:..:             |....|..| |...||...|. :|:|........|||. :.:
 Frog   745 SKDMFFVSRR-------------PLTRSSPAY-CTSSSDITEPD-QKMLSVNKSVSMMDLQDSRM 794

  Fly   912 DPALDLQRIHTLIMSNMSVLESLLDP-----------LTYHQSLSQ-------TQHQQ------- 951
            :...:||.:..|:.|:.:.:...|.|           :.....|||       ...||
 Frog   795 NSVTNLQAVGDLLNSSQASISGGLRPGGRLSQGSGSSIAAGLRLSQMGVTTDGLSAQQLRIPLSF 859

  Fly   952 HNPLVPLATD--------LQKHSP----QAFAEFKRTIEKLREKAYAIDRD---------HRDYK 995
            .|||..:|.|        ...|.|    .|||.|         ..|:...|         ...|.
 Frog   860 QNPLFHMAPDGPGGPPSHPAPHRPDPGADAFAPF---------HGYSKSEDLSSGKHMLHSHSYS 915

  Fly   996 QGITRQ-LKYGSRQAPIGDDNYWHM---------------------------------------- 1019
            ...:|| .::..||..: .||..||
 Frog   916 DEFSRQGSEFSKRQLSL-QDNLQHMLSPPQITIGPGVPRRQDSQPPPLQRGKSQQLTVQAAHKPR 979

  Fly  1020 ------------MRAAGQLNQQHHQQ----------QQHQQQQQ--------------------- 1041
                        |..|.::.||..::          :||...|.
 Frog   980 PSSGNLLQSPEPMYGAARIRQQSVEKDAGGLKPSITKQHSHAQATLNPVTPASERTVAWVSNMPH 1044

  Fly  1042 ----------QQQQQQLQQFQPQPVLPQMQNVRAYPYQPATSNMNAYCLHNMQYQQQRLPFHQQQ 1096
                      ::::.:|:::.......:::.|:.|. :...|......:.|.:.::.......|:
 Frog  1045 LSADIESAHIEREEYKLKEYSKSMDESRLERVKEYE-EEIYSLKERLLMSNRKLEEYERRLLTQE 1108

  Fly  1097 QQHHQQLQQQQSQF----QPLRSHQLQRHN------NNLNNNNCGNGSSSSPSSTTSS 1144
            :|.::.:||.||:.    :.||..|:::..      |.|...:.|.|.....|.|.::
 Frog  1109 EQTNKMMQQYQSRLDQSEKRLRQQQVEKDTQIKSILNRLEMVDAGGGGDQEGSLTRTN 1166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RasGAP1	NP_001261664.1	C2A_RasA2_RasA3	44..169	CDD:176046	21/116 (18%)
		C2B_RasA3	280..462	CDD:175977	35/205 (17%)
		RasGAP_GAP1_like	473..740	CDD:213330	80/268 (30%)
		PH_GAP1-like	763..867	CDD:269950	18/111 (16%)
		BTK	862..897	CDD:128417	8/34 (24%)
syngap1	XP_031748229.1	PH_SynGAP	108..296	CDD:270178	42/228 (18%)
		C2_SynGAP_like	238..377	CDD:175980	30/177 (17%)
		RasGAP_DAB2IP	368..692	CDD:213338	90/337 (27%)
		DUF3498	682..1197	CDD:463427	86/528 (16%)