Protein Alignment path and unc-47

DIOPT Version :10

• Sequence 1: NP_648327.1
• Gene: path / 39106
• FlyBaseID: FBgn0036007
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_499255.1
• Gene: unc-47 / 176431
• WormBaseID: WBGene00006783
• Length: 486
• Species: Caenorhabditis elegans
• Alignment Length: 511
• Identity: 110/511 - (21%)
• Similarity: 206/511 - (40%)
• Gaps: 115/511 - (22%)

  Fly     6 DSGSKHAPQEMEQFLPGEGKVMYKIQPRKSD---TEQALAGNDFDPFALRDNPH-----PTTDNE 62
            :|||...|.  ::..|.:..|:.: ||:|.|   .|:|           :|:.|     |.:..:
 Worm    43 ESGSNPPPH--DRLEPIQESVVSE-QPQKDDINKQEEA-----------KDDGHGEASEPISALQ 93

  Fly    63 TLTHLLKASLGTGILGMPFAFMCSGLIMGIFSTIFTAFICTHCSYVLVKCGHKLYYRTRRTKMTF 127
            ...::..|..|..|:|:|.|....|. ..|.:.:..|::|.....:|::|   ||....:.:.|:
 Worm    94 AAWNVTNAIQGMFIVGLPIAVKVGGW-WSIGAMVGVAYVCYWTGVLLIEC---LYENGVKKRKTY 154

  Fly   128 AEIAEAAFQKGP---KWCRGFAPVAKFSILFGLFLTYFGTCSVYTVIVASNFEQLI-----SYWT 184
            .|||:  |.| |   ||           :|.........||.:|.|:.|...:...     :.|.
 Worm   155 REIAD--FYK-PGFGKW-----------VLAAQLTELLSTCIIYLVLAADLLQSCFPSVDKAGWM 205

  Fly   185 GTAVSLRMLICIMLVPLILIAWVPNLKYLAPVS-MVANVFMGLGL----------GITFYYLVQD 238
             ...|..:|.|..|..|.:::   .|.:...:| ::.|:.|.|..          .|||
 Worm   206 -MITSASLLTCSFLDDLQIVS---RLSFFNAISHLIVNLIMVLYCLSFVSQWSFSTITF------ 260

  Fly   239 LPPVEERESVVWSTLPQFFSITIFAMEAIGVVMPLENNMKTPQSFLGICGVLSQGMSGVTLIYML 303
                    |:..:|||....:.:|...:...:..||.|||.|..|   ..:|........:..::
 Worm   261 --------SLNINTLPTIVGMVVFGYTSHIFLPNLEGNMKNPAQF---NVMLKWSHIAAAVFKVV 314

  Fly   304 LGFLGYLRYGSATGESITLNLPIEEWPAQTVKVLISLAV----YCTFGLQFFVCLEIIWDGIKEK 364
            .|.||:|.:|..|.|.|:.:|     |.|:.|:|::|.:    ..::.|.|:..::::.:.:...
 Worm   315 FGMLGFLTFGELTQEEISNSL-----PNQSFKILVNLILVVKALLSYPLPFYAAVQLLKNNLFLG 374

  Fly   365 CKKRPTLVNY-----------VLRTVLVTAAVVLAVAVPTIGPFMGLIGAFCFSILGLIFPVVIE 418
            ..:.|....|           .||.:||...:.:|::||.:...|||:|....::|..|:|.:..
 Worm   375 YPQTPFTSCYSPDKSLREWAVTLRIILVLFTLFVALSVPYLVELMGLVGNITGTMLSFIWPALFH 439

  Fly   419 LIV------HWESGFGKYNWILWKNAIITLCGIGALVFGTQAAIKDIVKAYSNNEN 468
            |.:      ::|..|.:.         |.:.|....:.|...:..::::|.::.::
 Worm   440 LYIKEKTLNNFEKRFDQG---------IIIMGCSVCISGVYFSSMELLRAINSADS 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
path	NP_648327.1	SLC5-6-like_sbd	56..456	CDD:444915	96/444 (22%)
unc-47	NP_499255.1	Aa_trans	88..475	CDD:279788	95/439 (22%)