Protein Alignment CG3448 and XRCC4

DIOPT Version :10

• Sequence 1: NP_648316.1
• Gene: CG3448 / 39094
• FlyBaseID: FBgn0035996
• Length: 235
• Species: Drosophila melanogaster
• Sequence 2: NP_071801.1
• Gene: XRCC4 / 7518
• HGNCID: 12831
• Length: 336
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 55/266 - (20%)
• Similarity: 97/266 - (36%)
• Gaps: 71/266 - (26%)

  Fly     6 VKLLQRSQLSHSQIDVKPFIYVRSKWMDDDVE--FDILTTSDNQNYRSIVKYDEFRSGASELEQA 68
            :.|:....::|         :::..| :..:|  |.|..|..:..:...|...|....|.::...
Human     8 IHLVSEPSITH---------FLQVSW-EKTLESGFVITLTDGHSAWTGTVSESEISQEADDMAME 62

  Fly    69 YDAFFAECKSAVTTHMGLQG------------FDYEISMEDVEKPAFKVYKCEGYETLYLDVPLR 121
            ...:..|.:.|:.:..|...            |.:|.:::||.      ::...:.       |.
Human    63 KGKYVGELRKALLSGAGPADVYTFNFSKESCYFFFEKNLKDVS------FRLGSFN-------LE 114

  Fly   122 KVSN---------CYQMLDAAIEAGQQKPQAAPATE------SDAQTTASLAEYEKYVRDSKLKE 171
            ||.|         || .||...|...:........|      :|.|     ..:||.|...:..|
Human   115 KVENPAEVIRELICY-CLDTIAENQAKNEHLQKENERLLRDWNDVQ-----GRFEKCVSAKEALE 173

  Fly   172 EELLKKFLLLLNSKKAHIRDLESQL----EKRSGKVSRAKNNQRIFSD---DEDDAYGAATQVMN 229
            .:|.|:|:|:||.||..||.|.::|    ::|. |..:.:....|.|:   |.|..|..:|
Human   174 TDLYKRFILVLNEKKTKIRSLHNKLLNAAQERE-KDIKQEGETAICSEMTADRDPVYDEST---- 233

  Fly   230 IDNDSD 235
             |.:|:
Human   234 -DEESE 238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3448	NP_648316.1	None
XRCC4	NP_071801.1	Interaction with IFFO1. /evidence=ECO:0000269|PubMed:31548606	1..213		47/234 (20%)
		XRCC4	2..334	CDD:369011	55/266 (21%)
		Interaction with LIG4. /evidence=ECO:0000269|PubMed:11702069	180..213		12/33 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..249		8/32 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..336
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:25934149, ECO:0000269|PubMed:33725486	270..275